ClinicalTrials.gg
CompletedNCT07778628Updated Aug 21, 2026

WT1 in Colorectal Adenocarcinoma

An observational study in Colorectal Cancer, sponsored by Sohag University. Completed at 1 site in Egypt. Per ClinicalTrials.gov, last updated 2026-08-21.

Sponsored by Sohag University · Observational

Study type
Observational
Model
Case-only
Time perspective
Cross-sectional
Enrollment
60
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 54 studies in Colorectal Neoplasms with a site in Egypt — 15 open to participants now, 16 under way, 5 of them phase 3. Colorectal Neoplasms · Egypt.

Enrollment
15th of 22
60 · median 93
Started
2022
with 8 others
Observational
22 of 54
4 open now
Registered
52nd of 54
by date
Lead sponsor
6 of 54
Sohag University

Among the 54 studies in Colorectal Neoplasms with a site in Egypt, this one is the 15th largest by enrollment of the 22 observational ones that give a count, is one of 9 that started in 2022, is one of 22 observational ones, and was the 52nd registered.

Colorectal Neoplasms

6,541 studies on the registry are indexed under Colorectal Neoplasms; 1,667 are open to participants now.

Browse Colorectal Neoplasms studies →

Open to participants now

15 of the 54 studies in Colorectal Neoplasms with a site in Egypt are open now. Recruiting first, the newest first:

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All 15 open studies →

A study can be open while its sites in Egypt have not opened yet or have stopped. Only those recruiting at a site in Egypt →

Who these studies take

Of the 1,185 Colorectal Neoplasms studies recruiting now, 769 (65%) set no upper age limit and 265 (22%) stop at 75 or younger; 48 take children under 18; 123 take healthy volunteers.

This study: all sexes · no healthy volunteers.

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02

Study summary

Colorectal carcinoma is a major bublic health problem. It is due to several genetic mutations. Wilms' tumor1 (WT1) gene is a tumor suppressor gene that has been mutated in several human tumors. Detection of WT1 in colorectal carcinoma may provide better future results.

Read the detailed description

Colorectal adenocarcinoma represents one third of human caners worldwide. It results from cumulative genetic mutations. the incidence of colorectal carcinoma is rising, so, detecting new therapeutic modalities is important. Wilms' Tumor 1 (WT1) gene is a tumor suppressor gene. in certain tumors; WT1 acts as an oncogene, facilitating tumor growth and spread. WT1 is also involved in angiogenesis. we decided to detect expression of WT1 in 60 patients with colorectal adenocarcinoma and detect any association between WT1 expression and certain tumor oarameters as perineural invasion, lymphovascular invasion, lymph node metastasis.

03

Conditions studied

  • Colorectal Cancer

Keywords

  • Wilms' tumor 1
  • Cancer colon
  • Angiogenesis
  • Immunohistochemistry
04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

a retrospective, observational study.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • patients with colorectal adenocarcinoma.

Exclusion criteria

Exclusion Criteria:

  • patients who received pre-operative therapy.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Adjuvant and neoadjuvant

Neoadjuvant treatment is given before the main treatment (usually surgery), often to shrink a tumour. Adjuvant treatment is given after it, to lower the chance of the cancer coming back.

05

Study design

Observational model
Case-only
Time perspective
Cross-sectional
Enrollment
60 participants (actual)
Target follow-up
6 Months
Patient registry
Yes

Groups and cohorts

  • 60 cases of colorectal carcinoma

    60 formalin fixed, paraffin embedded tissue blocks belonged to patients with colorectal cancer. sections will be obtained and stained immunohistochemically with anti WT1 antibody.

    Biological: immunohistochemical staining with WT1 antibody

Interventions

  • Biologicalimmunohistochemical staining with WT1 antibody

    4 micrometer thick tissue sections will be stained by anti humal WT1 immunohistochemical antibody.

06

What researchers measure

Primary outcomes

  1. detection of WT1 in colorectal adenocarcinoma

    detection of WT1 in colorectal adenocarcinoma and correlate its expression in tumor cells with certain parameters as patients ages, sexes, tumor grade, lymph node metastasis, lymphovascular invasion and perineural invasion.

    Time frame: 6 months

07

Study locations

1 site
  • Faculty of Medicine, Sohag University
    Sohag, Egypt
08

References and documents

Related links

Individual participant data

Plan to share: Undecided

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jan 2022 to primary completion in Dec 2025, 47 months.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 18, 2026
First posted
Aug 21, 2026
StartActual
Jan 15, 2022
Primary completionActual
Dec 15, 2025
CompletionActual
Jun 30, 2026
Last update
Aug 21, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 21, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07778628
Lead sponsor
Sohag University
Responsible party
Maisa Hashem Mohammed (Assistant Professor, Sohag University) — Principal investigator
First posted
Aug 21, 2026
Start date
Jan 15, 2022
Primary completion
Dec 15, 2025
Completion
Jun 30, 2026
Last update
Aug 21, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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