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Not yet recruitingNCT07825246Updated Sep 17, 2026

Development and Clinical Validation of a Smart Analysis System for a Wearable Cardiac Ultrasound Device

An interventional study of Wearable Cardiac Ultrasound System in Cardiovascular Diseases, sponsored by Kunjing Pang. Not yet recruiting. Per ClinicalTrials.gov, last updated 2026-09-17.

Sponsored by Kunjing Pang · Not applicable, Interventional, and Diagnostic

Phase
Not applicable
Study type
Interventional
Enrollment
600
Allocation
Not applicable
Sex
All
01

Study summary

The goal of this observational study is to learn if a wearable heart ultrasound system with automated analysis works as well as standard bedside ultrasound for continuous heart function monitoring in adults and children with severe heart conditions in intensive care units (ICUs). The study will also test if the system can help guide minimally invasive procedures for structural heart defects. About 610 people will take part in this research.

The main questions it aims to answer are:

  • Do heart function measurements from the wearable ultrasound system match results from standard bedside ultrasound exams?
  • How accurately can the automated analysis tool measure heart function using images from the wearable device?
  • Is it feasible and safe to use the wearable ultrasound system to help guide minimally invasive closure of heart defects?

Researchers will compare readings collected by the wearable ultrasound device to results from standard bedside ultrasound exams. They will check how closely the two methods agree to see if the wearable system can replace standard testing for ongoing heart monitoring. The research team will remove all personal identifiers from all study data to protect each participant's privacy.

Participants will:

  • Wear a small, soft ultrasound patch on their chest to continuously monitor their heart structure and function
  • Receive standard bedside ultrasound exams as part of their routine intensive care
  • Allow the research team to collect their heart images and vital signs (heart rate, blood pressure, and oxygen levels) for study analysis
  • If they receive a minimally invasive procedure to fix a heart defect, the research team will use the wearable ultrasound device during the procedure to help guide treatment
02

Conditions studied

  • Cardiovascular Diseases

Keywords

  • Wearable ultrasound
  • Echocardiography
  • Artificial intelligence
  • Cardiac function monitoring
  • Structural heart disease
03

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Adult patients with perioperative cardiopulmonary critical illness admitted to the adult ICU or CCU at Fuwai Hospital, including patients with coronary artery disease or valvular heart disease after cardiac surgery, and patients undergoing interventional procedures for structural heart disease.
  • Pediatric patients with perioperative cardiopulmonary critical illness admitted to the pediatric intensive care unit (PICU) at Fuwai Hospital, including patients with congenital heart disease after cardiac surgery.

Exclusion criteria

Exclusion Criteria:

  • Severe wound infection or delayed thoracic closure that prevents placement of the wearable cardiac ultrasound monitoring device.
  • Patient or family refusal to participate in the study.
04

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
600 participants (estimated)

Study arms

  • Experimental
    Wearable Cardiac Ultrasound Monitoring

    Participants will undergo continuous cardiac structure and function monitoring with the wearable cardiac ultrasound system. They will also receive standard bedside echocardiography as routine clinical care. The study team will compare measurements from the wearable device with results from standard echocardiography to evaluate the accuracy and consistency of the wearable system.

    Device: Wearable Cardiac Ultrasound System

Interventions

  • DeviceWearable Cardiac Ultrasound System

    A soft, wearable ultrasound patch is applied to the participant's chest to continuously acquire cardiac ultrasound images. The system performs real-time 2D echocardiographic imaging, Doppler assessment, and automated cardiac function measurement. Ultrasound data is transmitted wirelessly for remote review by experienced sonographers, and synchronized with bedside vital sign monitors. Study staff compare measurements from the wearable system with results from standard bedside echocardiography to evaluate consistency and accuracy.

05

What researchers measure

Primary outcomes

  1. Mean Difference in LVEF Measurements Between Wearable Cardiac Ultrasound and Standard Bedside Echocardiography

    LVEF (%) measured from wearable cardiac ultrasound images will be compared with LVEF (%) measured by an experienced echocardiographer using standard bedside echocardiography. The primary outcome is the mean difference in LVEF between the two methods, calculated as wearable cardiac ultrasound minus standard bedside echocardiography. The mean difference and its 95% confidence interval will be calculated. Bland-Altman analysis will also be performed to estimate the 95% limits of agreement between the two methods.

    Time frame: Day 1

06

Study locations

No study locations are listed for this record.

07

References and documents

Publications

  • Zou F, Luo Y, Zhuang W, Xu T. A Fully Integrated Conformal Wearable Ultrasound Patch for Continuous Sonodynamic Therapy. Adv Mater. 2024 Sep;36(39):e2409528. doi: 10.1002/adma.202409528. Epub 2024 Aug 6. PubMed 39104292 ↗
  • Chu Y, Li C, Zhang W, et al. Human pulse diagnosis for medical assessments using a wearable piezoelectret sensing system. Adv Funct Mater. 2018 Oct;28(40):1803413.
  • Zhang L, Yu K, Wang Y, et al. A conformable phased-array ultrasound patch for bladder volume monitoring. Nat Electron. 2024 Jan;7(1):77-90.
  • Du W, Zhang L, Suh E, Lin D, Marcus C, Ozkan L, Ahuja A, Fernandez S, Shuvo II, Sadat D, Liu W, Li F, Chandrakasan AP, Ozmen T, Dagdeviren C. Conformable ultrasound breast patch for deep tissue scanning and imaging. Sci Adv. 2023 Jul 28;9(30):eadh5325. doi: 10.1126/sciadv.adh5325. Epub 2023 Jul 28. PubMed 37506210 ↗
  • Liu HC, Zeng Y, Gong C, Chen X, Kijanka P, Zhang J, Genyk Y, Tchelepi H, Wang C, Zhou Q, Zhao X. Wearable bioadhesive ultrasound shear wave elastography. Sci Adv. 2024 Feb 9;10(6):eadk8426. doi: 10.1126/sciadv.adk8426. Epub 2024 Feb 9. PubMed 38335289 ↗
  • Wang C, Chen X, Wang L, Makihata M, Liu HC, Zhou T, Zhao X. Bioadhesive ultrasound for long-term continuous imaging of diverse organs. Science. 2022 Jul 29;377(6605):517-523. doi: 10.1126/science.abo2542. Epub 2022 Jul 28. PubMed 35901155 ↗
  • Min S, An J, Lee JH, Kim JH, Joe DJ, Eom SH, Yoo CD, Ahn HS, Hwang JY, Xu S, Rogers JA, Lee KJ. Wearable blood pressure sensors for cardiovascular monitoring and machine learning algorithms for blood pressure estimation. Nat Rev Cardiol. 2025 Sep;22(9):629-648. doi: 10.1038/s41569-025-01127-0. Epub 2025 Feb 18. PubMed 39966649 ↗
  • Hu H, Huang H, Li M, Gao X, Yin L, Qi R, Wu RS, Chen X, Ma Y, Shi K, Li C, Maus TM, Huang B, Lu C, Lin M, Zhou S, Lou Z, Gu Y, Chen Y, Lei Y, Wang X, Wang R, Yue W, Yang X, Bian Y, Mu J, Park G, Xiang S, Cai S, Corey PW, Wang J, Xu S. A wearable cardiac ultrasound imager. Nature. 2023 Jan;613(7945):667-675. doi: 10.1038/s41586-022-05498-z. Epub 2023 Jan 25. PubMed 36697864 ↗
  • Sempionatto JR, Lin M, Yin L, De la Paz E, Pei K, Sonsa-Ard T, de Loyola Silva AN, Khorshed AA, Zhang F, Tostado N, Xu S, Wang J. An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers. Nat Biomed Eng. 2021 Jul;5(7):737-748. doi: 10.1038/s41551-021-00685-1. Epub 2021 Feb 15. PubMed 33589782 ↗
  • Wang C, Li X, Hu H, Zhang L, Huang Z, Lin M, Zhang Z, Yin Z, Huang B, Gong H, Bhaskaran S, Gu Y, Makihata M, Guo Y, Lei Y, Chen Y, Wang C, Li Y, Zhang T, Chen Z, Pisano AP, Zhang L, Zhou Q, Xu S. Monitoring of the central blood pressure waveform via a conformal ultrasonic device. Nat Biomed Eng. 2018 Sep;2(9):687-695. doi: 10.1038/s41551-018-0287-x. Epub 2018 Sep 11. PubMed 30906648 ↗

Individual participant data

Plan to share: No — Individual participant data will not be shared to protect the privacy and confidentiality of study participants. The dataset contains sensitive clinical medical records and identifiable cardiac imaging data of critically ill patients, which are governed by institutional data security policies and ethical review requirements. No external data sharing plan is designated for this study.

08

Registry details

Key details

Study ID
NCT07825246
Lead sponsor
Kunjing Pang
Responsible party
Kunjing Pang (Principal Investigator, China National Center for Cardiovascular Diseases) — Sponsor-investigator
First posted
Sep 17, 2026
Start date
Sep 5, 2026 (estimated)
Primary completion
Sep 5, 2028 (estimated)
Completion
Mar 16, 2029 (estimated)
Last update
Sep 17, 2026

Study contacts

Kunjing Pang
Contact
pangkunjing2020@126.com
13520114557

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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