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Not yet recruitingNCT07717775Updated Jul 27, 2026

A Study of Compare the Pharmacokinetic, Pharmacodynamic and Safety/Tolerability Characteristics Following Multiple Oral Administration of AD-234, AD-2341, and AD-2342 in Healthy Adults

A Phase 1 interventional study of AD-234 and AD-2341 in Gastritis, sponsored by Addpharma Inc.. Not yet recruiting at 1 site in South Korea. Open to participants aged 19 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-27.

Sponsored by Addpharma Inc. (part of Yuhan Corporation) · Phase 1, Interventional, and Treatment

Phase
Phase 1
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
19 Years to 50 Years
Sex
All
01

Study summary

Primary endpoint of this study is to evaluate the pharmacokinetic and pharmacodynamic characteristics of AD-234, AD-2341, AD-2342 in healthy subjects.

Read the detailed description

The purpose of this study is to evaluate the pharmacokinetic and pharmacodynamic characteristics and safety profiles of AD-234 compared with AD-2341, AD-2342 in healthy subjects.

02

Conditions studied

  • Gastritis

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03

In context

Gastritis

135 studies on the registry are indexed under Gastritis; 23 are open to participants now.

This study's planned enrollment of 30 is below the median of 200 across 97 interventional studies indexed under Gastritis.

Browse Gastritis studies →

Lead sponsor

Addpharma Inc. is the lead sponsor of 58 studies on the registry; 25 are open to participants now.

First submitted after Addpharma Inc. became part of Yuhan Corporation.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
19 Years to 50 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Healthy adult volunteers aged 19 to 50 years, inclusive, at the time of screening

    • Body weight between 50.0 kg and 90.0 kg, inclusive, and (BMI) between 18.5 kg/m\^2 and 29.9 kg/m\^2, inclusive, at the time of screening (BMI = weight [kg] / height [m]\^2)
    • For female participants: not pregnant, not breastfeeding, or surgically sterile (e.g., bilateral tubal occlusion, hysterectomy, bilateral salpingectomy, bilateral oophorectomy)

Exclusion criteria

Exclusion Criteria:

  • Participation in another clinical study with an drug within the 6 months from scheduled first administration Other exclusions applied
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

BMI (body mass index)

Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.

What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.

Investigational drug or device

A drug or device being studied in a clinical trial.

It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.

05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
30 participants (estimated)

Study arms

  • Experimental
    Arm A(Vonoprazan, Fexuprazan, Vonoprazan)

    Participants receive AD-234 - AD-2341-AD-2342

    Drug: AD-234 · Drug: AD-2341 · Drug: AD-2342

  • Experimental
    Arm B(Vonoprazan, Vonoprazan, Fexuprazan)

    Participants receive AD-234 - AD-2342- AD-2341

    Drug: AD-234 · Drug: AD-2341 · Drug: AD-2342

  • Experimental
    Arm C(Fexuprazan, Vonoprazan, Vonoprazan)

    Participants receive AD-2341-AD-234-AD-2342

    Drug: AD-234 · Drug: AD-2341 · Drug: AD-2342

  • Experimental
    Arm D(Fexuprazan, Vonoprazan, Vonoprazan)

    Participants receive AD-2341-AD-2342-AD-234

    Drug: AD-234 · Drug: AD-2341 · Drug: AD-2342

  • Experimental
    Arm E(Vonoprazan, Vonoprazan, Fexuprazan)

    Participants receive AD-2342 -AD-234-AD-2341

    Drug: AD-234 · Drug: AD-2341 · Drug: AD-2342

  • Experimental
    Arm F(Vonoprazan, Fexuprazan, Vonoprazan)

    Participants receive AD-2342-AD-2341-AD-234

    Drug: AD-234 · Drug: AD-2341 · Drug: AD-2342

Interventions

  • DrugAD-234

    AD-234 tablet administered orally

  • DrugAD-2341

    AD-2341 tablet administered orally

  • DrugAD-2342

    AD-2342 tablet administered orally

06

What researchers measure

Primary outcomes

  1. Percent of Time With Gastric pH ≥4 During the 24-hour Interval After the 7th Dose

    Time frame: From pre-dose (0h) on Day 7 to 24 hours post-dose on Day 7 of each treatment period (Period 1: Day 7-Day 8; Period 2: Day 28-Day 29; Period 3: Day 49-Day 50)

07

Study locations

1 site
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 27, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07717775
Lead sponsor
Addpharma Inc.
Responsible party
Sponsor
First posted
Jul 21, 2026
Start date
Aug 2026 (estimated)
Primary completion
Nov 2026 (estimated)
Completion
Nov 2026 (estimated)
Last update
Jul 27, 2026

Study contacts

JaeHun Jung
Contact
jhjung@addpharma.co.kr
+82-31-891-5683

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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