An interventional study of BPTB ACL Reconstruction and Hamstring ACL Reconstruction in Anterior Cruciate Ligament Injury, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 35 Years. Per ClinicalTrials.gov, last updated 2026-05-07.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
This prospective randomized controlled study compares outcomes of ACL reconstruction using bone-patellar tendon-bone (BPTB) versus hamstring tendon (HT) autografts in professional athletes.
The primary outcome is isokinetic muscle strength assessment. Secondary outcomes include IKDC score, return to athletic activity, and complication rates. Patients are followed for five years.
This randomized controlled trial evaluates BPTB versus HT autografts in professional athletes undergoing ACL reconstruction. Patients with isolated ACL rupture were randomly assigned to either graft.
All procedures and rehabilitation protocols were standardized. The primary outcome was isokinetic assessment of quadriceps and hamstring strength using a dynamometer. Secondary outcomes included IKDC score, return to sport, and complications.
Patients were followed for five years to assess functional recovery and long-term outcomes.
512 studies on the registry are indexed under Anterior Cruciate Ligament Injuries; 164 are open to participants now.
This study's enrollment of 65 is above the median of 56 across 373 interventional studies indexed under Anterior Cruciate Ligament Injuries.
Browse Anterior Cruciate Ligament Injuries studies →Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.
Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants undergoing ACL reconstruction using bone-patellar tendon-bone (BPTB) autograft.
Procedure: BPTB ACL Reconstruction
Participants undergoing ACL reconstruction using hamstring tendon autograft (semitendinosus and gracilis).
Procedure: Hamstring ACL Reconstruction
Arthroscopic anterior cruciate ligament reconstruction using bone-patellar tendon-bone autograft with interference screw fixation.
Arthroscopic anterior cruciate ligament reconstruction using semitendinosus and gracilis tendon autograft with appropriate fixation technique.
Isokinetic Quadriceps and Hamstring Muscle Strength
Isokinetic dynamometric assessment of quadriceps and hamstring muscle strength expressed as peak torque percentage relative to the contralateral limb using a standardized testing protocol.
Time frame: 12 months postoperatively
International Knee Documentation Committee (IKDC) Score
Patient-reported functional outcome measured using the IKDC subjective knee evaluation form.
Time frame: 12 months postoperatively
Time to Return to Athletic Activity
Time required for patients to return to pre-injury level of athletic activity.
Time frame: Up to 12 months postoperatively
Postoperative Complications
Incidence of complications including infection, anterior knee pain, extension lag, stiffness, and graft re-rupture.
Time frame: Up to 60 months postoperatively
Knee function using KOOS score
Patient-reported outcomes assessed using the Knee Injury and Osteoarthritis Outcome Score (KOOS), including subscales: * Pain * Symptoms * Sport and Recreation * Quality of Life Scores reported on a 0-100 scale (higher scores indicate better function).
Time frame: 60 months postoperatively
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Cairo University