An observational study in Upper Respiratory Infection, Pediatric Surgical Patients and Perioperative Respiratory Adverse Events, sponsored by Brittany Willer. Not yet recruiting. Open to participants aged 0 Years to 18 Years. Per ClinicalTrials.gov, last updated 2026-09-14.
Sponsored by Brittany Willer · Observational
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The objective of this study is to determine the prevalence of asymptomatic viral carriers among healthy surgical patients and to describe the demographic and clinical characteristics of these patients. The secondary objective is to compare the incidence of perioperative respiratory adverse events (PRAE) between virus positive patients with and without upper respiratory infection (URI) symptoms. The secondary objective would aim to enroll patients who report recent URI symptoms.
The primary endpoint is to determine the prevalence of asymptomatic viral carriers among healthy pediatric surgical patients and describe the demographic and clinical characteristics of these patients. This will be done using prospectively collected respiratory swabs from healthy asymptomatic children undergoing elective pediatric surgery. This will result in a quantifiably proportion of children who test positive for respiratory viruses. This aim will define the epidemiologic baseline of silent viral URIs in children undergoing elective surgery. We can then evaluate the association between asymptomatic viral infections and perioperative respiratory adverse events (PRAEs). A secondary endpoint will be to compare the incidence of PRAE between virus positive patients with and without URI symptoms. This will be done by prospectively enrolling patients who report recent (within 2 weeks) or current URI symptoms.
753 studies on the registry are indexed under Respiratory Tract Infections; 114 are open to participants now.
This study's planned enrollment of 300 is below the median of 350 across 184 observational studies indexed under Respiratory Tract Infections.
Browse Respiratory Tract Infections studies →Brittany Willer is the lead sponsor of 5 studies on the registry; 4 are open to participants now.
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Patients \<18 presenting at NCH for elective ambulatory procedures under general anesthesia.
100 patients who are asymptomatic for URI symptoms 200 patients who report recent (within 2 weeks) or current URI symptoms.
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Exclusion Criteria:
Pediatric patients who report recent (within two weeks) or current URI symptoms presenting for surgery
Diagnostic Test: Mid-turbinate nasal swab
Healthy pediatric patients without respiratory symptoms scheduled for surgery
Diagnostic Test: Mid-turbinate nasal swab
Mid-turbinate nasal swab for viral testing using a PCR film array test (qRT-PCR).
Result from mid-turbinate nasal swab to test of viruses that cause URI by qRT-PCR test.
All patients will be tested for the presence of viruses that cause upper respiratory infections by taking a mid-turbinate nasal swab and using a PCR film array test.
Time frame: From enrollment to the end of the surgery, no more than 8 hours.
Association between asymptomatic viral infections and perioperative respiratory adverse events (PRAEs).
Occurrence of PRAE during or after surgery.
Time frame: Time of enrollment to time of hospital discharge, no more than 24 hours.
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Sep 2026; primary completion for Dec 2029, 39 months later.
Of 66 non-industry observational studies under Respiratory Tract Infections, half reached primary completion within 25 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 48. This study's planned 39 months is above that.
Counting every sponsor, half of 85 studies reached it within 18 months; a quarter within 8 and three quarters within 42.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Respiratory Tract Infections →
Brittany Willer