An observational study in Functional Dyspepsia, Gastritis and Gastritis Chronic, sponsored by Universiteit Antwerpen. Recruiting at 3 sites in Belgium. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-18.
Sponsored by Universiteit Antwerpen · Observational
The goal of this clinical trial is to discover the prevalence of NHPH bacteria (Non-Helicobacter pylori Helicobacter species) in patients with one of the following conditions:
Exclusion criteria:
75 studies on the registry are indexed under Gastritis, Atrophic; 37 are open to participants now.
This study's planned enrollment of 150 is below the median of 509 across 54 observational studies indexed under Gastritis, Atrophic.
Browse Gastritis, Atrophic studies →Universiteit Antwerpen is the lead sponsor of 135 studies on the registry; 32 are open to participants now.
Compared within Gastritis, Atrophic, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Gastritis. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Patients with (pre)malignant gastric lesions with one of the following conditions:
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.
Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.
Biopsy and archival tissue
A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.
Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Functional dyspepsia following the Rome IV criteria
Active chronic gastritis, non-H. pylori induced atrophic gastritis, intestinal metaplasia and non-H.pylori gastric dysplasia
Gastric cancer, including siewert type 2 and 3 esophagastric junction cancers
Patients undergoing bariatric surgery
What is the prevalence of NHPH in patients with (pre)malignant gastric lesions
Time frame: During the 1st (and only visit)
Impact of NHPH infection on the mucin gene expression
What is the impact of NHPH presence on the mucin gene expression in the gastric antrum and corpus in the three abovementioned patient groups? Therefore, differential expression of mRNA (isoform) expression of a mucin gene set will be performed by targeted long-read and bulk short-read sequencing allowing to identify all mucins that are expressed in the three target groups.
Time frame: During the 1st (and only visit)
Finding non-invasive testing of NHPH using saliva, feces, blood samples and breath samples
What is the diagnostic performance of non-invasive testing of NHPH using saliva samples, fecal samples, blood samples or breath samples to screen for volatile organic compounds (VOCs), compared to standard PCR testing on gastric biopsy? Buccal swabs contain saliva and buccal cells and will be collected to perform PCR assays combined with sequencing. Also, the molecular analysis of exhaled breath containing strain-specific VOCs will be performed using gas chromatography-quadrupole time of flight (GS-QTOF-MS) technology and Ion Mobility Spectrometry (IMS).
Time frame: During the 1st (and only visit)
Plan to share: Undecided
No publications or documents are linked to this record.
Started Feb 2025 (actual). Primary completion is estimated for Mar 2028, 37 months after the start.
How these figures are worked out, and which studies are left out of them.
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