An interventional study of Stemregen in Male Infertility and Oligoasthenospermia, sponsored by Kocaeli University. Completed at 1 site in Turkey (Türkiye). Open to male participants aged 20 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-09-02.
Sponsored by Kocaeli University · Not applicable, Interventional, and Treatment
This study evaluated whether Stemregen® dietary supplementation could improve sperm quality and assisted reproductive treatment outcomes in men with severe oligoasthenozoospermia who had previously experienced at least one failed intracytoplasmic sperm injection (ICSI) attempt. A total of 60 men were included and divided into a treatment group and a control group. Participants in the treatment group received Stemregen® dietary supplementation for 3 months, while the control group received no additional treatment. Semen parameters, sperm DNA fragmentation, fertilization, embryo transfer, and pregnancy outcomes were evaluated and compared between the groups.
Inclusion Criteria:men aged 20-50 years with severe oligoasthenozoospermia, defined for the purposes of the study as a sperm concentration \<5 × 10⁶/mL with markedly reduced progressive motility, and at least one previous unsuccessful intracytoplasmic sperm injection (ICSI) cycle. -
Exclusion Criteria:clinically significant varicocele requiring surgical correction, obstructive azoospermia, hypogonadotropic hypogonadism, primary testicular failure, chromosomal abnormalities or known genetic causes of infertility, active genitourinary infection, uncontrolled diabetes mellitus, severe systemic disease, malignancy, previous chemotherapy or pelvic radiotherapy, and hormonal or antioxidant treatment within the preceding three months. Female partners underwent routine infertility evaluation, and couples with severe female infertility factors, including diminished ovarian reserve, advanced endometriosis, major uterine abnormalities, or severe ovulatory dysfunction
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participants received standard-dose Stemregen®dietary supplementatıon for 3 months
Dietary Supplement: Stemregen
participants received no additional treatment during the study period
participants received standard-dose Stemregen® dietary supplementatıon for 3 months
Change in Sperm Count
Change in Sperm Count from baseline to after 3 months of Stenregen supplementation,assessed by semen analysis
Time frame: Baseline and 3 months
This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Kocaeli University