An interventional study of Exercise at 22°C and Exercise at 26°C in Body Temperature Changes, Heat Stress and Child Development, sponsored by University of Ottawa. Recruiting at 1 site in Canada. Open to participants aged 9 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-10.
Sponsored by University of Ottawa · Not applicable, Interventional, and Basic science
Little is known about how children and youth regulate body temperature during exercise across different environmental temperatures compared with young adults, including whether differences in whole-body heat exchange contribute to their responses. The goal of this clinical trial is to determine how ambient temperature affects thermoregulation during exercise in boys and girls aged 9-16 years compared with young adult men and women aged 20-25 years. Participants will complete four study visits at ambient temperatures of 22°C (Celsius; 72°F, Fahrenheit), 26°C (79°F), 31°C (88°F), and 36°C (97°F), while exercising at the same moderate-intensity metabolic heat production of 160 W/m² (W = watts, m = meters). During each visit, participants will complete four 15-minute periods of exercise (exercise bouts 1, 2, 3 and 4 respectively) separated by 15-minute rest periods. Testing will be performed in a whole-body air calorimeter, a specialized chamber that precisely measures heat lost through evaporation and dry heat exchange and the amount of heat stored in the body. These measurements, together with core temperature and heart rate, will allow researchers to determine how increasing ambient temperature affects the body's ability to lose heat and whether these responses differ between children and youth and young adults.
97 studies on the registry are indexed under Body Temperature Changes; 20 are open to participants now.
This study's planned enrollment of 12 is below the median of 40 across 68 interventional studies indexed under Body Temperature Changes.
Browse Body Temperature Changes studies →University of Ottawa is the lead sponsor of 125 studies on the registry; 34 are open to participants now.
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Exclusion Criteria:
Participants will complete intermittent moderate-intensity exercise at an ambient temperature of 22°C (celsius; 72°F, fahrenheit). Exercise will be performed at a metabolic heat production of 160 W/m² (W = watts, m = meters) and will consist of four 15-minute exercise periods separated by 15-minute rest periods. Exercise workload will be individually adjusted to achieve the prescribed metabolic heat production.
Other: Exercise at 22°C
Participants will complete intermittent moderate-intensity exercise at an ambient temperature of 26°C (79°F). Exercise will be performed at a metabolic heat production of 160 W/m² and will consist of four 15-minute exercise periods separated by 15-minute rest periods. Exercise workload will be individually adjusted to achieve the prescribed metabolic heat production.
Other: Exercise at 26°C
Participants will complete intermittent moderate-intensity exercise at an ambient temperature of 31°C (88°F). Exercise will be performed at a metabolic heat production of 160 W/m² and will consist of four 15-minute exercise periods separated by 15-minute rest periods. Exercise workload will be individually adjusted to achieve the prescribed metabolic heat production.
Other: Exercise at 31°C
Participants will complete intermittent moderate-intensity exercise at an ambient temperature of 36°C (97°F). Exercise will be performed at a metabolic heat production of 160 W/m² and will consist of four 15-minute exercise periods separated by 15-minute rest periods. Exercise workload will be individually adjusted to achieve the prescribed metabolic heat production.
Other: Exercise at 36°C
Participants complete intermittent exercise at a metabolic heat production of 160 W/m² in an ambient temperature of 22°C (72°F).
Participants complete intermittent exercise at a metabolic heat production of 160 W/m² in an ambient temperature of 26°C (79°F).
Participants complete intermittent exercise at a metabolic heat production of 160 W/m² in an ambient temperature of 31°C (88°F).
Participants complete intermittent exercise at a metabolic heat production of 160 W/m² in an ambient temperature of 36°C (97°F).
Core temperature
Core temperature indexed by visceral (telemetry pill) temperature
Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)
Evaporative heat loss
Evaporative heat loss as assessed using a direct air calorimeter
Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)
Dry heat loss
Dry heat loss as assessed using a direct air calorimeter
Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)
Whole-body total heat loss
Total heat loss (evaporative + dry) as assessed using a direct air calorimeter
Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)
Body heat storage
Heat stored in the body for each of the exercise bouts
Time frame: Change from start to end of exercise for each of the four 15 minutes exercise bouts
Skin temperature
Skin temperature measured at 8-sites (forehead, chest, scapula, upper arm, forearm, hand, thigh, calf) with mean value calculated as weighted values of 8 sites - forehead 7%, chest 17.5%, scapula 17.5%, upper arm 7%, forearm 7%, hand 5%, thigh 19%, and calf 20%.
Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)
Change in skin temperature
Skin temperature measured at 8-sites (forehead, chest, scapula, upper arm, forearm, hand, thigh, calf) with mean value calculated as weighted values of 8 sites - forehead 7%, chest 17.5%, scapula 17.5%, upper arm 7%, forearm 7%, hand 5%, thigh 19%, and calf 20%.
Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)
Heart rate
Heart rate measured continuously with chest-band telemetric device
Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)
Thermal sensation
Thermal sensation will be assessed using the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE) 7-point scale ("0=neutral to 7=extremely hot")
Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)
Started Jul 2026 (actual). Primary completion is estimated for Apr 2027, 9 months after the start.
Of 44 non-industry interventional studies with no phase under Body Temperature Changes, half reached primary completion within 5 months of starting (the median), counting those still running; a quarter within 3 and three quarters within 21. This study's planned 9 months is above that.
Counting every sponsor, half of 44 studies reached it within 5 months; a quarter within 3 and three quarters within 21.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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