Anastomotic Leak clinical trials
The registry lists 240 studies for Anastomotic Leak across more than 10 countries. 72 are recruiting or about to start. 115 of them are mainly about Anastomotic Leak (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Status
Who runs them
Amsterdam UMC, location VUmc (5) · Nanchong Central Hospital (5) · FluidAI Medical (4) · Odense University Hospital (4) · Radboud University Medical Center (3) · Southwest Hospital, China (3) · Charite University, Berlin, Germany (3) · Minia University (3)
What is being tested here
Drugs under test in Anastomotic Leak studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Enbucrilate | 2 | 0 | 2 |
| Indocyanine Green | 1 | 0 | 2 |
| Inulin | 1 | 0 | 1 |
| Somatostatin | 1 | 0 | 1 |
| Bioseal | 0 | 1 | 2 |
| Fibrin Tissue Adhesive | 0 | 0 | 2 |
| Albumins human | 0 | 0 | 1 |
| Nystatin | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Endoluminal Vacuum Therapy to Prevent Anastomotic Leakage After Esophagectomy Due to Esophageal Cancer · Aesculap AG
- Nov 2026Saleh's Technique for Pancreaticojejunostomy (Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate) · Minia University
- Dec 2026Indocyanine Green-guided Omental Shield Anastomosis for Cervical Esophagogastric Anastomosis in Minimally Invasive McKeown Esophagectomy · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
- Jan 2027Intracorporeal Versus Extracorporeal Anastomotic After Laparoscopic Right Colectomy · Beijing Friendship Hospital
- Jan 2027OBSiDiAN in a Stapled Circular Esophagogastric Anastomosis After Ivor Lewis Esophagectomy · University Hospital, Ghent
- Mar 2027Anastomotic Leakage After Colorectal Surgery. · Minia University
- Apr 2027Endoscopic COlorectal Mucosal Evaluation of Oxygen Tension · Vanderbilt University Medical Center
- Apr 2027Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections · Medtronic - MITG
- May 2027Betacyanin for Early Diagnosis and Recovery of Anastomotic Leakage After Rectal Cancer Surgery: A Single-Center, Prospective, Controlled Trial · Southwest Hospital, China
- Jun 2027REsults of LOw Anterior Resections With or Without Preventive Stoma in Nonemergency Department · ANO Scientific and Practical Club for the Development of Modern Medical Technologies
Who these studies take
Of the 45 Anastomotic Leak studies recruiting now, 23 (51%) set no upper age limit and 11 (24%) stop at 75 or younger. 1 (2%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (2%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 43 (96%) | 43 (96%) |
| 30 | 44 (98%) | 44 (98%) |
| 40 | 45 (100%) | 45 (100%) |
| 50 | 45 (100%) | 45 (100%) |
| 65 | 45 (100%) | 45 (100%) |
| 75 | 42 (93%) | 42 (93%) |
| 85 | 27 (60%) | 27 (60%) |
Across all 240 studies, recruiting or not: 13% stop at 75 or younger and 3% at 65; 13% take children; 2% are for women only and 0% for men only; 5% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Anastomotic Leak studies take
Of 65 interventional studies with no phase under Anastomotic Leak, half reached primary completion within 32 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 32 mo19–42 · 65 studies | — | 32 mo19–42 · 58 studies |
| Observational | 33 mo23–98 · 52 studies | — | 33 mo22–73 · 50 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered5
- Prospective, Multicenter, Randomized Controlled Phase III Trial of Biological Mesh for Alimentary Tract Reconstruction in Digestive SurgeryNov 6, 2026NCT07921732
- Intra-Operative Infrared Thermography for Bowel ResectionOct 30, 2026NCT07906704
- FLuorescent Angiography in REduction of Anastomotic Leak in Rectal Cancer SurgeryOct 27, 2026NCT07899125
- Surgical Intuition in Anastomotic Leakage After Colorectal SurgeryOct 22, 2026NCT07888478
- Perioperative Biomarkers in Colorectal and Gastric Cancer SurgeryOct 19, 2026NCT07881133
Studies
Recruiting first, then most recently updated. Showing 50 of 240. Browse all 240 → or search them.
- Anastomotic Leakage After Colorectal Surgery.RecruitingNCT071446831 country
- Prospective, Multicenter, Randomized Controlled Phase III Trial of Biological Mesh for Alimentary Tract Reconstruction in Digestive SurgeryRecruitingNCT07921732Not applicable1 country
- Endo-SPONGE for Treatment of Anastomotic or Hartmann's Stump Leakages in Lower Pelvic AreaRecruitingNCT07035431Not applicable1 country
- Pre-emptive Endoscopic Vacuum Therapy Reduces the Incidence of Anastomotic Leakage After Colorectal Cancer SurgeryRecruitingNCT07208786Not applicable1 country
- FLuorescent Angiography in REduction of Anastomotic Leak in Rectal Cancer SurgeryNot yet recruitingNCT07899125Not applicable1 country
- Surgical Intuition in Anastomotic Leakage After Colorectal SurgeryRecruitingNCT078884781 country
- Perioperative Biomarkers in Colorectal and Gastric Cancer SurgeryRecruitingNCT07881133Not applicable1 country
- Study of Eso-SPONGE for Treating Leaks After Upper Gastrointestinal SurgeryNot yet recruitingNCT07711093Not applicable1 country
- OBSiDiAN in a Stapled Circular Esophagogastric Anastomosis After Ivor Lewis EsophagectomyRecruitingNCT05713955Phase 21 country
- Saleh's Technique for Pancreaticojejunostomy (Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate)RecruitingNCT07132541Phase 11 country
- Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal ResectionsRecruitingNCT07351071Not applicable1 country
- PARLAR-02 Trial:Modified Transanal Drainage Tube Use for Preventing Anastomotic LeakageRecruitingNCT07036588Not applicable1 country
- Safety and Effectiveness Evaluation of the COLO-BT as an Alternative Treatment to the IleostomyRecruitingNCT05826743Not applicable1 country
- Anastomotic Leakage Prevention by Endovascular Stenting of the Superior Mesenteric ArteryRecruitingNCT07486570Not applicable1 country
- Betacyanin for Early Diagnosis and Recovery of Anastomotic Leakage After Rectal Cancer Surgery: A Single-Center, Prospective, Controlled TrialNot yet recruitingNCT07726966Not applicable1 country
- COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine GreenNot yet recruitingNCT07720505
- The Value of Early Postoperative Colonoscopy in The Early Diagnosis of Anastomotic Leakage After Surgery for Low Colorectal CancerRecruitingNCT07588386Not applicable1 country
- Endoscopic COlorectal Mucosal Evaluation of Oxygen TensionRecruitingNCT074679801 country
- Leakage Rate of Ileo-COlic Sutured Anastomosis After Right HemicolectomyRecruitingNCT071329701 country
- VACStent Use for the Treatment of Anastomotic Leakage Following coloREctal SurgeryNot yet recruitingNCT07631702Not applicable1 country
- Somatostatin Plus Clear Liquid Diet Versus Diverting Stoma in Patients With Rectal Cancer Undergoing Ultra-Low Anterior ResectionRecruitingNCT07605611Not applicable1 country
- REsults of LOw Anterior Resections With or Without Preventive Stoma in Nonemergency DepartmentRecruitingNCT07463261Not applicable1 country
- The Transit Bipartition With the Use of a Metallic Anastomosis Clip and Circular Fundocorporeal GastroplicationRecruitingNCT07495020Not applicable1 country
- Luso-Cor Stent Compared to Other Endoscopic Techniques for Management of Fistulas and Anastomotic Dehiscences(ES-LCCE-UDFM)Enrolling by invitationNCT068624791 country
- Efficacy and Safety of Colorectal Anastomotic Leak TestingRecruitingNCT06865638Not applicable1 country
- Stapler Reinforcement Patches Compared to Standard Staplers in GastrojejunostomyRecruitingNCT06464978Not applicable1 country
- MIMICC Study in Patients With Colorectal CancerRecruitingNCT07494201Not applicable1 country
- CRP Point-of-care Testing Trajectory, a Predictive Factor for Anastomotic Leak in Elective Colorectal SurgeryRecruitingNCT07464600Not applicable1 country
- Registry Study of People Who Are Having an Esophagectomy and Are at High Risk of Anastomotic LeakRecruitingNCT074492081 country
- Single-Stapled Technique for Colorectal AnastomosisRecruitingNCT074173581 country
- Indocyanine Green-guided Omental Shield Anastomosis for Cervical Esophagogastric Anastomosis in Minimally Invasive McKeown EsophagectomyNot yet recruitingNCT07376876Phase 21 country
- The SMART Trial: Modified Single-Stapled Anastomosis in Laparoscopic or Robotic Low Anterior Resection for Rectal CancerEnrolling by invitationNCT07376980Not applicable1 country
- Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal CancerRecruitingNCT05943444Not applicable1 country
- Surgical Outcomes in Splenic Flexure Cancers: A Multicenter Comparison of Segmental vs. Extended Hemicolectomy (SPARROW Study)Enrolling by invitationNCT072895681 country
- Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylateRecruitingNCT07230509Phase 21 country
- Endoscopic Metabolic and Bariatric TherapiesEnrolling by invitationNCT057259671 country
- PPG vs. ICG in Gastrointestinal ResectionsRecruitingNCT06222645Not applicable2 countries
- Study on the Correlation Between Serum and Fecal Sialic Acid Levels and Tumor Characteristics as Well as Postoperative Anastomotic Leakage in Patients With Colorectal TumorsNot yet recruitingNCT071896631 country
- Low Powered Colorectal Anastomosis After Rectal Excision (OASIS)Not yet recruitingNCT071463346 countries
- Adaptive Anastomosis for Anterior Resection in Sigmoid and Proximal Rectal Cancer or Premalignant LesionsRecruitingNCT070563741 country
- Study of Colorectal Anastomosis Failures With First Sigmoid or Left Colonic Artery Preservation With D3 LymphadenectomyNot yet recruitingNCT06938490Not applicable1 country
- Resumption of Enteral Feeding After Bowel AnastomosisRecruitingNCT06906289Not applicable1 country
- Near-Infrared Fluorescence Imaging With Indocyanine Green to Evaluate Bowel Anastomoses in Gynecologic Oncology SurgeryNot yet recruitingNCT06871787Phase 41 country
- Evaluating the Effective and Safe Use of Stream™ PlatformNot yet recruitingNCT06522061Not applicable1 country
- AUGUR-AI - Indocyanine Green Fluorescence Angiography RepresenterNot yet recruitingNCT067088191 country
- Anastomotic Leakage After Right Hemicolectomy for Cancer, a Prospective Multicenter Study of SICO-CC NetworkRecruitingNCT066883831 country
- Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Patients After Pancreatic Procedures.Not yet recruitingNCT066726011 country
- A Novel Adaptive Anastomotic Technique for Left-sided Colonic ResectionNot yet recruitingNCT06615583Not applicable1 country
- Multi-Technology Integrated Total Mesorectal Excision Versus Conventional Total Mesorectal Excision for the Treatment of Middle and Distal Rectal Cancer.Not yet recruitingNCT06613399Not applicable
- Intraoperative Indocyanine Green Fluorescence Angiography in Colorectal Surgery to Prevent Anastomotic LeakageRecruitingNCT05168839Phase 31 country