An interventional study of Engagement Strategy 1 and Engagement Strategy 2 in Substance Use Disorder (SUD), sponsored by Stanford University. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-14.
Sponsored by Stanford University · Not applicable, Interventional, and Treatment
The goal of this study is a fractional factorial optimization trial to optimize engagement in a CRAFT program for family members with loved ones in outpatient treatment for a substance use disorder.
This study aims to identify family engagement strategies that are feasible, acceptable, and appropriate and effective in increasing family member initiation with CRAFT. Participants will complete an iterative, online process where they will evaluate and rank different engagement strategies to identify the most optimal in increasing engagement and then participate in an optimization trial to identify which strategies were most effective in increasing family member engagement.
Family members (FMs) of people with substance use disorder (SUD)-including biological, extended, or chosen family-face chronic stress and are at high risk for mental and physical health problems. The impact is worsened by stigma, guilt, shame, and self-blame that often accompany a loved one's substance use, leading to social isolation and uncertainty about how to support recovery. Although FMs are motivated to help with treatment navigation, many do not seek support for themselves. Programs like Community Reinforcement and Family Training (CRAFT) can support FMs and provide tools to improve their own lives while assisting their loved one's recovery. While CRAFT is well-established in community settings for increasing a family member's initiation into treatment, its applicability in clinical SUD settings is less clear. It remains unknown whether CRAFT can enhance patient treatment retention in clinical settings and whether FMs who might not seek care would participate.
To advance the science of engaging and supporting families impacted by SUD, investigators will (1) Conduct an iterative online process with FMs and clinic staff to identify potential family engagement strategies that community health centers (CHCs) can deliver that are effective, feasible, acceptable, and appropriate, and (2) Test those strategies using a fractional factorial trial.
FAMILY MEMBERS:
Inclusion Criteria:
PATIENTS:
Inclusion Criteria:
CLINIC PROVIDERS:
Inclusion Criteria:
Exclusion Criteria (ALL):
All 4 Engagement Strategies
Behavioral: Engagement Strategy 1 · Behavioral: Engagement Strategy 2 · Behavioral: Engagement Strategy 3 · Behavioral: Engagement Strategy 4
Strategies 1-3
Behavioral: Engagement Strategy 1 · Behavioral: Engagement Strategy 2 · Behavioral: Engagement Strategy 3
Strategies 1-2
Behavioral: Engagement Strategy 1 · Behavioral: Engagement Strategy 2
Strategies 2-4
Behavioral: Engagement Strategy 2 · Behavioral: Engagement Strategy 3 · Behavioral: Engagement Strategy 4
Strategies 3-4
Behavioral: Engagement Strategy 3 · Behavioral: Engagement Strategy 4
Strategies 1 \& 3
Behavioral: Engagement Strategy 1 · Behavioral: Engagement Strategy 3
Strategies 2 \& 4
Behavioral: Engagement Strategy 2 · Behavioral: Engagement Strategy 4
Strategies 1, 2 \& 4
Behavioral: Engagement Strategy 1 · Behavioral: Engagement Strategy 2 · Behavioral: Engagement Strategy 4
Strategies 2-3
Behavioral: Engagement Strategy 2 · Behavioral: Engagement Strategy 3
Strategies 1, 3 \& 4
Behavioral: Engagement Strategy 1 · Behavioral: Engagement Strategy 3 · Behavioral: Engagement Strategy 4
Strategy 1
Behavioral: Engagement Strategy 1
Strategy 2
Behavioral: Engagement Strategy 2
Strategy 3
Behavioral: Engagement Strategy 3
Strategy 4
Behavioral: Engagement Strategy 4
Strategy 1 \& 4
Behavioral: Engagement Strategy 1 · Behavioral: Engagement Strategy 4
No Strategies
Behavioral: Placebo
Engagement Strategy
Engagement Strategy
Engagement Strategy
Engagement Strategy
No engagement strategies
Attendance
Attend at least 1 eINSPIRE session
Time frame: 2 months after baseline
Feasibility of Engagement Strategies
Assessed via the Intervention Usability Scale, score of 70+ indicates feasibility
Time frame: 6 months from enrollment
Acceptability of Engagement Strategies
Assessed via the Acceptability of Intervention Measure; 70%+ agree/strongly agree indicates acceptability
Time frame: 6 months from enrollment
Appropriateness of Engagement Strategies
Assessed via the Intervention Appropriateness Measure; 70%+ agree/strongly agree indicates appropriateness
Time frame: 6 months from enrollment
Plan to share: Yes — Aggregate quantitative survey data from Aim 2 will still be provided. All data will be de-identified prior to receipt by the repository, but the information needed to generate a global unique identifier (GUID) for the NIMH Data Archive (NDA) will be collected for each subject. Participant-level data, survey instruments, and measurement descriptions will be deposited to NIMH Data Archive in accordance with the NIH Data Management and Sharing Policy effective January 24, 2023.
Supporting information: Study protocol, Sap, Icf, Analytic code
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Stanford University