An interventional study of MANOEUVRE therapy in Psychosis, SCHIZOPHRENIA 1 (Disorder) and Schizophrenia and Related Disorders, sponsored by King's College London. Not yet recruiting at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-03.
Sponsored by King's College London · Not applicable, Interventional, and Treatment
Supporting people with psychosis to manage their emotions using virtual reality
Many people who have experienced psychosis feel overwhelmed by their emotions. Emotions get in the way of doing what matters to them. They want support to manage emotions differently. There is evidence that people with psychosis find talking therapies that teach skills for managing emotions helpful. People said it helped them to understand and manage their emotions. However, they also wanted more help to apply skills they learned to their lives.
It is hard to help people to use therapy skills in real-life situations. Therapists cannot be present when the skills are needed. One solution is to use virtual reality (VR) to bridge the gap between the clinic and real-life. VR involves using a headset to see and hear a very life-like computer-generated simulation of everyday life situations. People with psychosis find VR therapies engaging and helpful. It can feel safer to try things out in VR.
Guided by the feedback of people with psychosis, this research will evaluate a novel therapy to help people with psychosis manage their emotions. Face-to- face therapy will be combined with VR so that people can practice emotion regulation skills safely with "live" coaching from a therapist. This should support people to use these skills when they need them.
Fifteen people with psychosis will be offered the therapy. Everyone will be asked what they think of it and complete questionnaires before and after therapy to see what impact it had on their lives.
A lived experience advisory group will support all aspects of the research process.
Background Many people with psychosis report difficulties understanding and managing their emotions (emotion regulation difficulties), yet evidence-based interventions are lacking. Brief interventions that teach emotion regulation skills show promise but service users report wanting additional support to apply what they have learned in therapy to their lives.
Aim: To test the initial feasibility and acceptability of a VR-assisted therapy (called MANaging emOtions in Everyday life Using Virtual REality; MANOEUVRE) for emotion regulation difficulties in psychosis
Methods A mixed methods case series will be undertaken. The study will recruit people with psychosis from NHS community care teams (in England). Assessments will be at baseline, post therapy and 3-month follow up. Feasibility and acceptability of a future trial will be assessed based on uptake/ recruitment, data completeness and qualitative feedback. Feasibility and assessment of the therapy will be assessed based on adherence, acceptability (sessional feedback ratings, qualitative interview feedback, side effect and satisfaction ratings), safety (adverse effects), implementation resources and fidelity.
Participants will complete measures of emotion regulation difficulties, adaptive emotion regulation skill use, psychological distress, personal recovery goal achievement and quality of life. To assess feasibility, individual-level changes will be calculated using the reliable change index to assess whether changes are more likely to reflect measurement error or actual clinical change. Group-level changes will be assessed using means and standard deviations and effect sizes (Cohen's d) with confidence intervals . A post therapy semi-structured interview will explore participants' experience of receiving MANOEUVRE.
1,626 studies on the registry are indexed under Psychotic Disorders; 293 are open to participants now.
This study's planned enrollment of 15 is below the median of 70 across 1,333 interventional studies indexed under Psychotic Disorders.
Browse Psychotic Disorders studies →King's College London is the lead sponsor of 506 studies on the registry; 125 are open to participants now.
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Exclusion Criteria:
Other: MANOEUVRE therapy
Virtual reality assisted psychological therapy for emotion regulation difficulties
Difficulties in Emotion Regulation Scale 16 item version (DERS-16)
Self reported emotion regulation difficulties
Time frame: Pre therapy, immediately after therapy, 3 month follow up
DBT Ways of Coping Checklist - DBT Skills Subscale
Adaptive use of emotion regulation skills
Time frame: Pre therapy, immediately after therapy, follow up
Clinical Outcomes in Routine Evaluation-10 item version (CORE-10)
Psychological distress
Time frame: Pre therapy, immediately after therapy, 3 month follow up
Goal Attainment Scaling (GAS)
Personal recovery goal achievement
Time frame: Pre therapy, immediately after therapy, 3 month follow up
Recovering Quality of Life (ReQoL-10)
Quality of life
Time frame: Pre therapy, immediately after therapy, 3 month follow up
Plan to share: Yes — Individual participant data that underlie the results after deidentification
This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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King's College London