An interventional study of Physical Activity Education in Obstructive Sleep Apnea, Sleep Quality and Respiratory Function, sponsored by Medipol University. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-22.
Sponsored by Medipol University · Not applicable, Interventional, and Treatment
Although exercise and physical activity have shown beneficial effects in individuals with obstructive sleep apnea (OSA), evidence regarding the effects of daily physical activity habits on sleep quality and respiratory parameters remains limited. This study aims to investigate these associations in individuals with OSA.
Obstructive sleep apnea (OSA) is a common sleep disorder characterized by recurrent upper airway collapse during sleep, leading to apneas and hypopneas. OSA negatively affects sleep quality, daytime functioning, and overall health and is associated with cardiovascular and metabolic disorders. Although continuous positive airway pressure (CPAP) is the primary treatment, adherence may be challenging. Physical activity and exercise have shown beneficial effects on OSA symptoms, sleep quality, and respiratory function. However, evidence regarding the relationship between habitual daily physical activity and these outcomes remains limited. Therefore, this study aims to investigate the effects of physical activity habits on sleep quality and respiratory parameters in individuals with OSA.
2,263 studies on the registry are indexed under Sleep Apnea, Obstructive; 465 are open to participants now.
This study's planned enrollment of 48 is close to the median of 53 across 1,490 interventional studies indexed under Sleep Apnea, Obstructive.
Browse Sleep Apnea, Obstructive studies →Medipol University is the lead sponsor of 320 studies on the registry; 87 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants will continue using physician-prescribed continuous positive airway pressure (CPAP) therapy and will be instructed to use CPAP every night for 24 weeks. No additional physical activity education will be provided as part of the study intervention.
Participants will receive physical activity education at baseline, supported by visual materials and brochures. The education will include moderate-intensity aerobic and muscle-strengthening activities in accordance with established physical activity guidelines. Participants will be contacted periodically to assess adherence to physical activity recommendations. Participants will continue their prescribed CPAP therapy throughout the 24-week study period.
Behavioral: Physical Activity Education
Participants will receive physical activity education supported by illustrated materials and brochures. Recommendations will include: (1) aerobic exercise, with at least 150 minutes of moderate-intensity activity weekly (e.g., walking or cycling) over at least 3 days; (2) muscle-strengthening exercises targeting major muscle groups 2-3 days per week, with 3 sets of 8-15 repetitions; (3) balance and flexibility exercises 3 days per week; and (4) diaphragmatic breathing exercises for 15-30 minutes per session, 3 days per week. Exercise sessions will include 5-10 minutes of warm-up and cool-down. Periodic follow-up contacts will encourage adherence throughout the 24-week intervention. All participants will continue prescribed CPAP therapy.
Pittsburgh Sleep Quality Index (PSQI)
A 19-item self-report questionnaire assessing sleep quality and disturbances over the previous month, including sleep duration, latency, efficiency, and daytime dysfunction. Total scores range from 0 to 21, with higher scores indicating poorer sleep quality. Scores above 5 indicate poor sleep quality.
Time frame: 0.,12., and 24. weeks
CPAP Adherence Data
CPAP device data will be downloaded to assess average nightly usage, mask leak, and treatment pressure. Good adherence will be defined as CPAP use for at least 4 hours per night on at least 5 nights per week.
Time frame: 0., and 24. weeks
MIP-MEP measurement
In centimeters of water (cmH2O), it will be obtained using a Respiratory Muscle Strength Measurement Device-MIP-MEP (MD Diagnostics Ltd., RP Check, United Kingdom) in accordance with the recommendations of the American Thoracic Society.
Time frame: 0.,12., and 24. weeks
Forced Vital Capacity (FVC) measurement
It is the amount of air expelled after maximum inspiration following a normal breath, expressed in liters. While healthy individuals can forcefully exhale air for 2-3 seconds, this time can be as short as 10-15 seconds for individuals with airway problems. At the end of the test, the expected reference value should be between 80-120%. This will be performed using a spirometer (Cosmed, Pony FX, Italy). The best forced vital capacity (FVC) maneuver from at least 3 attempts will be selected according to the criteria of the American Thoracic Society. To perform the spirometric maneuvers, participants will sit upright with their feet on the floor and the nose clip correctly positioned.
Time frame: 0.,12., and 24. weeks
FEV₁ (Forced Expiratory Volume in 1 Second)
It is the volume of air exhaled in the first second after forced expiration. Although measured in liters, it actually indicates the airflow rate. In healthy individuals, at least 72% of the air should be exhaled, reflecting the function of the large airways. This will be performed using a spirometer (Cosmed, Pony FX, Italy). To perform the spirometric maneuvers, participants will sit upright with their feet on the floor and the nose clip correctly positioned.
Time frame: 0.,12., and 24. weeks
FEV1/FVC ratio
This ratio is obtained by dividing FEV1 by FVC and evaluates airway patency and lung function. In a normal individual, this ratio is around 70-80%. This will be performed using a spirometer (Cosmed, Pony FX, Italy). To perform the spirometric maneuvers, participants will sit upright with their feet on the floor and the nose clip correctly positioned.
Time frame: 0.,12., and 24. weeks
FEF 25%-75% (Maximal Mid-Expiratory Flow Rate
It refers to the average airflow rate during forced expiration, when 25% to 75% of the volume is expelled. It is measured in liters per second. It reflects the function of the medium and small airways. A value above 80% of the reference value is normal. This will be performed using a spirometer (Cosmed, Pony FX, Italy). To perform the spirometric maneuvers, participants will sit upright with their feet on the floor and the nose clip correctly positioned.
Time frame: 0.,12., and 24. weeks
Baecke Habitual Physical Activity Questionnaire (BHPAQ)
16-item self-report questionnaire assessing habitual physical activity over the previous year across three domains: occupational activity (8 items), sports activity (4 items), and leisure-time activity (4 items). The total score is calculated by summing the three domain scores.
Time frame: 0.,12., and 24. weeks
International Physical Activity Questionnaire-Short Form (IPAQ-SF)
The IPAQ-SF assesses vigorous and moderate physical activity, walking, and sitting time. Total physical activity is calculated as MET-minutes/week, and participants are classified as having low, moderate, or high activity levels.
Time frame: 0. week
Insomnia Severity Index (ISI)
7-item self-report questionnaire assessing insomnia severity and its impact on daily functioning. Total scores range from 0 to 28, with higher scores indicating more severe insomnia symptoms.
Time frame: 0.,12., and 24. weeks
Epworth Sleepiness Scale (ESS)
An 8-item self-report questionnaire assessing the likelihood of dozing during daily activities. Total scores range from 0 to 24, with higher scores indicating greater daytime sleepiness. Scores above 10 suggest excessive daytime sleepiness.
Time frame: 0.,12., and 24. weeks
Functional Outcomes of Sleep Questionnaire-Short Form (FOSQ-10)
A 10-item self-report questionnaire assessing the impact of sleepiness on daily activities, productivity, activity level, social functioning, and intimate relationships. Total scores range from 5 to 20, with higher scores indicating better functional status.
Time frame: 0.,12., and 24. weeks
Subjective Sleepiness and Sleep Quality
Subjective sleepiness will be assessed three times daily (09:00, 12:00, and 20:00) using a 0-10 visual analogue scale (VAS), with higher scores indicating greater sleepiness. Subjective sleep quality will be assessed daily upon awakening using a 0-10 VAS, with higher scores indicating better sleep quality.
Time frame: 0.,12., and 24. weeks
Chalder Fatigue Scale (CFS)
An 11-item questionnaire assessing physical and mental fatigue in adults. Items are rated on a 4-point Likert scale, with higher scores indicating greater fatigue severity.
Time frame: 0.,12., and 24. weeks
Hospital Anxiety and Depression Scale (HADS)
A 14-item self-report questionnaire assessing anxiety and depression symptoms, with separate 7-item subscales. Each subscale is scored from 0 to 21, with higher scores indicating greater symptom severity. Turkish cut-off scores are 10 for anxiety and 7 for depression.
Time frame: 0.,12., and 24. weeks
Short Form Health Survey (SF-12)
A 12-item questionnaire assessing health-related quality of life across physical and mental health domains. Physical Component Summary (PCS-12) and Mental Component Summary (MCS-12) scores range from 0 to 100, with higher scores indicating better health status.
Time frame: 0.,12., and 24. weeks
Quadriceps Isometric Muscle Strength
Unilateral isometric knee extension strength will be measured using a handheld dynamometer. Participants will sit with their hips and knees flexed at 90°. Three trials will be performed on each side, and the highest value will be recorded in kilogram-force (kgf).
Time frame: 0.,12., and 24. weeks
Handgrip Strength
Dominant handgrip strength will be measured using a Jamar hydraulic hand dynamometer. Participants will sit upright with the elbow flexed at 90° and the forearm in a neutral position. Three trials will be performed with 2-minute rest intervals, and the highest value will be recorded.
Time frame: 0.,12., and 24. weeks
Physical Activity Diary
Participants will record their daily physical activities, including activity type, duration, and perceived exertion, to monitor adherence to physical activity recommendations throughout the study.
Time frame: 0.,12., and 24. weeks
Start is estimated for Nov 2026; primary completion for Jun 2027, 7 months later.
Of 511 non-industry interventional studies with no phase under Sleep Apnea, Obstructive, half reached primary completion within 32 months of starting (the median), counting those still running; a quarter within 16 and three quarters within 53. This study's planned 7 months is below that.
Counting every sponsor, half of 621 studies reached it within 26 months; a quarter within 12 and three quarters within 50.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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