ClinicalTrials.gg
RecruitingNCT07762664Updated Aug 20, 2026

Photon-Counting CT Versus Conventional CT for Carotid Plaque Assessment in Patients With Carotid Artery Stenosis

An observational study in Carotid Artery Stenosis, Carotid Atherosclerosis and Carotid Atherosclerotic Plaque, sponsored by Chinese PLA General Hospital. Recruiting at 1 site in China. Open to participants aged 10 Years to 90 Years. Per ClinicalTrials.gov, last updated 2026-08-20.

Sponsored by Chinese PLA General Hospital · Observational

From the registry’s dates

  • Started Jan 2026; still recruiting 10 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
100
Ages
10 Years to 90 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-13

Among 70 studies in Carotid Stenosis with a site in China — 32 open to participants now, 36 under way, 1 of them phase 3. Carotid Stenosis · China.

Planned enrollment
22nd of 34
100 · median 200
Started
2026
with 6 others
Observational
34 of 70
19 open now
Primary completion
2029-01
later than 30 of 35 live
Registered
67th of 70
by date

Among the 70 studies in Carotid Stenosis with a site in China, this one is the 22nd largest by planned enrollment of the 34 observational ones that give a count, is one of 7 that started in 2026, is one of 34 observational ones, reaches primary completion later than 30 of the 35 other live ones, and was the 67th registered.

Carotid Stenosis

364 studies on the registry are indexed under Carotid Stenosis; 85 are open to participants now.

Browse Carotid Stenosis studies →

Open to participants now

32 of the 70 studies in Carotid Stenosis with a site in China are open now. Recruiting first, the newest first:

26 more — sign in →

All 32 open studies →

A study can be open while its sites in China have not opened yet or have stopped. Only those recruiting at a site in China →

Who these studies take

Of the 60 Carotid Stenosis studies recruiting now, 38 (63%) set no upper age limit and none (0%) stop at 75 or younger; 4 take children under 18; 4 take healthy volunteers.

This study: 10 Years to 90 Years · all sexes.

The full table on the hub →

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Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 70 studies in Carotid Stenosis with a site in China, or all of them as a file.
02

Study summary

This prospective observational study aims to compare photon-counting detector computed tomography angiography (PCD-CTA) with conventional energy-integrating detector computed tomography angiography (EID-CTA) for the assessment of carotid atherosclerotic plaques in patients with carotid artery stenosis.

Read the detailed description

This prospective observational study aims to compare photon-counting detector computed tomography angiography (PCD-CTA) with conventional energy-integrating detector computed tomography angiography (EID-CTA) for the assessment of carotid atherosclerotic plaques in patients with carotid artery stenosis.

The study will evaluate differences between the two CT techniques in the visualization and quantitative characterization of carotid plaques, including plaque morphology, plaque burden, plaque components, calcification-related artifacts, and degree of carotid artery stenosis. Objective and subjective image quality will also be compared.

The study is intended to determine whether the improved spatial resolution and spectral imaging capabilities of photon-counting CT provide advantages over conventional CT for the characterization of carotid atherosclerotic disease.

03

Conditions studied

  • Carotid Artery Stenosis
  • Carotid Atherosclerosis
  • Carotid Atherosclerotic Plaque

Keywords

  • Photon-Counting CT
  • Carotid Artery Stenosis
  • Plaque Characterization
  • Carotid Plaque
04

Who can participate

Ages eligible
10 Years to 90 Years
Sexes eligible
All
Sampling method
Non-probability sample

Study population

The study population will consist of patients with carotid atherosclerotic stenosis referred for carotid CT angiography. Eligible participants will be prospectively enrolled before carotid artery intervention.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age 18 years or older.
  • Patients with carotid atherosclerotic plaque or carotid artery stenosis.
  • Patients scheduled to undergo carotid artery stenting.
  • Patients undergoing preprocedural carotid CTA examination.
  • Ability to provide written .

Exclusion criteria

Exclusion Criteria:

  • Known allergy to iodinated contrast material.
  • Severe renal insufficiency or other to contrast-enhanced CT.
  • Pregnancy or suspected pregnancy.
  • Severe motion or other artifacts resulting in nondiagnostic image quality.
  • Incomplete clinical or imaging data.
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
100 participants (estimated)
Patient registry
No

Groups and cohorts

  • Patients With Carotid Artery Stenosis

    Patients with carotid artery stenosis who undergo preprocedural carotid CT angiography will be prospectively enrolled. Carotid plaque characteristics and image quality will be evaluated and compared between photon-counting detector CT angiography and conventional energy-integrating detector CT angiography.

06

What researchers measure

Primary outcomes

  1. Carotid Plaque Visualization and Characterization on PCD-CTA Compared With Conventional EID-CTA

    Carotid atherosclerotic plaques will be independently evaluated on photon-counting detector CTA and conventional energy-integrating detector CTA.

    Time frame: 1-4 years

Secondary outcomes

  1. Contrast-to-noise ratio on PCD-CTA compared with conventional EID-CTA

    Contrast-to-noise ratio (CNR) will be quantitatively calculated from measurements obtained on PCD-CTA and conventional EID-CTA using a predefined measurement method. CNR values will be compared between the two CT techniques.

    Time frame: 1-4years

07

Study locations

1 of 1 sites recruiting
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Jan 2026 (actual). Primary completion is estimated for Jan 2029, 36 months after the start.

Of 79 non-industry observational studies under Carotid Stenosis, half reached primary completion within 50 months of starting (the median), counting those still running; a quarter within 26 and three quarters within 104. This study's planned 36 months is below that.

Counting every sponsor, half of 87 studies reached it within 50 months; a quarter within 30 and three quarters within 104.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 8, 2026
First posted
Aug 13, 2026
StartActual
Jan 7, 2026
Primary completionEst.
Jan 7, 2029
CompletionEst.
Jan 7, 2029
Last update
Aug 20, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 20, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07762664
Responsible party
Xin Lou (Chairman, Chinese PLA General Hospital) — Principal investigator
First posted
Aug 13, 2026
Start date
Jan 7, 2026
Primary completion
Jan 7, 2029 (estimated)
Completion
Jan 7, 2029 (estimated)
Last update
Aug 20, 2026

Study contacts

Jinhao Lyu, MD
Contact
330322990@qq.com
+8615903562929
Jinying He
Contact
1527012389@qq.com
Xin Lou
study chair · Chinese PLA General Hospital

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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