An observational study in Upper Gastrointestinal Bleeding and Acute Kidney Injury, sponsored by Sohag University. Not yet recruiting at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-09.
Sponsored by Sohag University · Observational
This study aims to evaluate the incidence of acute kidney injury (AKI) among patients presenting with acute upper gastrointestinal bleeding (UGIB) at Sohag University Hospitals, and to identify predictors associated with renal impairment in these patients.
Upper gastrointestinal bleeding (UGIB) is a common medical emergency associated with significant morbidity and mortality. Acute kidney injury (AKI) is frequently observed in these patients, mainly due to hypovolemia and renal hypoperfusion. Despite its clinical importance, data regarding AKI incidence and predictors in UGIB patients, particularly in Middle Eastern populations, remain limited.
This prospective observational study aims to assess renal function abnormalities and identify predictors of AKI in patients with UGIB, including both variceal and non-variceal causes. The study will also evaluate clinical outcomes such as mortality, hospital stay duration, and need for renal replacement therapy.
339 studies on the registry are indexed under Gastrointestinal Hemorrhage; 79 are open to participants now.
This study's planned enrollment of 200 is close to the median of 200 across 116 observational studies indexed under Gastrointestinal Hemorrhage.
Browse Gastrointestinal Hemorrhage studies →Sohag University is the lead sponsor of 1,183 studies on the registry; 612 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult patients presenting with acute upper gastrointestinal bleeding and admitted to Sohag University Hospitals, including both ward and ICU patients, who meet the eligibility criteria and have available renal function data.
Exclusion Criteria:
Adult patients (≥18 years) presenting with acute upper gastrointestinal bleeding (UGIB) and admitted to Sohag University Hospitals. Patients will be followed prospectively to assess the incidence of acute kidney injury (AKI) and its predictors.
Other: Observational assessment
No therapeutic intervention is applied. Patients are managed according to standard hospital care, and data are collected observationally.
Incidence of Acute Kidney Injury (AKI) According to KDIGO Criteria
The incidence of acute kidney injury (AKI) among patients presenting with acute upper gastrointestinal bleeding (UGIB), defined according to KDIGO criteria based on changes in serum creatinine and/or urine output during hospitalization.
Time frame: From hospital admission through hospital discharge, up to 30 days
Percentage of Patients Developing AKI According to Bleeding Etiology
Comparison of AKI incidence between variceal and non-variceal UGIB patients.
Time frame: Baseline (hospital admission) with AKI occurrence assessed through hospital discharge, up to 30 days
Change in Serum Creatinine Concentration
Serum creatinine concentration (mg/dL) measured at admission and during hospitalization to assess changes in renal function.
Time frame: Through hospital discharge, up to 30 days
Plan to share: Undecided — A decision regarding sharing individual participant data (IPD) has not yet been finalized. Any future data sharing will be considered in accordance with institutional policies and participant consent.
This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Sohag University