A Phase 3 interventional study of Orforglipron in Diabetes Mellitus, Type 2, Diabetes Melletus and Glucose Metabolism Disorders, sponsored by Eli Lilly and Company. Recruiting at 40 sites in 4 countries. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-09-22.
Sponsored by Eli Lilly and Company · Phase 3, Interventional, and Treatment
The purpose of this study is to test the efficacy and safety of orforglipron in participants with T2D (type 2 diabetes) who participate in fasting during Ramadan. For each participant, the study will last up to 48 weeks with a minimum of 7 in clinic visits and 4 virtual visits.
Exclusion Criteria:
Administered orally
Drug: Orforglipron
Administered orally
Also known as: LY3502970
Change from Baseline in Hemoglobin A1C (HbA1c)
Time frame: Baseline, up to 8 Weeks after Start of Ramadan
Percentage of Participants with an HbA1c of less than (<) 7 Percent (%) (53 millimeters per mole (mmol/mol))
Time frame: Baseline, Up to 8 Weeks after Start of Ramadan
Change From Baseline in Fasting Serum Glucose (FSG)
Time frame: Baseline, Up to 8 Weeks after Start of Ramadan
Percent Change from Baseline in Body Weight
Time frame: Baseline, Up to 8 Weeks after Start of Ramadan
Change in EuroQol 5-Dimension 5-Level (EQ-5D-5L) Index
Time frame: Baseline, Up to 8 Weeks after Start of Ramadan
Percent Change in HbA1c
Time frame: 4 Weeks Prior to Ramadan, Up to Week 8 after Start of Ramadan]
Percent Change in Body Weight
Time frame: 4 Weeks Prior to Ramadan, Up to Week 8 after Start of Ramadan]
Plan to share: Yes
Supporting information: Study protocol, Sap, Csr
No publications or documents are linked to this record.
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Eli Lilly and Company