ClinicalTrials.gg
CompletedNCT07562295Updated Sep 2, 2026

Periodontal Health Among Cigarette, Electronic Cigarettes, and Narghile Smokers

An observational study in Smokers and Periodontal Status, sponsored by Al-Hawash Private University. Completed at 1 site in Syria. Open to participants aged 18 Years to 25 Years. Per ClinicalTrials.gov, last updated 2026-09-02.

Sponsored by Al-Hawash Private University · Observational

Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
90
Ages
18 Years to 25 Years
Sex
All
01

Study summary

This study compares the different effects of traditional cigarettes, e-cigarettes, and narghile on periodontal health among a sample of Al-Hawash Private University students. The main question it aims to answer is: Are there statistically significant differences in periodontal parameters among different types of smokers?

Read the detailed description

The emergence of e-cigarettes and the increasing popularity of hookah smoking, alongside traditional cigarette use, have created a complex health landscape, particularly regarding periodontal health. Despite growing global awareness of smoking-related dangers, particularly among young people due to marketing of "safer" alternatives, there is a lack of research directly comparing the effects of these three smoking methods on periodontal tissues.

While research extensively covers the impact of smoking on periodontal tissues, despite the individual studies on each type of smoking, no study has directly compared the effects of cigarettes, e-cigarettes, and hookah on periodontal health in the same population.

Aim: study and compare the different effects of traditional cigarettes, e-cigarettes, and narghile on periodontal health among a sample of students at Al-Hawash Private University.

02

Conditions studied

  • Smokers
  • Periodontal Status

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Keywords

  • Smoking
  • Cigarettes
  • Periodontal Health
  • Electronic Cigarettes
  • Narghile Smokers
03

In context

Smoking

1,509 studies on the registry are indexed under Smoking; 193 are open to participants now.

This study's enrollment of 90 is below the median of 150 across 301 observational studies indexed under Smoking.

Browse Smoking studies →

Lead sponsor

Al-Hawash Private University is the lead sponsor of 6 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 25 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Smoker students at Al-Hawash Private University

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Cigarette smokers: Individuals who have smoked five or more cigarettes per day for at least one year.
  • E-cigarette smokers: Individuals who have smoked e-cigarettes one or more times per day for at least one year.
  • narghile smokers: Individuals who have used a hookah one or more times per day for at least one year.

Exclusion criteria

Exclusion Criteria:

  • Non-smokers
  • Ages older than 25 years
  • Dual smokers: Individuals who smoke two or more types of tobacco.
  • Individuals with systemic diseases, such as diabetes, heart disease, liver problems, and kidney disease
  • Individuals who reported using antibiotics, , or NSAIDs within the past month
  • Individuals who have received periodontal treatment at least six months ago
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Corticosteroids (steroids)

Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.

Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.

05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
90 participants (actual)
Patient registry
No

Groups and cohorts

  • Cigarette Smokers

    Other: Non-Interventional Study

  • E-cigarette Smokers

    Other: Non-Interventional Study

  • Narghile Smokers

    Other: Non-Interventional Study

Interventions

  • OtherNon-Interventional Study

    Non-Interventional Study

06

What researchers measure

Primary outcomes

  1. Plaque Index (PI)

    Plaque Index (PI) The PI was evaluated according to the Silness and Löe (1964) system. This system assesses the plaque thickness at the tooth cervical margin (closest to the gum) and has four scores: 0: no plaque; 1. a film of plaque adhering to the free gingival margin which is nonvisible and it can be scraped from the tooth surface using a probe; 2. moderate accumulation of soft deposits within the gingival pocket or between the tooth and the gingival margin; 3. abundance of soft matter within the gingival pocket and/or on the tooth and the gingival margin. The presence of visible dental plaque was recorded on the four sites (vestibular, lingual, mesial, and distal) of all the teeth, except the third molars. three PI classes (PI%; \[0-1\[; \[1-2\[; \[2-3\]) were arbitrarily defined

    Time frame: At enrollment

  2. Gingival Index (GI)

    The gingival status was evaluated using the method of Löe and Silness (1963). The GI score perfectly evaluates the marginal and inter proximal tissues separately on the basis of the following three criteria (Löe \& Silness, 1963): 0: no inflammation, healthy gingiva; 1. mild inflammation, slight change in color, slight edema, no bleeding on pressure; 2. moderate inflammation, moderate glazing, red ness, bleeding on pressure; 3. severe inflammation, marked redness and hypertrophy, ulceration, tendency to spontaneous bleeding.

    Time frame: At enrollment

  3. Probing Pocket Depth (PPD)

    PPD is the distance between the gingival margin and the apical depth of the periodontal probe tip penetration. The depth of the sulci or pockets was probed using a Williams periodontal probe with markings 1, 2, 3, 5,7,8, 9, 10 mm. The clinical measurements were based on the four sites (buccal, mesial, distal, and lingual) of all the teeth, except the third molars (Natto et al., 2005b).

    Time frame: At enrollment

  4. Clinical Attachment Level (CAL)

    Clinical attachment level (CAL) is measured from the cementoenamel junction to the bottom of the sulcus or pocket at the four sites. The mean is then calculated for each patient.

    Time frame: At enrollment

  5. Bleeding On Probing (BOP)

    The bleeding on probing was assessed through gentle probing of the orifice of the gingival crevice .If bleeding occurs within 10 seconds, a positive finding was established and the number of positive sites was recorded and then expressed as the percentage of the number of sites examined.

    Time frame: At enrollment

  6. Tooth Mobility (TM)

    Tooth mobility, was performed by alternatively pressing on the tooth buccal and lingual surfaces using one finger and one metallic instrument Tooth mobility was recorded (Fleszar et al., 1980) as follows: 0: physiologic mobility, firm tooth; 1. slightly increased mobility; 2. definite to considerable increase in mobility but no function impairment; 3. extreme mobility, a loose tooth that would be incomparable in function

    Time frame: At enrollment

  7. Gingival Recession (GR)

    Gingival recession is measured by measuring the distance from the cementoenamel junction to the free gingival margin at the midpoint of the buccal surface.

    Time frame: At enrollment

  8. Furcation Involvement ( FI)

    Furcation involvement, is investigated clinically with a probe and classified according to the Hamp's classification system: Class 0 = no horizontal loss of periodontal tissue support (apart from the original scoring scale). Class I ≤3mm horizontal loss of periodontal tissue support. Class II \> 3 mm horizontal loss of periodontal tissue support, no through-and-through furcation Class III through-and-through furcation (required to see the tip of the probe at the contralateral furcation opening) and additionally

    Time frame: At enrollment

07

Study locations

1 site
  • Al-Hawash Private University
    Homs, Homs Governorate 0000, Syria
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jun 2025 to primary completion in Aug 2026, 14 months.

How these figures are worked out, and which studies are left out of them.

Registered
Apr 25, 2026
First posted
May 1, 2026
StartActual
Jun 1, 2025
Primary completionActual
Aug 31, 2026
CompletionActual
Aug 31, 2026
Last update
Sep 2, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Sep 2, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07562295
Lead sponsor
Al-Hawash Private University
Responsible party
Sponsor
First posted
May 1, 2026
Start date
Jun 1, 2025
Primary completion
Aug 31, 2026
Completion
Aug 31, 2026
Last update
Sep 2, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.

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