An observational study in Neurodevelopmental Disorders, sponsored by University Hospital, Tours. Recruiting at 1 site in France. Open to participants aged 6 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-16.
Sponsored by University Hospital, Tours · Observational
The goal of this observational study is to evaluate intra-individual neurophysiological variability in children and adults with and without NeuroDevelopmental Disorders (NDD), for several sensory modalities and types of stimulation. The main hypotheses are:
Participants in this study will:
These evaluations will be split in 3 visits spread on a maximum of 3 months, and training for learning will be done at home in between 2 visits.
Participants will be adults between 18 and 45 years old and children between 6 and 12 years old, with or without a Neurodevelopmental Disorder.
Inclusion Criteria:
Non-inclusion Criteria:
Exclusion Criteria:
6-12 years old children
18-45 years old adults
6-12 years old children
18-45 years old adults
Amplitude of central neurophysiological responses to sensory stimulations
Amplitude (in micro-volts) of event-related potentials
Time frame: Through study completion, an average of 2 months per participant
Latency of central neurophysiological responses to sensory stimulations
Latency (in milli-seconds) of event-related potentials
Time frame: Through study completion, an average of 2 months per participant
Variability of central neurophysiological responses to sensory stimulations
Intra-individual variability (in percentage) of event-related potentials
Time frame: Through study completion, an average of 2 months per participant
Visual perceptual learning performance
Discrimination performance (in percentage) for visual delayed-matching to sample task
Time frame: Through study completion, an average of 2 months per participant
Auditory perceptual learning performance
Discrimination performance (in percentage) for auditory delayed-matching to sample task
Time frame: Through study completion, an average of 2 months per participant
Behavioral sensory profile
Score (in absolute score) for psychomotor evaluation (Échelle des Particularités Sensori-psychomotrices dans l'Autisme)
Time frame: Through study completion, an average of 2 months per participant
Sensory profile questionnaire
Score (in absolute score) for sensory questionnaire (Dunn Sensory Profile)
Time frame: Through study completion, an average of 2 months per participant
Cognitive psychological profile
Score (in absolute score) for cognitive test (Raven's Progressive Matrices)
Time frame: Through study completion, an average of 2 months per participant
Executive functions questionnaire
Score (in absolute score) for executive functions questionnaire (BRIEF or BRIEF-A depending on the group)
Time frame: Through study completion, an average of 2 months per participant
Attentional functions questionnaire
Score (in absolute score) for attentional functions questionnaire (SNAP-IV-26 or ASRS-V1.1 depending on the group)
Time frame: Through study completion, an average of 2 months per participant
Socio-emotional questionnaire
Score (in absolute score) for socio-emotional questionnaire (AQ)
Time frame: Through study completion, an average of 2 months per participant
Linguistic profile
Score (in absolute score) for non-words and sentences repetition (LITMUS)
Time frame: Through study completion, an average of 2 months per participant
Heart beat response to sensory stimulations
Heart beat variation (in milliseconds) following sensory stimulation, recorded simultaneously with EEG
Time frame: Through study completion, an average of 2 months per participant
Electrodermal activity response to sensory stimulations
Electrodermal activity variation (in microsiemens) following sensory stimulation, recorded simultaneously with EEG
Time frame: Through study completion, an average of 2 months per participant
Pupillary response to sensory stimulations
Pupillary diameter variation (in millimeter) following sensory stimulation,recorded simultaneously with EEG
Time frame: Through study completion, an average of 2 months per participant
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University Hospital, Tours