ClinicalTrials.gg
Not yet recruitingNCT07683663Updated Jul 6, 2026

QIPB vs SI-FICB for Postoperative Analgesia After Total Hip Arthroplasty

An interventional study of Supra-Inguinal Fascia Iliaca Compartment Block and Quadro-Iliac Plane Block in Hip Osteoarthritis, Total Hip Arthroplasty (THA) and Postoperative Pain, sponsored by Dokuz Eylul University. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-07-06.

Sponsored by Dokuz Eylul University · Not applicable, Interventional, and Other

Phase
Not applicable
Study type
Interventional
Enrollment
84
Allocation
Randomized
Ages
18 Years to 75 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 27 studies in Osteoarthritis, Hip with a site in Turkey — 5 open to participants now, 5 under way, none of them phase 3. Osteoarthritis, Hip · Turkey.

Planned enrollment
5th of 18
84 · median 60
Started
2026
with 2 others
No phase
18 of 27
4 open now
Registered
27th of 27
by date

Among the 27 studies in Osteoarthritis, Hip with a site in Turkey, this one is the 5th largest by planned enrollment of the 18 interventional ones, is one of 3 that started in 2026, is one of 18 with no phase, and was the 27th registered.

By phase

27 studies; the count open now beside each. This study's row is marked.

No phasethis study18 · 4 open
Observational9 · 1 open

By the year they started

First in 2014; this study’s year is marked. 3 started in 2026.

What they test

Size and results

Median enrollment 60 across the 18 interventional studies, 60 across the 9 observational. Of the 20 that completed or were terminated, 0 (0%) have results posted.

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02

Study summary

Total hip arthroplasty (THA) causes moderate-to-severe postoperative pain. The PROSPECT guideline recommends the supra-inguinal fascia iliaca compartment block (SI-FICB) for THA, whereas evidence for newer quadratus-lumborum-family blocks is limited. The quadro-iliac plane block (QIPB) is a recently described fascial plane block, and no study has compared QIPB with SI-FICB head-to-head in any surgical context. In this prospective, double-blind, patients undergoing elective THA who receive one of the two routinely used preoperative blocks (SI-FICB or QIPB, chosen by the attending anesthesiologist as part of routine care) are systematically observed and compared. The primary objective is to assess whether the postoperative analgesic efficacy of QIPB is non-inferior to SI-FICB, using the resting NRS pain score at 6 hours postoperatively as the primary endpoint (non-inferiority margin Δ = 1.3).

03

Conditions studied

  • Hip Osteoarthritis
  • Total Hip Arthroplasty (THA)
  • Postoperative Pain
  • Acute Pain

Keywords

  • regional anesthesia
  • quadro-iliac plane block
  • fascia iliaca block
  • opioid consumption
  • quality of recovery
04

Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adults aged 18-75 years
  • Scheduled for elective primary total hip arthroplasty
  • I-III
  • Able to understand and communicate in Turkish and complete assessment scales
  • Completed preoperative anesthesia evaluation and approved for surgery
  • Signed written

Exclusion criteria

Exclusion Criteria:

  • Known allergy/ to any local anesthetic, including bupivacaine
  • Coagulopathy or anticoagulant/antiplatelet therapy contraindicating block (per ASRA 2022)
  • Active infection or skin breakdown at the block site
  • Chronic opioid use (≥3 months daily) or history of opioid dependence
  • Morbid obesity ( > 40 kg/m²)
  • Cognitive impairment or communication difficulty precluding reliable NRS/QoR-15 assessment
  • Pregnancy or breastfeeding
  • Revision THA or emergency THA for fracture
  • Intraoperative complications requiring major protocol deviation (e.g., >1000 mL blood loss, cardiac arrest)
  • Technically failed block (no sensory change at any region on the T1 cold test)
Terms in these criteria, in plain language(4)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

ASA physical status

The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

BMI (body mass index)

Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.

What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.

05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
84 participants (estimated)

Study arms

  • Active comparator
    SI-FICB

    Patients receiving supra-inguinal fascia iliaca compartment block (single-shot, US-guided, 40 mL 0.25% bupivacaine, preoperative).

    Procedure: Supra-Inguinal Fascia Iliaca Compartment Block

  • Experimental
    QIPB

    Patients receiving quadro-iliac plane block (single-shot, US-guided, 40 mL 0.25% bupivacaine, preoperative).

    Procedure: Quadro-Iliac Plane Block

Interventions

  • ProcedureSupra-Inguinal Fascia Iliaca Compartment Block

    SIFICB is an ultrasound-guided fascial plane block performed via a supra-inguinal approach to the iliac fascia compartment, targeting the femoral nerve, lateral femoral cutaneous nerve, and obturator nerve. Single-shot, US-guided, 40 mL 0.25% bupivacaine, before GA induction.

  • ProcedureQuadro-Iliac Plane Block

    QIPB is a facial plane block performed under ultrasound guidance with local anesthetic in the interfascial plane between the erector spinae and the quadratus lumborum muscle, at the distal attachment site of the quadratus lumborum muscle on the iliac crest. Single-shot, US-guided, 40 mL 0.25% bupivacaine, before GA induction.

06

What researchers measure

Primary outcomes

  1. Pain intensity at rest at 6 hours postoperatively

    Numeric Rating Scale (NRS), 0 = no pain to 10 = worst imaginable pain, measured at rest by a blinded assessor. Non-inferiority margin Δ = 1.3 NRS points.

    Time frame: 6 hours after surgery

Secondary outcomes

  1. NRS pain at rest

    Time frame: 0, 2, 4, 6, 12, 24, 48 hours postoperatively

  2. NRS pain on movement (active hip flexion)

    Time frame: 0, 2, 4, 6, 12, 24, 48 hours postoperatively

  3. Cumulative opioid consumption

    Time frame: 24 hours and 48 hours

07

Study locations

1 site
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Start is estimated for Jun 2026; primary completion for Dec 2026, 5 months later.

Of 200 non-industry interventional studies with no phase under Osteoarthritis, Hip, half reached primary completion within 28 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 45. This study's planned 5 months is below that.

Counting every sponsor, half of 226 studies reached it within 29 months; a quarter within 14 and three quarters within 51.

How these figures are worked out, and which studies are left out of them.

Registered
Jun 23, 2026
First posted
Jul 6, 2026
StartEst.
Jun 30, 2026
Primary completionEst.
Dec 1, 2026
CompletionEst.
Jun 1, 2027
Last update
Jul 6, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jul 6, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07683663
Responsible party
Onur KUCUK (Associate Professor, Dokuz Eylul University) — Principal investigator
First posted
Jul 6, 2026
Start date
Jun 30, 2026 (estimated)
Primary completion
Dec 1, 2026 (estimated)
Completion
Jun 1, 2027 (estimated)
Last update
Jul 6, 2026

Study contacts

Onur Küçük, associate professor
Contact
onur.kucuk@deu.edu.tr
5358543333 ext. +90
Onur Küçük, associate professor
principal investigator · Dokuz Eylul University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

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