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Not yet recruitingNCT07916558Updated Nov 4, 2026

Impact of Parasternal and Rectointercostal Blocks on Extubation Time

An observational study in Postoperative Pain and Extubation Time, sponsored by Samsun University. Not yet recruiting at 1 site in Turkey (Türkiye). Per ClinicalTrials.gov, last updated 2026-11-04.

Sponsored by Samsun University · Observational

Updated Nov 4, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
40
Sex
All
01

Study summary

"Postoperative pain constitutes a major recovery challenge in patients undergoing open-heart surgery with median sternotomy and chest tube insertion (subxiphoid/intercostal). This study aimed to evaluate the effect of parasternal and rectointercostal block administration-performed to achieve pain control and reduce the postoperative analgesic burden-on patient postoperative recovery and extubation time."

Read the detailed description

"Median sternotomy performed in open-heart surgery causes severe anterior chest wall pain in the postoperative period. This pain leads to inadequate inspiration, suppression of the cough reflex, atelectasis, and increased pulmonary complications. On the other hand, traditionally used high-dose opioid-based analgesia regimens delay the extubation process by causing respiratory depression, nausea, sedation, and impaired intestinal motility.

In current cardiac anesthesia practice, the primary goal is to reduce opioid consumption through multimodal analgesia approaches, enable early extubation (fast-track cardiac anesthesia), and shorten the duration of intensive care unit stay.

Median sternotomy performed in open-heart surgery causes severe anterior chest wall pain in the postoperative period. This pain leads to inadequate inspiration, suppression of the cough reflex, atelectasis, and an increase in pulmonary complications. On the other hand, traditionally used high-dose opioid-based analgesia regimens delay the extubation process by causing respiratory depression, nausea, sedation, and gastrointestinal motility disorders.

In current cardiac anesthesia practice, the primary goal is to reduce opioid consumption through multimodal analgesia approaches, enable early extubation (fast-track cardiac anesthesia), and shorten the length of stay in the intensive care unit.

Parasternal block (parasternal intercostal block or pectoral/parasternal fascial plane blocks) targets the anterior cutaneous branches of T2-T6 spinal nerves, providing potent analgesia around the sternum and internal mammary area. Studies in the literature demonstrate that bilateral parasternal block performed under ultrasonography (USG) guidance significantly controls somatic pain related to sternotomy incision.

Rectointercostal fascial plane block blocks the anterior and lateral cutaneous branches of T6-T9 intercostal nerves. It provides somatic analgesia in the epigastric region, subxiphoid incision lines, and the lower border of the anterior abdominal/chest wall. It specifically blocks the sharp pain at the subxiphoid chest tube (drain) insertion sites-which are not covered by the parasternal block applied for median sternotomy in open-heart surgery-and the discomfort during tube removal.

Opioid Sparing and Pulmonary Functions: Randomized controlled trials have reported that blocks administered intraoperatively or at the end of surgery reduce total postoperative 24-hour opioid (fentanyl, morphine, tramadol) consumption by 30% to 50%. Decreased opioid requirement improves the recovery quality of patients by minimizing systemic side effects.

Extubation Time: Optimization of analgesia ensures the maintenance of patient chest wall compliance and tidal volume. Literature shows that patients receiving blocks reach weaning criteria faster once normothermia and hemodynamic stability are achieved, and their mean extubation times are significantly shorter compared to control groups.

Although prospective studies exist in the literature, retrospective cohort analyses investigating the impact of clinical routine practice on extubation times and reflecting real-world data are needed.

For this purpose, patients who underwent open-heart surgery in our clinic during a 2-year period (2024-2025) will be screened to investigate the effect of block applications on extubation times.

"Patients' age, sex, BMI, presence of comorbidities, ejection fraction, duration of surgery, cardiopulmonary bypass time, cross-clamp time, extubation time, administration of rescue analgesia, Visual Analog Scale (VAS) score at extubation, EuroSCORE II, and length of intensive care unit (ICU) stay will be recorded.

The primary endpoint was determined as meeting the weaning criteria and achieving successful extubation.

The secondary endpoint was determined as discharge from the intensive care unit

02

Conditions studied

  • Postoperative Pain
  • Extubation Time

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Keywords

  • open heart surgery
  • extubation time
  • thoracic nerve block
03

In context

Pain, Postoperative

5,259 studies on the registry are indexed under Pain, Postoperative; 1,163 are open to participants now.

This study's planned enrollment of 40 is below the median of 101 across 624 observational studies indexed under Pain, Postoperative.

Browse Pain, Postoperative studies →

Lead sponsor

Samsun University is the lead sponsor of 89 studies on the registry; 22 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

"Patients who underwent open-heart surgery in our clinic during the period of 2024-2025

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients undergoing elective CABG or valve surgery
  • Patients with median sternotomy and chest tube/drain placement
  • Patients with complete anesthesia and intensive care unit follow-up records

Exclusion criteria

Exclusion Criteria:

  • Patients undergoing emergency surgery or reoperation
  • Patients who could not be extubated for more than 24 hours
  • Patients with missing medical record or follow-up data
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
40 participants (estimated)
Patient registry
No

Groups and cohorts

  • NERVE BLOCK GROUP

    "Patients who underwent ultrasound-guided parasternal and rectointercostal block for postoperative analgesia.

  • Standard Analgesia Group

    "Patients followed up with routine postoperative analgesics without receiving any nerve block."

06

What researchers measure

Primary outcomes

  1. POSTOPERATİVE EXTUBATİON TİME

    The primary result measure is the extubation period recorded as the time from the patient's arrival at the intensive care unit to successful extubation.

    Time frame: Within the first 24-48 hours postoperatively

Secondary outcomes

  1. Visual Analog Scale (VAS) Pain Score at 30 Minutes Post-Extubation

    "Assessment of postoperative pain intensity using the Visual Analog Scale (ranging from 0 to 10) 30 minutes following tracheal extubation

    Time frame: postoperative 30th minute

  2. Visual Analog Scale (VAS) Pain Score at 2 Hours Post-Extubation

    Assessment of postoperative pain intensity using the Visual Analog Scale (ranging from 0 to 10) 2 hours following tracheal extubation.

    Time frame: postoperative 2nd hour

07

Study locations

1 site
08

References and documents

Publications

  • Kelava M, Alfirevic A, Bustamante S, Hargrave J, Marciniak D. Regional Anesthesia in Cardiac Surgery: An Overview of Fascial Plane Chest Wall Blocks. Anesth Analg. 2020 Jul;131(1):127-135. doi: 10.1213/ANE.0000000000004682. PubMed 32032103 ↗
  • Tulgar S, Ciftci B, Ahiskalioglu A, Bilal B, Alver S, Sakul BU, Ansen G, Pence KB, Alici HA. Recto-intercostal fascial plane block: Another novel fascial plane block. J Clin Anesth. 2023 Oct;89:111163. doi: 10.1016/j.jclinane.2023.111163. Epub 2023 Jun 7. No abstract available. PubMed 37295124 ↗
  • Pascarella G, Costa F, Nonnis G, Strumia A, Sarubbi D, Schiavoni L, Di Pumpo A, Mortini L, Grande S, Attanasio A, Gadotti G, De Cassai A, Mattei A, Nenna A, Chello M, Cataldo R, Agro FE, Carassiti M. Ultrasound Guided Parasternal Block for Perioperative Analgesia in Cardiac Surgery: A Prospective Study. J Clin Med. 2023 Mar 6;12(5):2060. doi: 10.3390/jcm12052060. PubMed 36902846 ↗
  • Huang Y, Hong M, Mao Q, Liang D, Liu G, Huang M, Zhong H, Lu Y, Zhong Y, Chen Y. Impact of liposomal bupivacaine parasternal block combined with rectus sheath block on postoperative pain in patients undergoing sternotomy for cardiac surgery: a randomized controlled trial. BMC Anesthesiol. 2026 Jun 17;26(1):533. doi: 10.1186/s12871-026-03903-y. PubMed 42304225 ↗

Individual participant data

Plan to share: Undecided

09

Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Nov 4, 2026
Show all 1 update
  1. Nov 4, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07916558
Lead sponsor
Samsun University
Responsible party
Gökçe Özgen (SPECİALİST PHYSİCİAN, Samsun University) — Principal investigator
First posted
Nov 4, 2026
Start date
Oct 26, 2026 (estimated)
Primary completion
Nov 2, 2026 (estimated)
Completion
Nov 10, 2026 (estimated)
Last update
Nov 4, 2026

Study contacts

GÖKÇE ÜLTAN ÖZGEN
Contact
gokceozgen55@gmail.com
05067750245

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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