An observational study in Gestatiaonl Diabetes Mellitus, sponsored by Samsun University. Active, not recruiting at 1 site in Turkey (Türkiye). Open to female participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-06.
Sponsored by Samsun University · Observational
Among 52 studies in Diabetes, Gestational with a site in Turkey — 9 open to participants now, 12 under way, none of them phase 3. Diabetes, Gestational · Turkey.
Among the 52 studies in Diabetes, Gestational with a site in Turkey, this one is the 13th largest by planned enrollment of the 24 observational ones that give a count, is one of 3 that started in 2026, is one of 24 observational ones, reaches primary completion later than 8 of the 11 other live ones, and was the 50th registered.
877 studies on the registry are indexed under Diabetes, Gestational; 200 are open to participants now.
Browse Diabetes, Gestational studies →9 of the 52 studies in Diabetes, Gestational with a site in Turkey are open now. Recruiting first, the newest first:
Burak Deniz Aydoğdu · Sites in Turkey
Ages 18–50 · Women only
Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization · Sites in Turkey
Ages 18–50 · Women only · Healthy volunteers
Izmir Ataturk Training and Research Hospital · Sites in Turkey
Ages 18–45 · Women only · Healthy volunteers
Izmir Katip Celebi University · Sites in Turkey
Ages 18+ · Women only
Umraniye Education and Research Hospital · Sites in Turkey
Ages 18–39 · Women only
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 136 Diabetes, Gestational studies recruiting now, 62 (46%) set no upper age limit and 72 (53%) stop at 75 or younger; 13 take children under 18; 62 take healthy volunteers.
This study: 18 Years to 45 Years · female · healthy volunteers too.
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52 studies; the count open now beside each. This study's row is marked.
First in 2013; this study’s year is marked. 3 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 90 is below the median of 175 across 289 observational studies indexed under Diabetes, Gestational.
Median enrollment 85 across the 28 interventional studies, 100 across the 24 observational. Of the 37 that completed or were terminated, 2 (5%) have results posted.
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None of the 52 has an industry lead sponsor. The 10 most frequent:
Samsun University is the lead sponsor of 89 studies on the registry; 20 are open to participants now.
Samsun University has 2 studies filed under Diabetes, Gestational — fewer than ten, so there is no comparison to draw.
2 of the studies in Diabetes, Gestational with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07750431Samsun UniversityThe Role of Progesterone Membrane Receptors in the Development of Gestational Diabetes Mellitus | 2027-01-01 |
| NCT07067411Yeditepe UniversityGamified Education for Diabetes Self-Management in GDM | 2027-07-01 |
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Among the 52 studies in Diabetes, Gestational with a site in Turkey, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The aim of this study is to investigate the potential roles of PGRMC1, PGRMC2, and PAQR family membrane progesterone receptors in the pathophysiology of gestational diabetes mellitus by comparing their expression levels in placentas from pregnancies complicated by gestational diabetes mellitus with those from healthy pregnancies.
Gestational Diabetes Mellitus (GDM) is a medical condition characterized by glycemic intolerance that is detected at any time during pregnancy but was not present prior to it. It can lead to adverse health outcomes. Global data from 2021 indicate that 21.1 million live births involved women (aged 20-49) who experienced some form of diabetes during pregnancy (1). The fundamental mechanism underlying GDM pathophysiology is not yet fully understood; however, it generally results from pancreatic β-cell dysfunction arising from a state of chronic insulin resistance during pregnancy (2). Progesterone is a steroid that plays a central role in maintaining pregnancy; it suppresses uterine contractions and supports fetal immune tolerance (3). Progesterone exerts its effects not only through classical nuclear progesterone receptors but also via membrane-associated progesterone receptors (mPRs). These receptors include PGRMC1, PGRMC2, and the PAQR family (PAQR7, PAQR8, etc.) (4). Paula et al. demonstrated that the elimination of progesterone receptors in β-cells improved β-cell function and glucose tolerance in female mice during pregnancy and diet-induced insulin resistance (5). Furthermore, Picard et al. reported an improvement in glucose homeostasis-driven by β-cell proliferation-in progesterone receptor knockout mice (6). However, data regarding the expression levels of these receptors in the placentas of patients who develop gestational diabetes mellitus remain limited. In light of all this information, the scope of our study is to compare the expression levels of progesterone membrane receptors in placentas from pregnancies complicated by gestational diabetes mellitus and healthy pregnancies, and to determine the roles of these receptors in the pathophysiology of gestational diabetes mellitus.
Pregnant women aged 18-45 years delivering at Samsun City Hospital will be enrolled. The study population will consist of women with singleton pregnancies complicated by gestational diabetes mellitus and healthy pregnant women with appropriate fetal growth serving as the control group. Placental tissue samples will be collected immediately after delivery for molecular analysis.
Inclusion Criteria: Healthy women with singleton pregnancies 18-45 years pregnant gestational diabetes mellitus -
Exclusion Criteria: Multiple pregnancies pregnant women under the age of 18 or over the age of 45
-
Control Group
Gestational diabetes mellitusGroupPregnant women diagnosed with gestational diabetes who will undergo placental tissue collection at delivery for molecularanalysis. Healthy Control GroupHealthy pregnant women with normal oral glucose tolerence test result who will undergo placental tissue collection at delivery for molecular analysis.
1. Placental PGRMC1,PGRMC2 and PAQR mRNA expression levels
Relative placental mRNA expression levels of PGRMC1, PGRMC2 and PAQR family receptors measured by quantitative real-time polymerase chain reaction (qRT-PCR) in placental tissue collected immedia
Time frame: Delivery
Plan to share: Yes
Supporting information: Study protocol
Started Jan 2026 (actual). Primary completion is estimated for Jan 2027, 12 months after the start.
Of 142 non-industry observational studies under Diabetes, Gestational, half reached primary completion within 43 months of starting (the median), counting those still running; a quarter within 19 and three quarters within 70. This study's planned 12 months is below that.
Counting every sponsor, half of 144 studies reached it within 43 months; a quarter within 19 and three quarters within 70.
How these figures are worked out, and which studies are left out of them.
This study is active, not recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Samsun University