An interventional study of Diaphragmatic and Pursed-Lip Breathing Exercises in Heart Failure, Breathing Exercises and Dyspnea, sponsored by Istanbul University - Cerrahpasa. Active, not recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-07.
Sponsored by Istanbul University - Cerrahpasa · Not applicable, Interventional, and Supportive care
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Among 130 studies in Heart Failure with a site in Turkey — 27 open to participants now, 38 under way, 13 of them phase 3. Heart Failure · Turkey.
Among the 130 studies in Heart Failure with a site in Turkey, this one is the 43rd largest by enrollment of the 87 interventional ones that give a count, is one of 19 that started in 2025, is one of 41 with no phase, reaches primary completion later than 17 of the 37 other live ones, and was the 125th registered.
6,332 studies on the registry are indexed under Heart Failure; 1,392 are open to participants now.
Browse Heart Failure studies →27 of the 130 studies in Heart Failure with a site in Turkey are open now. Recruiting first, the newest first:
Dokuz Eylul University · Sites in Turkey
Ages 18+
AstraZeneca · Sites in Turkey, United States, Argentina and 29 more countries
Ages 18+
Istanbul University - Cerrahpasa · Sites in Turkey
Ages 40+
Bayer · Sites in Turkey, United States, Argentina and 20 more countries
Ages up to 18
Novo Nordisk A/S · Sites in Turkey, United States, Argentina and 24 more countries
Ages 18+
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 966 Heart Failure studies recruiting now, 689 (71%) set no upper age limit and 89 (9%) stop at 75 or younger; 63 take children under 18; 96 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
130 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 2 8 · Phase 3 36 · Phase 4 5
First in 2003; this study’s year is marked. 19 started in 2025.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 112 is above the median of 76 across 4,049 interventional studies indexed under Heart Failure.
Median enrollment 111 across the 87 interventional studies, 102 across the 43 observational. Of the 81 that completed or were terminated, 27 (33%) have results posted.
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48 of 130 have an industry lead sponsor. The 10 most frequent:
Istanbul University - Cerrahpasa is the lead sponsor of 701 studies on the registry; 211 are open to participants now.
Istanbul University - Cerrahpasa has 6 studies filed under Heart Failure — fewer than ten, so there is no comparison to draw.
9 of the studies in Heart Failure with a site in Turkey that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06307652Phase 3AstraZenecaStudy to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function | 2027-04-16 |
| NCT07752706Istanbul University - CerrahpasaBreathing Exercises for Dyspnea and Anxiety in Heart Failure | 2026-12-05 |
| NCT06707220Baskent UniversityThe Türkiye Heart Failure Registry | 2027-01 |
| NCT07420088Erol Olcok Corum Training and Research HospitalSeasonal Physical Activity in Patients With Heart Failure With Cardiac Implantable Electronic Devices | 2027-01-21 |
| NCT06747689Dokuz Eylul UniversityAssociation Between Sleep Quality and Self-Care in Heart Failure Patients | 2027-05-01 |
Add all 9 to your calendar (.ics) → With an account.
Among the 130 studies in Heart Failure with a site in Turkey, from their registry updates:
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Heart failure is a leading cause of emergency department admissions, with dyspnea and psychological distress being among the most common presenting symptoms. This randomized controlled trial aims to evaluate the effect of nurse-guided diaphragmatic breathing and pursed-lip breathing exercises on dyspnea and psychological distress in patients presenting to the emergency department with heart failure. A total of 112 eligible participants will be randomly assigned in a 1:1 ratio to either an intervention group receiving breathing exercises in addition to standard care or a control group receiving standard care alone. Dyspnea severity will be assessed using the Modified Borg Dyspnea Scale, and psychological distress will be assessed using the Distress Thermometer at predefined time points. The findings are expected to provide evidence for the effectiveness of a simple, low-cost, nurse-led non-pharmacological intervention in improving symptom management in patients with heart failure.
Heart failure is a major public health problem associated with frequent emergency department admissions due to symptoms such as dyspnea and anxiety. Dyspnea is one of the most distressing symptoms experienced by patients with heart failure and is often accompanied by increased anxiety, which may further worsen respiratory distress. Although pharmacological treatment remains the cornerstone of acute management, non-pharmacological interventions, including breathing exercises, may provide additional symptom relief.
The aim of this randomized controlled trial is to evaluate the effect of diaphragmatic breathing and pursed-lip breathing exercises on dyspnea and anxiety in patients presenting to the emergency department with heart failure.
A total of 112 eligible patients will be randomly assigned to either an intervention group or a control group. Participants in the intervention group will receive standard emergency department care in addition to nurse-guided diaphragmatic breathing and pursed-lip breathing exercises. The control group will receive standard emergency department care alone.
Clinical parameters, including pulse rate, blood pressure, respiratory rate, oxygen saturation, and distress level, will be assessed according to the study protocol. Dyspnea severity will be evaluated using the Modified Borg Dyspnea Scale, and anxiety-related distress will be assessed using the Distress Thermometer. Outcome measurements will be obtained at baseline and at predefined time points following the intervention.
The primary objective is to determine whether breathing exercises reduce dyspnea severity and anxiety compared with standard care. The findings of this study are expected to provide evidence regarding the effectiveness of a simple, low-cost, and nurse-led non-pharmacological intervention that may improve symptom management in patients with heart failure treated in emergency departments.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Applicants must be 18 years of age or older. Volunteer to participate in the study. Present to the emergency department of the hospital where the study is planned to be conducted.
Having been diagnosed with stage III-IV heart failure by a physician. Being able to understand and speak Turkish.
Exclusion Criteria:
Being under 18 years of age Not being a volunteer to participate in the study Using narcotic analgesics to a degree that affects understanding questions and communication, Having a diagnosis of serious mental illness Not having been diagnosed with stage III-IV heart failure by a physician
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Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The New York Heart Association’s four classes of how much heart failure limits physical activity.
Studies set their own limit — many outside heart failure leave out class III–IV, while heart failure studies may ask for a particular class. Check the class this study names.
NYHA class (heart failure)
The New York Heart Association’s four classes of how much heart failure limits physical activity.
Studies set their own limit — many outside heart failure leave out class III–IV, while heart failure studies may ask for a particular class. Check the class this study names.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
No Intervention
Behavioral: Diaphragmatic and Pursed-Lip Breathing Exercises
Other: Diaphragmatic and Pursed-Lip Breathing Exercises
Participants received standard emergency department care plus nurse-guided diaphragmatic breathing and pursed-lip breathing exercises. The intervention consisted of three cycles of breathing exercises with rest periods between cycles. Participants were observed and supported throughout the intervention.
Change in psychological distress measured by the Distress Thermometer
Psychological distress will be assessed using the Distress Thermometer
Time frame: Baseline (before intervention), and at 5, 10, 15, 30, 45, and 60 minutes after initiation of the intervention.
Change in dyspnea severity measured by the Modified Borg Dyspnea Scale
Dyspnea severity will be assessed using the Modified Borg Dyspnea Scale
Time frame: Baseline (before intervention), and at 5, 10, 15, 30, 45, and 60 minutes after initiation of the intervention.
Plan to share: Yes — Individual participant data will be available upon reasonable request from the corresponding author after publication of the study. Data will be shared in anonymized form.
No publications or documents are linked to this record.
Started Mar 2025 (actual). Primary completion is estimated for Dec 2026, 21 months after the start.
Of 1,118 non-industry interventional studies with no phase under Heart Failure, half reached primary completion within 29 months of starting (the median), counting those still running; a quarter within 16 and three quarters within 50. This study's planned 21 months is below that.
Counting every sponsor, half of 1,354 studies reached it within 31 months; a quarter within 16 and three quarters within 52.
How these figures are worked out, and which studies are left out of them.
This study is active, not recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Istanbul University - Cerrahpasa →