ClinicalTrials.gg
RecruitingNCT07624396METAPROFIL 1Updated Sep 25, 2026

Association Between Circulating BDNF Levels and Cardioembolic Strokes in Patients Treated for Ischemic Stroke

An observational study in Acute Ischemic Stroke, sponsored by Centre Hospitalier Universitaire Dijon. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-25.

Sponsored by Centre Hospitalier Universitaire Dijon · Observational

From the registry’s dates

  • Started Sep 2026; still recruiting 1 month later.
Updated Sep 25, 2026Now RecruitingSite recruiting status changed+3 moreGo to Updates ↓

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Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
150
Ages
18 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-13

Among 164 studies in Ischemic Stroke with a site in France — 56 open to participants now, 61 under way, 10 of them phase 3. Ischemic Stroke · France.

Planned enrollment
39th of 55
150 · median 250
Started
2026
with 8 others
Observational
55 of 164
20 open now
Primary completion
2031-09
later than 58 of 60 live
Registered
162nd of 164
by date
Lead sponsor
5 of 164
Centre Hospitalier Universitaire Dijon

Among the 164 studies in Ischemic Stroke with a site in France, this one is the 39th largest by planned enrollment of the 55 observational ones that give a count, is one of 9 that started in 2026, is one of 55 observational ones, reaches primary completion later than 58 of the 60 other live ones, and was the 162nd registered.

Ischemic Stroke

2,619 studies on the registry are indexed under Ischemic Stroke; 976 are open to participants now.

Browse Ischemic Stroke studies →

Open to participants now

56 of the 164 studies in Ischemic Stroke with a site in France are open now. Recruiting first, the newest first:

50 more — sign in →

All 56 open studies →

A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →

Who these studies take

Of the 661 Ischemic Stroke studies recruiting now, 396 (60%) set no upper age limit and 62 (9%) stop at 75 or younger; 26 take children under 18; 42 take healthy volunteers.

This study: 18 Years and older · all sexes · no healthy volunteers.

The full table on the hub →

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Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 164 studies in Ischemic Stroke with a site in France, or all of them as a file.
02

Study summary

Atrial fibrillation (AF) is associated with serious complications, including embolic strokes, heart failure, and mortality. Disruption of normal blood flow in the atrium, particularly in the context of an endocardium predisposed to thrombosis, increases the risk of thrombus formation. Once dislodged from the atrial cavity and traveling to the cerebral arteries, these thrombi can cause a cardioembolic stroke. The main risk factors for atrial cardiomyopathy (ACM) and AF are metabolic syndrome and aging.

ACM is a condition that is difficult to diagnose because it is not clearly defined, except through histological analysis. Guided by the results of our experimental approaches, the investigators aim to address this challenge by examining ACM through the lens of one of its complications: cardioembolic stroke. BDNF (Brain-Derived Neurotrophic Factor) is a neurotrophic factor involved in inflammatory and metabolic processes that may play a key role in the development of these complications.

This study explores the association between circulating levels of BDNF and the morphological and metabolic characteristics of ACM, as assessed by cardiac and brain imaging studies

03

Conditions studied

  • Acute Ischemic Stroke

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04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

A patient diagnosed with acute ischemic stroke, confirmed by brain imaging (CT or MRI).

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Individuals who provided
  • Diagnosis of acute ischemic stroke confirmed by brain imaging (CT or MRI)
  • Patient admitted to the USINV of the Department of General, Vascular, and Degenerative Neurology at the Dijon Bourgogne University Hospital during the inclusion period
  • Underwent a combined cardiac and brain CT scan within 24 hours of admission for stroke

Exclusion criteria

Exclusion Criteria:

  • A person subject to a legal protective measure (guardianship, conservatorship)
  • A person subject to a judicial safeguard measure
  • A pregnant woman, a woman who has recently given birth, or a breastfeeding woman
  • An adult who is legally incapacitated or unable to give consent,
  • A minor
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
150 participants (estimated)
Target follow-up
36 Months
Patient registry
Yes
Biospecimen retention
Samples without dna

Groups and cohorts

  • Patient who has suffered an acute ischemic stroke

    Patient diagnosed with acute ischemic stroke based on brain imaging

    Biological: Circulating BDNF levels measured via blood sample

Interventions

  • BiologicalCirculating BDNF levels measured via blood sample

    Diagnosis of cardioembolic stroke according to the TOAST13 classification, adjudicated with a blinded review of biomarker data by the treating of a neurologist upon the patient' s hospital discharge

06

What researchers measure

Primary outcomes

  1. Diagnosis of cardioembolic stroke according to the TOAST classification, adjudicated with a blinded review of biomarker data by the treating of a neurologist upon the patient' s hospital discharge.

    Time frame: At hospital discharge (approximately 5 to 10 day after admission)

07

Study locations

1 of 1 sites recruiting
08

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedDate before it movedWhere the date was before it movedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Sep 2026 (actual). Primary completion is estimated for Sep 2031, 60 months after the start.

Of 396 non-industry observational studies under Ischemic Stroke, half reached primary completion within 56 months of starting (the median), counting those still running; a quarter within 25 and three quarters within 140. This study's planned 60 months is close to that.

Counting every sponsor, half of 438 studies reached it within 53 months; a quarter within 24 and three quarters within 127.

Since we started tracking on Sep 25, 2026, the dates moved once, on Sep 25, 2026: start Jun 2026 → Sep 2026, primary completion Jun 2031 → Sep 2031 and completion Jun 2031 → Sep 2031.

Earlier changes are on the record history on ClinicalTrials.gov ↗

How these figures are worked out, and which studies are left out of them.

Registered
Apr 17, 2026
First posted
Jun 3, 2026
StartActual
Sep 23, 2026was Jun 2026
Primary completionEst.
Sep 2031was Jun 2031
CompletionEst.
Sep 2031was Jun 2031
Last update
Sep 25, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Status
Not yet recruiting→Recruiting
changed Sep 25, 2026
Sites
Chu Dijon Bourgogne is now Recruiting
Sep 25, 2026
Start date
Jun 2026→Sep 23, 2026 (actual)
Sep 25, 2026
Primary completion
Jun 2031→Sep 2031
Sep 25, 2026
Study completion
Jun 2031→Sep 2031
Sep 25, 2026
Show all 1 update
  1. Sep 25, 2026
    Not yet recruiting→Recruiting
    Chu Dijon Bourgogne is now Recruiting
    Start date Jun 2026→Sep 23, 2026 (now actual)
    Primary completion Jun 2031→Sep 2031
    Study completion Jun 2031→Sep 2031
    + 1 other change: verification date

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

09

Registry details

Key details

Study ID
NCT07624396
Responsible party
Sponsor
First posted
Jun 3, 2026
Start date
Sep 23, 2026
Primary completion
Sep 2031 (estimated)
Completion
Sep 2031 (estimated)
Last update
Sep 25, 2026

Study contacts

Charles GUENANCIA, Pr
Contact
charles.guenancia@chu-dijon.fr
03.80.29.56.23

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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