An interventional study of Coronally Advanced Flap with Connective Tissue Graft and Hyaluronic Acid/Polynucleotides in RT II Gingival Recession, sponsored by Cairo University. Not yet recruiting at 1 site in Egypt. Open to participants aged 15 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-08-21.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
Among 35 studies in Gingival Recession by Cairo University — 14 open to participants now, 14 under way, 2 of them phase 3. Gingival Recession · Cairo University.
Among the 35 studies in Gingival Recession by Cairo University, this one is the 33rd largest by planned enrollment, is one of 5 that started in 2026, is one of 30 with no phase, reaches primary completion later than 11 of the 13 other live ones, and was the 35th registered.
426 studies on the registry are indexed under Gingival Recession; 106 are open to participants now.
This study's planned enrollment of 12 is below the median of 30 across 390 interventional studies indexed under Gingival Recession.
Browse Gingival Recession studies →14 of the 35 studies in Gingival Recession by Cairo University are open now, in 1 country. Each count lists the studies.
Of the 64 Gingival Recession studies recruiting now, 30 (47%) set no upper age limit and 31 (48%) stop at 75 or younger; 1 take children under 18; 36 take healthy volunteers.
This study: 15 Years to 60 Years · all sexes · no healthy volunteers.
The full table on the hub →35 studies; the count open now beside each. This study's row is marked.
First in 2014; this study’s year is marked. 5 started in 2026.
Median enrollment 24 across the 35 interventional studies. Of the 8 that completed or were terminated, 1 (13%) have results posted.
Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
7 of the studies in Gingival Recession by Cairo University that are under way reach primary completion within a year, 2 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06643507Phase 3Cairo UniversityEvaluation of the Modified VISTA Technique Using ALB-PRF vs CTG in the Treatment of Multiple Miller Class III Recessions | 2026-12-20 |
| NCT07590375Phase 3Cairo UniversityTopical Phenytoin for Management of Gingival Recession | 2027-09-01 |
| NCT07520539Cairo UniversityAdding Effect of Cross-linked Hyaluronic Acid to Microneedling After Coronally Advanced Flap in Isolated RT1 Recession | 2026-12-01 |
| NCT07064603Cairo UniversityClinical Evaluation of (TCAF) Versus (CAF) Combined With Connective Tissue Graft in the Treatment of Multiple RT2 Gingival Recession Sites | 2026-12-01 |
| NCT07526259Cairo UniversityComparative Evaluation of Novel 3D Tunneling Technique Versus Modified Coronally Advanced Tunnel (MCAT) With Connective Tissue Graft in the Management of Multiple RT2 Gingival Recession | 2027-01-10 |
Among the 35 studies in Gingival Recession by Cairo University, from their registry updates:
This case series will evaluate the effectiveness of injectable hyaluronic acid combined with polynucleotides as an adjunct to coronally advanced flap and connective tissue graft in patients with RT II gingival recession. Twelve patients will be included and followed for 6 months. Clinical outcomes will include percentage of root coverage, clinical attachment level gain, gingival thickness, probing depth, width of keratinized tissue, post-operative pain, and patient aesthetic satisfaction.
Patients with RT II gingival recession will be treated using a coronally advanced flap combined with a de-epithelialized connective tissue graft. Approximately 1-2 mL of a hyaluronic acid and polynucleotide mixture will be applied to the graft before suturing. Patients will be followed for 6 months. Clinical measurements will include recession depth and width, percentage of root coverage, clinical attachment level, gingival thickness, probing depth, keratinized tissue width, post-operative pain, and patient esthetic satisfaction.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants with RT II gingival recession will receive coronally advanced flap surgery with a de-epithelialized connective tissue graft combined with hyaluronic acid and polynucleotides.
Procedure: Coronally Advanced Flap with Connective Tissue Graft and Hyaluronic Acid/Polynucleotides
A coronally advanced flap will be performed with a de-epithelialized connective tissue graft. Approximately 1-2 mL of a hyaluronic acid and polynucleotide mixture will be applied to the graft before suturing
Percentage of Root Coverage
Percentage of root coverage will be calculated using the following formula: (Initial Recession Depth - Post-Treatment Recession Depth) / Initial Recession Depth × 100.
Time frame: Baseline, 1 month, 3 months, and 6 months
Clinical Attachment Level (CAL) Gain
Clinical attachment level will be measured in millimetres using a UNC-15 periodontal probe
Time frame: Baseline, 3 months, and 6 months
Recession Depth
Gingival recession depth will be measured in millimeters using a UNC-15 periodontal probe
Time frame: Baseline, 3 months, and 6 months
Recession Width
Gingival recession width will be measured in millimeters using a UNC-15 periodontal probe.
Time frame: Baseline, 3 months, and 6 months
Gingival Thickness
Gingival thickness will be measured in millimeters using an endodontic file
Time frame: Baseline, 3 months, and 6 months
Probing Depth
Probing depth will be measured in millimeters using a UNC-15 periodontal probe.
Time frame: Baseline, 3 months, and 6 months
Width of Keratinized Tissue
Keratinized tissue width will be measured in millimeters using a UNC-15 periodontal probe
Time frame: Baseline, 3 months, and 6 months
Post-Operative Pain
Post-operative pain will be assessed using a Visual Analogue Scale (VAS) questionnaire, with scores ranging from 1 to 10
Time frame: 1 week post-surgery
Patient Esthetic Satisfaction
Patient esthetic satisfaction will be assessed using a Visual Analogue Scale (VAS) questionnaire, with scores ranging from 1 to 10
Time frame: 3 months and 6 months
Plan to share: No — Individual participant data will not be shared with other researchers in order to maintain participant confidentiality and data privacy. Access to the study data will be limited to the principal investigator and supervisors.
Start is estimated for Sep 2026; primary completion for Mar 2027, 6 months later.
Of 233 non-industry interventional studies with no phase under Gingival Recession, half reached primary completion within 19 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 30. This study's planned 6 months is below that.
Counting every sponsor, half of 235 studies reached it within 19 months; a quarter within 11 and three quarters within 30.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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