An interventional study of Olive leaf extract and Placebo in Healthy Adult Participants, Exercise Training and Neuromuscular Adaptations, sponsored by University of Lausanne. Recruiting at 1 site in Switzerland. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-08.
Sponsored by University of Lausanne · Not applicable, Interventional, and Basic science
The goal of this study is to investigate the effect of combining olive leaf extract supplementation with endurance training (moderate intensity continuous training or sprint interval training). We hypothesize that OLE supplementation during training, as compared to training alone with placebo, will translate into better performance outcomes. More specifically, we hypothesize that the additional benefits of OLE supplementation on performance will be mediated by improved mitochondrial characteristics in skeletal muscle and increased neural activation.
Maximal exercise capacity (VO2peak) predicts cardiovascular risk and all-cause mortality. Regular moderate to vigorous physical activity, a key determinant of VO2peak, is essential for an optimal health status of the general population. Thus, strategies that accentuate the health benefits of exercise may have considerable therapeutic benefits. Skeletal muscle Ca2+ handling is a primary determinant of exercise capacity. The regulation of skeletal muscle contraction by Ca2+ is coupled to mitochondrial energy production through a mechanism involving transport across the inner mitochondrial membrane by the mitochondrial Ca2+ uniporter (MCU). Ca2+ entry in the mitochondrial matrix controls Ca2+ -sensitive enzymes, including pyruvate dehydrogenase (PDH) activity, a rate-limiting enzyme for glycolysis. Olive leaf extract (OLE) contains \~40% of the natural polyphenol oleuropein and is a potent activator of MCU in skeletal muscle with anti-inflammatory and antioxidant properties. The present study will be a double-blind, randomized, placebo-controlled, parallel study in healthy young individuals (18-45 years) consisting of a 3-week endurance training (either moderate intensity continuous training or sprint interval training) period combined with OLE or placebo intake. We will examine the impact of OLE supplementation on maximal exercise capacity, knee extensor neuromuscular function, muscular and blood adaptations. The results of this study will elucidate whether OLE supplementation improves fitness parameters and the molecular mechanisms regulating these adaptations.
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The model of sprint interval training (SIT) consists of four to six 30 s all-out cycling bouts on a cycle ergometer, with 4 min rests between tests. Three sessions will be performed per week for three weeks.
Dietary Supplement: Olive leaf extract · Dietary Supplement: Placebo
The moderate intensity continuous training (MICT) consists of 40 to 60 min cycling on a cycle ergometer at 50% of the maximal aerobic power output. Three sessions will be performed per week for three weeks.
Dietary Supplement: Olive leaf extract · Dietary Supplement: Placebo
A capsule containing 250 mg of an olive leaf extract preparation will be swallowed with a glass of water daily for 21 days.
A capsule containing 336 mg of cellulose microcrystalline will be swallowed with a glass of water daily for 21 days.
maximal aerobic power
maximal power (in watts) measured during a graded exercise to failure
Time frame: before and after the three-week training period
Maximal oxygen uptake
maximal oxygen uptake (ml/min/kg) measured during a graded exercise until failure
Time frame: before and after the three-week training period
Submaximal heart rate and power
heart rate and power measured during submaximal cycling exercise
Time frame: before and after the three-week training period
Knee extensor neuromuscular function
maximal voluntary contraction force and maximal voluntary activation level
Time frame: before and after the three-week training period
Plan to share: Undecided
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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