An interventional study of Visual assessment and ICG visuals assessment in Colorectal Disease Requiring Elective Laparoscopic Resection and Colorectal Anastomotic Leak, sponsored by Alexandria University. Completed at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-17.
Sponsored by Alexandria University · Not applicable, Interventional, and Health services research
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Among 13 studies in Anastomotic Leak with a site in Egypt — 4 open to participants now, 4 under way, none of them phase 3. Anastomotic Leak · Egypt.
Among the 13 studies in Anastomotic Leak with a site in Egypt, this one is the 2nd largest by enrollment of the 10 interventional ones that give a count, is one of 4 that started in 2025, is one of 7 with no phase, and was the 13th registered.
240 studies on the registry are indexed under Anastomotic Leak; 72 are open to participants now.
Browse Anastomotic Leak studies →4 of the 13 studies in Anastomotic Leak with a site in Egypt are open now. Recruiting first, the newest first:
Minia University · Sites in Egypt
Ages 18–75
Minia University · Sites in Egypt
Ages 18–75
Minia University · Sites in Egypt
Ages 18–80
General Committee of Teaching Hospitals and Institutes, Egypt · Sites in Egypt
Healthy volunteers
A study can be open while its sites in Egypt have not opened yet or have stopped. Only those recruiting at a site in Egypt →
Of the 45 Anastomotic Leak studies recruiting now, 23 (51%) set no upper age limit and 11 (24%) stop at 75 or younger; 1 takes children under 18; 1 takes healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
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13 studies; the count open now beside each. This study's row is marked.
First in 2015; this study’s year is marked. 4 started in 2025.
This study's enrollment of 120 is below the median of 140 across 128 interventional studies indexed under Anastomotic Leak.
Median enrollment 85 across the 10 interventional studies, 430 across the 3 observational. Of the 8 that completed or were terminated, 0 (0%) have results posted.
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1 of 13 have an industry lead sponsor. The 8 most frequent:
Alexandria University is the lead sponsor of 606 studies on the registry; 141 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Alexandria University has 3 studies filed under Anastomotic Leak — fewer than ten, so there is no comparison to draw.
2 of the studies in Anastomotic Leak with a site in Egypt that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07132541Minia UniversitySaleh's Technique for Pancreaticojejunostomy (Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate) | 2026-11-25 |
| NCT07144683Minia UniversityAnastomotic Leakage After Colorectal Surgery. | 2027-03-25 |
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Among the 13 studies in Anastomotic Leak with a site in Egypt, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This prospective randomized controlled trial evaluates whether intraoperative indocyanine green (ICG) fluorescence angiography reduces clinically significant anastomotic leakage after elective laparoscopic colorectal resection with primary anastomosis. A total of 120 adults were allocated in a 1:1 ratio to ICG-guided perfusion assessment or standard visual perfusion assessment, with 60 participants in each group. In the ICG arm, ICG 0.2 mg/kg was administered intravenously after bowel mobilization and before transection, and near-infrared imaging guided selection of a well-perfused transection margin. Participants were followed for 90 days after surgery for grade B or C anastomotic leakage.
Adequate perfusion is essential for colorectal anastomotic healing. Standard intraoperative assessment relies on bowel color, mesenteric pulsation, and bleeding from the cut edge. ICG fluorescence angiography provides real-time near-infrared visualization of bowel perfusion and may identify inadequately perfused segments before anastomosis.
Eligible participants undergoing elective laparoscopic colorectal resection with planned primary anastomosis were randomized using closed-envelope allocation. In the experimental arm, fluorescence was evaluated using a standardized ordinal score: 0, no fluorescence within 60 seconds; 1, delayed or patchy fluorescence at 60 seconds; 2, reduced but homogeneous fluorescence within 30-60 seconds; and 3, rapid homogeneous fluorescence within 30 seconds. Time to fluorescence was recorded at a defined region of interest, and transection was performed at an area showing grade 3 perfusion. In the comparator arm, transection and anastomosis proceeded using standard visual assessment without ICG.
Postoperative evaluation included clinical surveillance. Contrast-enhanced computed tomography of the abdomen and pelvis was obtained when clinically indicated. Clinically significant anastomotic leakage was defined as grade B or C leakage within 90 days and confirmed by clinical findings, contrast imaging, or reoperation.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
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You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Assess the blood supply using icg
Other: Visual assessment
Immediate visual assessment for colon blood supply
Diagnostic Test: ICG visuals assessment
Visual assessment
Injection of ICG and visually asses vascularity
Incidence of clinically significant anastomotic leakage
Incidence of clinically significant anastomotic leakage, defined as Grade B or Grade C leak, .
Time frame: 90 days after surgery
Change in the planned bowel transection margin after ICG assessment
Change in the planned bowel transection margin after ICG assessment
Time frame: One hour intraoperative
Operative time
Operative time taken from skin to skin
Time frame: Hours in the operative theater
ICG-related adverse reactions, such as hypotension or allergic reaction
ICG-related adverse reactions, such as hypotension or allergic reaction
Time frame: 4 Hours intraoperative
Ran from Aug 2025 to primary completion in Sep 2026, 13 months.
Of 58 non-industry interventional studies with no phase under Anastomotic Leak, half reached primary completion within 32 months of starting (the median), counting those still running; a quarter within 19 and three quarters within 42. This study's 13 months is below that.
Counting every sponsor, half of 65 studies reached it within 32 months; a quarter within 19 and three quarters within 42.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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