An interventional study of Constraint-Induced Movement Therapy and Task-Oriented Training in Poststroke/CVA Hemiparesis, sponsored by Riphah International University. Active, not recruiting at 1 site in Pakistan. Open to participants aged 45 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-09-30.
Sponsored by Riphah International University · Not applicable, Interventional, and Treatment
This controlled clinical study investigates and compares the effectiveness of CIMT and TOT in improving hand function among post-stroke patients. A total of 48 participants from hospitals in Sialkot will be randomly divided into two groups and receive a 3-week intervention consisting of 15 sessions. Outcomes will be assessed using the 9-Hole Peg Test, Jebsen-Taylor Hand Function Test, and grip strength, and the data will be analyzed using SPSS-21 under a single-blinded design.
This randomized clinical trial will compare the effects of Constraint-Induced Movement Therapy (CIMT) and Task-Oriented Training (TOT) on hand function in post-stroke patients. The study will be conducted over 11 months at Allama Iqbal Memorial Teaching Hospital and Life Care Hospital, Sialkot, with 48 participants (24 per group) recruited through convenience sampling and randomly assigned to either intervention.
Eligible participants will be stroke patients aged 45-65 years in the subacute to chronic phase (>3 months), medically stable, cognitively intact, and with minimal voluntary hand movement, while those with severe neurological, cognitive, or musculoskeletal impairments will be excluded.
Group A will receive CIMT involving restriction of the unaffected limb and intensive task-specific training, while Group B will receive TOT based on functional, task-oriented activities with progressive difficulty. Both interventions will be delivered over 3 weeks (15 sessions).
Outcomes will be measured using the 9-Hole Peg Test, Jebsen-Taylor Hand Function Test, and grip strength assessment. A single-blinded design will be used with blinded outcome assessors, and data will be analyzed using SPSS-21 to compare the effectiveness of both interventions.
468 studies on the registry are indexed under Paresis; 117 are open to participants now.
This study's enrollment of 48 is above the median of 37 across 420 interventional studies indexed under Paresis.
Browse Paresis studies →Riphah International University is the lead sponsor of 2,193 studies on the registry; 650 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria: Participants will be included if they meet the following criteria:
Exclusion Criteria: Participants will be excluded if they have:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants in this group will receive Constraint-Induced Movement Therapy (CIMT) consisting of restraint of the unaffected upper limb combined with intensive task-specific training and repetitive functional exercises of the affected upper extremity for 3 weeks.
Behavioral: Constraint-Induced Movement Therapy
Participants will receive task-specific upper limb rehabilitation involving functional activities, bilateral tasks, object manipulation, and daily living task practice for 45-60 minutes per session, 5 days per week for 3 weeks.
Behavioral: Task-Oriented Training
Participants will undergo intensive upper limb rehabilitation involving shaping techniques, repetitive task practice, and restraint of the unaffected upper limb for 90% of waking hours, 5 days per week for 3 weeks. The therapy is delivered for 3 weeks (15 sessions; 5 sessions per week), with each session lasting approximately 60 minutes of structured rehabilitation training plus additional functional practice as prescribed. Activities are progressively graded and include fine motor tasks, object manipulation, and functional reaching and grasping exercises designed to promote neuroplasticity and motor recovery
Also known as: CIMT
Participants will receive task-specific upper limb rehabilitation involving functional activities, bilateral tasks, object manipulation, and daily living task practice for 45-60 minutes per session, 5 days per week for 3 weeks. Each session consists of a 45-60 minute structured rehabilitation program including warm-up (ROM and stretching), task-specific training (reaching, grasping, pegboard, coin and card tasks), and bilateral functional activities with progressive difficulty and a cool-down phase. The intervention is delivered at an intensity of 5 sessions per week for 3 weeks, totaling 15 sessions.
Also known as: TOT
Nine-Hole Peg Test (NHPT)
The Nine-Hole Peg Test (9HPT) is a standardized and reliable assessment used to evaluate fine motor dexterity and hand function in individuals with post-stroke impairments. The test requires the participant to place nine pegs into nine holes and then remove them as quickly as possible, with each hand assessed separately. Performance is measured by the time (in seconds) required to complete the task, with shorter completion times indicating better manual dexterity and hand function, while longer times reflect greater impairment.
Time frame: Baseline to 3 weeks
Jebsen-Taylor Hand Function Test (JHFT)
The Jebsen-Taylor Hand Function Test (JHFT) is a standardized assessment that takes approximately 15 to 45 minutes to administer and measures everyday fine and gross motor dexterity through seven timed tasks, such as writing, card turning, and object manipulation. Patients complete each task as quickly as possible with one hand at a time while the clinician records the completion time in seconds. Lower execution times indicate superior hand function, providing an efficient way to track pre- and post-treatment recovery or compare performance between limbs
Time frame: baseline to 3 weeks
Plan to share: No — nill
Started Jul 2025 (actual). Primary completion is estimated for Oct 2026, 15 months after the start.
Of 221 non-industry interventional studies with no phase under Paresis, half reached primary completion within 31 months of starting (the median), counting those still running; a quarter within 13 and three quarters within 55. This study's planned 15 months is below that.
Counting every sponsor, half of 239 studies reached it within 32 months; a quarter within 13 and three quarters within 55.
Since we started tracking on Sep 25, 2026, the dates moved once, on Sep 30, 2026: primary completion Jul 2026 → Oct 2026 and completion Aug 2026 → Oct 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is active, not recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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