An interventional study of Ketorolac Tromethamine 0.5%-Soaked Bandage Contact Lenses and Contact Bandage Lenses in Refraction Error and Photorefractive Keratectomy, sponsored by Madina Teaching Hospital Faisalabad. Not yet recruiting at 1 site in Pakistan. Open to participants aged 21 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-07-15.
Sponsored by Madina Teaching Hospital Faisalabad · Not applicable, Interventional, and Supportive care
Photorefractive keratectomy (PRK) is a well-established surface ablation procedure for the correction of refractive errors. Despite excellent visual and refractive outcomes, postoperative pain remains a significant concern, particularly during the first few days following surgery. This pain is primarily related to corneal epithelial removal, exposure of subepithelial nerve endings, and the subsequent inflammatory response. Effective pain management is therefore essential to enhance patient comfort, improve compliance with postoperative care, and increase overall surgical satisfaction. Therefore we will compare postoperative pain levels in patients undergoing PRK using ketorolac tromethamine 0.5%-soaked bandage contact lenses versus non-medicated bandage contact lenses.
420 studies on the registry are indexed under Refractive Errors; 59 are open to participants now.
This study's planned enrollment of 60 is below the median of 76 across 301 interventional studies indexed under Refractive Errors.
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Exclusion Criteria:
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An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Group A will receive ketorolac-soaked bandage contact lenses immediately after surgery. Postoperative pain will be assessed using Visual Analogue Scale at defined intervals. Epithelial healing will be monitored clinically until complete re-epithelialization. Any complications arising during postoperative period will be documented for each group.
Device: Ketorolac Tromethamine 0.5%-Soaked Bandage Contact Lenses
Group B will receive standard non-medicated bandage contact lenses. Postoperative pain will be assessed using Visual Analogue Scale at defined intervals. Epithelial healing will be monitored clinically until complete re-epithelialization. Any complications arising during postoperative period will be documented for each group.
Device: Contact Bandage Lenses
Soaking Bandage Contact Lenses in ketorolac prior to application may provide sustained drug release at the ocular surface, thereby enhancing postoperative pain control while reducing the need for repeated topical administration.Recent studies have suggested that ketorolac-soaked Bandage Contact Lenses may significantly reduce pain following Photorefractive Keratectomy without adversely affecting epithelial healing
Bandage contact lenses (BCLs) are routinely used after PRK to protect the corneal surface, reduce mechanical irritation from blinking, and promote epithelial healing
Postoperative Pain
Postoperative pain assessed using a standardized pain scoring system (e.g., Visual Analogue Scale) at 6, 24, 48, and 72 hours postoperatively.
Time frame: 72 hours
Epithelial Healing
Time for epithelial healing
Time frame: 72 hours
Plan to share: No
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