An interventional study of Electrical Stimulation in Cochlear Hearing Loss, Hearing Loss, Sensorineural and Hearing Loss, sponsored by Cambridge University Hospitals NHS Foundation Trust. Enrolling by invitation at 1 site in United Kingdom. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-12.
Sponsored by Cambridge University Hospitals NHS Foundation Trust · Not applicable, Interventional, and Diagnostic
Among 22 studies in Hearing Loss, Sensorineural with a site in United Kingdom — 8 open to participants now, 8 under way, 1 of them phase 3. Hearing Loss, Sensorineural · United Kingdom.
Among the 22 studies in Hearing Loss, Sensorineural with a site in United Kingdom, this one is the 8th largest by planned enrollment of the 11 interventional ones that give a count, is one of 6 that started in 2019, is one of 8 with no phase, and was the 8th registered.
346 studies on the registry are indexed under Hearing Loss, Sensorineural; 101 are open to participants now.
Browse Hearing Loss, Sensorineural studies →8 of the 22 studies in Hearing Loss, Sensorineural with a site in United Kingdom are open now. Recruiting first, the newest first:
Advanced Bionics AG · Sites in United Kingdom, Belgium, France and 4 more countries
Ages 18+
Eli Lilly and Company · Sites in United Kingdom, United States, Canada and 1 more country
Guy's and St Thomas' NHS Foundation Trust · Sites in United Kingdom
Ages 8–16
Regeneron Pharmaceuticals · Sites in United Kingdom, United States, Germany and 2 more countries
Akouos, Inc. · Sites in United Kingdom, United States, Australia and 4 more countries
Ages up to 44
A study can be open while its sites in United Kingdom have not opened yet or have stopped. Only those recruiting at a site in United Kingdom →
Of the 70 Hearing Loss, Sensorineural studies recruiting now, 39 (56%) set no upper age limit and 19 (27%) stop at 75 or younger; 26 take children under 18; 17 take healthy volunteers.
This study: 18 Years and older · all sexes · healthy volunteers too.
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22 studies; the count open now beside each. This study's row is marked.
First in 2015; this study’s year is marked. 6 started in 2019.
This study's planned enrollment of 24 is below the median of 32 across 247 interventional studies indexed under Hearing Loss, Sensorineural.
Median enrollment 36 across the 11 interventional studies, 52 across the 11 observational. Of the 9 that completed or were terminated, 0 (0%) have results posted.
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7 of 22 have an industry lead sponsor. The 10 most frequent:
Cambridge University Hospitals NHS Foundation Trust is the lead sponsor of 171 studies on the registry; 38 are open to participants now.
Cambridge University Hospitals NHS Foundation Trust has 3 studies filed under Hearing Loss, Sensorineural — fewer than ten, so there is no comparison to draw.
3 of the studies in Hearing Loss, Sensorineural with a site in United Kingdom that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06268340Advanced Bionics AGHearing and Structure Preservation Via ECochG | 2026-12-31 |
| NCT04161261Cambridge University Hospitals NHS Foundation TrustMinimizing Facial Nerve Stimulation in Cochlear Implants | 2027-05-03 |
| NCT07895004University College, LondonComparing an AI-driven Hearing Test With the Standard Hearing Test in Adults With Hearing Loss and Tinnitus | 2027-08-23 |
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Among the 22 studies in Hearing Loss, Sensorineural with a site in United Kingdom, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This study aims to understand how to manipulate the electrical stimulation from the cochlear implant to maximize hearing stimulation and minimize facial stimulation. It is know from animal data that the hearing and facial nerves have different sensitivities to things like electrical pulse shape, its pattern, and its duration. It is very unclear however if this applies to human cochlear implant patients, and what the optimal parameters are to selectively stimulate the hearing nerve in humans. The outcomes of this study will be used to more selectively program some patients with severe facial nerve cross stimulation and to inform the development of new types of implant stimulation.
The patients eligible for the study are deaf, and have consented as part of their standard of care to receiving a cochlear implant. There will be no interference with this process in any way. Those patients that are unfortunate to be affected by facial nerve stimulation following receiving their cochlear implant however will be contacted and with the aim to help improve their symptoms as indicated in prior animal studies
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Participant is willing and able to give for participation in the study.
Exclusion Criteria:
Unstable cochlear implant or hearing aid fitting
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The intra-operative group consists of patients who have met criteria for cochlear implants. We monitor the facial nerve EMG intraoperatively in all patients, and often get some facial nerve activation when we are testing the implant intraoperatively when we are looking to see if we are getting any hearing nerve responses from electrical stimulation of the implant. We will also measure the facial nerve responses for some other charge-balanced pulse shapes, which are asymmetric and in which either the positive or negative charge is expected to stimulate the nerve. We will only measure these for two electrodes, not for all 12-22 electrodes They will be then invited back post operatively for a second testing during a standard of care visit post switch on for other pulse shapes.
Procedure: Electrical Stimulation
The post-operative group, are patients who are actually having facial nerve stimulation on one or more electrodes, and for whom these electrodes are turned down so much they can't hear very well, or are actually turned off because of the facial nerve stimulation. For these patients, we will slowly increase the current levels on the offending electrodes (maximum of two) until they get some facial nerve twitching, and then turn down the current until they do not have stimulation any more. We will do this for all pulse shapes and determine which shape produces the greatest loudness without stimulating the facial nerve. This will be the only testing session for the second group.
Procedure: Electrical Stimulation
To measure the facial nerve stimulation threshold for one mid-array and one apical electrode of the implant using the pulse-train stimuli
To identify stimulus parameters for cochlear implant stimulation that achieve sufficient loudness for hearing, while minimizing stimulation of the facial nerve.
The loudness level, or auditory nerve response at which facial nerve stimulation occurs for different stimulation pulse shapes will be measured for all 24 patients on both groups and help to identify different optimal stimulus parameters. By comparing the amount of electrical current required to initiate a facial nerve response for each pulse shape this will determine if there is an optimal type of stimulation to use, to reduce facial nerve stimulation.
Time frame: 18 months
To increase scientific understanding of the biology of the auditory and facial nerve's responses to stimulation.
This is a hugely under researched field where we are pioneering techniques and so exact outcome measures may be difficult to quantify in this scientific investigation. We are not able to use questionnaires or scientific tools at this stage, however this can be measured through electrical current measurements on the volta software for the Advanced Bionics cochlear implant company.
Time frame: 18 months
Plan to share: No — Upon completion of study, data will be disseminated into research community anonymised. IPD will not be accessible to researchers outside the clinical care team.
No publications or documents are linked to this record.
Started Dec 2019 (actual). Primary completion is estimated for May 2027, 88 months after the start.
Of 82 non-industry interventional studies with no phase under Hearing Loss, Sensorineural, half reached primary completion within 33 months of starting (the median), counting those still running; a quarter within 18 and three quarters within 83. This study's planned 88 months is above that.
Counting every sponsor, half of 162 studies reached it within 22 months; a quarter within 6 and three quarters within 44.
Since we started tracking on Sep 25, 2026, the dates moved once, on Nov 12, 2026: primary completion May 2022 → May 2027 and completion Nov 2022 → Nov 2028.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Cambridge University Hospitals NHS Foundation Trust →