An observational study in Gingival Recessions, sponsored by Marmara University. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-20.
Sponsored by Marmara University · Observational
Among 69 studies in Gingival Recession with a site in Turkey — 14 open to participants now, 15 under way, none of them phase 3. Gingival Recession · Turkey.
Among the 69 studies in Gingival Recession with a site in Turkey, this one is the 10th largest by planned enrollment of the 13 observational ones, is one of 10 that started in 2025, is one of 13 observational ones, reaches primary completion later than 10 of the 14 other live ones, and was the 67th registered.
426 studies on the registry are indexed under Gingival Recession; 106 are open to participants now.
This study's planned enrollment of 36 is below the median of 48 across 31 observational studies indexed under Gingival Recession.
Browse Gingival Recession studies →14 of the 69 studies in Gingival Recession with a site in Turkey are open now, in 1 country. Each count lists the studies.
Of the 64 Gingival Recession studies recruiting now, 30 (47%) set no upper age limit and 31 (48%) stop at 75 or younger; 1 take children under 18; 36 take healthy volunteers.
This study: 18 Years to 65 Years · all sexes · healthy volunteers too.
The full table on the hub →69 studies; the count open now beside each. This study's row is marked.
First in 2010; this study’s year is marked. 10 started in 2025.
Median enrollment 36 across the 56 interventional studies, 80 across the 13 observational. Of the 52 that completed or were terminated, 0 (0%) have results posted.
None of the 69 has an industry lead sponsor. The 10 most frequent:
Marmara University is the lead sponsor of 599 studies on the registry; 138 are open to participants now.
Marmara University has 3 studies filed under Gingival Recession — fewer than ten, so there is no comparison to draw.
4 of the studies in Gingival Recession with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07804888Saglik Bilimleri UniversitesiEvaluation of the Effects of Injectable Platelet-Rich Fibrin and Hyaluronic Acid Treatments, Administered in Addition to Free Gingival Graft Therapy, on Clinical Healing. | 2027-01 |
| NCT07777185Ankara UniversityEvaluation of the Effect of Smoking on Palatal Donor Site Tissue Profile in the Success of Connective Tissue Grafts | 2027-02-20 |
| NCT07349056Trakya UniversityEarly Effects of Orthognathic Surgery on Periodontal Phenotype: A 6-Month Prospective Clinical and Radiographic Evaluation | 2027-02-23 |
| NCT07751211Altinbas UniversityEffects of Low-Level Laser Therapy and Hyaluronic Acid After Free Gingival Graft | 2027-03-06 |
Among the 69 studies in Gingival Recession with a site in Turkey, from their registry updates:
This study evaluates whether the outcome of root coverage surgery can be predicted from a preoperative intraoral photograph. Adults with Cairo RT1,RT2 or RT3 gingival recessions treated with a coronally advanced flap and a connective tissue graft are followed for six months. Standardised photographs and clinical measurements are obtained before surgery and at each follow-up visit. A deep learning model is developed to predict the surgical outcome from the preoperative photograph and baseline clinical variables, and its performance is compared with the outcome measured clinically at six months. The model does not influence treatment decisions.
Whether an exposed root surface can be completely covered is the central question in planning mucogingival surgery. The Cairo classification is the current diagnostic standard for that judgement, but assignment of the recession type varies between examiners and prediction of the individual surgical outcome remains largely subjective. In this cohort, consecutive systemically healthy adults with Cairo RT1,RT2 or RT3 gingival recessions are treated by a single operator with a coronally advanced flap combined with a subepithelial connective tissue graft. Recession depth, keratinised tissue width and gingival thickness are recorded at baseline and at three and six months.
Standardised intraoral photographs are obtained at each time point under fixed conditions. A deep learning model is developed to predict the six-month outcome from the preoperative photograph together with baseline clinical variables. Model performance is assessed by discrimination, calibration and prediction error, using the clinical measurement at six months as the reference standard. A secondary analysis examines whether the recession type assigned automatically from the photograph agrees with the type assigned by the examining periodontist. The model is developed and validated internally within this cohort; no external validation set is available. Its output is not shown to the operator and does not influence treatment. Reporting follows the TRIPOD recommendations for prediction model studies.
The study population consists of systemically healthy adult patients (aged 18-65) presenting to the Department of Periodontology at Marmara University with esthetic concerns or dentin hypersensitivity associated with gingival recession. The cohort includes individuals diagnosed with Cairo Class RT1 or RT2 (Miller Class I or II) gingival recession defects who are scheduled to undergo mucogingival root coverage surgery.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Systemically healthy adults aged 18 to 65 years with Cairo RT1,RT2 pr RT3 gingival recessions, treated with a coronally advanced flap combined with a subepithelial connective tissue graft by a single operator and followed for six months. All participants received the same surgical technique; no comparison group was formed and no participant was assigned to a treatment for the purposes of this study. Standardised intraoral photographs and clinical measurements were obtained before surgery and at three and six months.
Procedure: Coronally advanced flap with subepithelial connective tissue graft · Diagnostic Test: Deep learning based prediction of root coverage outcome
A coronally advanced flap is raised over the recession defect and a subepithelial connective tissue graft harvested from the palate is positioned beneath it, after which the flap is sutured coronal to the cemento-enamel junction. Graft thickness, length and width are recorded for each treated site. The procedure was performed as routine clinical care and was not assigned for research purposes.
Preoperative intraoral photographs and baseline clinical variables are analysed by a deep learning model that predicts the outcome of root coverage surgery. The model output is not used in clinical decision making and does not influence treatment; it is compared retrospectively with the outcome measured by the treating periodontist at six months. The same photographs are also used to assign the recession type automatically, which is compared with the clinical assignment.
Accuracy of the model in predicting root coverage at six months
Difference between the root coverage predicted by a model based on preoperative intraoral photographs and baseline clinical characteristics, and the root coverage observed at six months. Root coverage is expressed as the percentage of the baseline recession depth that is covered, calculated as \[(baseline recession depth - six-month recession depth) / baseline recession depth\] × 100, from probing measurements made by the treating periodontist from the cemento-enamel junction to the gingival margin. Predictive accuracy is summarised as the mean absolute error in percentage points across all treated sites.
Time frame: 6 months
Sensitivity and specificity of the model at the selected decision threshold
Proportion of sites correctly identified by the model among those that achieved the outcome (sensitivity) and among those that did not (specificity), evaluated at the operating point selected on the receiver operating characteristic curve. Both proportions are reported with 95% confidence intervals. The reference standard is the clinical measurement made at six months by the treating periodontist, using a periodontal probe from the cemento-enamel junction to the gingival margin.
Time frame: 6 months
Calibration of the model
Agreement between the probability predicted by the model and the frequency observed in the cohort, assessed by the calibration slope and intercept and displayed as a calibration plot. Discrimination indicates whether the model ranks sites correctly; calibration indicates whether the predicted probabilities are numerically correct, and the two are reported separately because a model may rank well while producing miscalibrated probabilities. The reference standard is the clinical measurement made at six months.
Time frame: 6 months
Agreement between the model-assigned and the clinician-assigned recession type
Proportion of treated sites at which the recession type assigned by the model from the preoperative photograph matches the type assigned by the examining periodontist, reported together with quadratic weighted kappa. The reference standard is the clinical assignment recorded at baseline according to the criteria of Cairo et al.
Time frame: Baseline
Started Sep 2025 (actual). Primary completion is estimated for Sep 2026, 12 months after the start.
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