ClinicalTrials.gg
RecruitingNCT06917209TCC-DISSOUpdated Jul 9, 2026

Evaluation of the Efficacy of Dissociation-Focused Cognitive Behavior Therapy

An interventional study of CBT-CD psychotherapy in Dissociative Disorder, sponsored by University Hospital, Tours. Recruiting at 8 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-09.

Sponsored by University Hospital, Tours · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started May 2025; still recruiting 1 year 5 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
140
Allocation
Randomized
Ages
18 Years and older
Sex
All
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Study summary

Dissociative symptoms and disorders are particularly prevalent in the general population and among people suffering from psychiatric disorders. To date, no treatment has proven effective for this type of problem. Exploratory studies (without control group) have been carried out. Among these studies, dissociation-focused cognitive behavioral therapy (DF-CBT) seems promising. DF-CBT is based on a solid empirical model that has received numerous scientific evidence.

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Conditions studied

  • Dissociative Disorder

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03

In context

Dissociative Disorders

41 studies on the registry are indexed under Dissociative Disorders; 13 are open to participants now.

This study's planned enrollment of 140 is above the median of 50 across 34 interventional studies indexed under Dissociative Disorders.

Browse Dissociative Disorders studies →

Lead sponsor

University Hospital, Tours is the lead sponsor of 307 studies on the registry; 79 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • ≥ 18 years
  • Membership of a social security scheme
  • Participant's express consent
  • Have at least one diagnosis of dissociative disorder among the following:

depersonalization/derealization disorder, dissociative identity disorder, unspecified dissociative disorder.

  • Be able to carry out psychotherapy sessions.
  • If taking psychiatric medication, treatment must have been stable for at least 30 days.

Exclusion criteria

Exclusion Criteria:

  • Present one of the following current diagnoses: substance use disorder (excluding tobacco), neurodevelopmental disorder, anorexia nervosa, severe depressive disorder, schizophrenia spectrum disorder, bipolar disorder, personality disorder other than borderline personality disorder.
  • Present cognitive deficits.
  • Be engaged in psychotherapeutic work.
  • Be undergoing benzodiazepine treatment.
  • Pregnant women and breastfeeding women
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
140 participants (estimated)

Study arms

  • Experimental
    The experimental group will receive 9 weekly sessions of DF-CBT psychotherapy.

    Other: CBT-CD psychotherapy

  • No intervention
    The control group will receive 9 weekly relaxation sessions.

Interventions

  • OtherCBT-CD psychotherapy

    9 weekly sessions of CBT-CD psychotherapy

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What researchers measure

Primary outcomes

  1. Difference in Dissociative Experience Scale (DES)

    Difference in Dissociative Experience Scale (DES) between randomization and 3 months after. The DES assesses dissociation through 28 items. The total score ranges between 0 and 100, where high scores indicate high levels of dissociation.

    Time frame: Between randomization and 3 months after

Secondary outcomes

  1. Hetero-administered visual analogue scale

    Visual analogue scales in which the practitioner rates the intensity of the patient's dissociative symptoms on the basis of his/her clinical assessment.

    Time frame: At randomization, 3 months and 6 months after

  2. Dissociation Questionnaire (DIS-Q)

    The Dissociation Questionnaire is a 63-item questionnaire measuring dissociative-trait manifestations. Participants respond to each item using a 5-point Likert scale. Four sub-scores (loss of control, absorption, amnesia and identity confusion) are calculated.

    Time frame: At randomisation, 3 months and 6 months after

  3. Hospital Anxiety Depression Scale (HADS)

    Hospital Anxiety Depression Scale (HADS) is a 14-item self-report questionnaire. Two sub-scores (anxiety and depression) are calculating. Both scores range between 0 and 21 with 0 corresponding to the ideal score (no anxiety or depression symptoms).

    Time frame: Randomization, 3 months and 6 months after

  4. Post traumatic stress disorder checklist scale (PCL-5)

    The post traumatic stress disorder checklist scale (PLC-5) is 20-item scale to assess post-traumatic stress symptoms. Participants respond to each item using a 5-point Likert scale. The score ranges between 0 and 80, with 0 reflecting no post traumatic stress disorder.

    Time frame: Randomization, 3 months and 6 months after

  5. Satisfaction With Life Scale (SWLS)

    The Satisfaction With Life Scale (SWLS) is a 5-item questionnaire assessing quality of life. Participants respond to each item using a 7-point Likert scale. The score range bewteen 0 and 35 with 35 reflects an extreme satisfaction with life.

    Time frame: Randomization, 3 months and 6 months after

  6. Dissociative Experiences Scale (DES)

    The DES assesses dissociation through 28 items. The total score ranges between 0 and 100, where high scores indicate high levels of dissociation.

    Time frame: At 6 months after randomization

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Study locations

2 of 8 sites recruiting
  • Psychiatrie / CHU ANGERS
    Angers, France
    Not yet recruiting
    • François KAZOUR, MD-PhD · Contact
    • François KAZOUR, MD-PhD · Principal investigator
  • Centre régional du Psychotraumatisme des Hauts de France / CHU LILLE
    Lille, France
    Not yet recruiting
    • Arnaud LEROY, MD-PhD · Contact
    • Arnaud LEROY, MD-PhD · Principal investigator
  • Urgences psychiatrique / CHU MONTPELLIER
    Montpellier, France
    Not yet recruiting
    • Matthieu FRAIGNEAU, MD · Contact
    • Matthieu FRAIGNEAU, MD · Principal investigator
  • Unité de neuromodulation en psychiatrie / CHU NANTES
    Nantes, France
    Not yet recruiting
    • Anne SAUVAGET, MD-PhD · Contact
    • Anne SAUVAGET, MD--PhD · Principal investigator
  • Centre départemental de Psychotraumatologie (unité TCC) / ORLEANS
    Orléans, France
    Not yet recruiting
    • Sophie LAPUJOULADE, MD · Contact
    • Sophie LAPUJOULADE, MD · Principal investigator
  • Centre Régional du Psychotraumatisme du Grand Est / CHU STRASBOURG
    Strasbourg, France
    Not yet recruiting
    • Arnaury MENGIN, MD · Contact
    • Arnaury MENGIN, MD · Principal investigator
  • Centre Régional du Psychotraumatisme CRP / CHRU TOURS
    Tours, France
    Recruiting
    • Lyna CHAMY, MD · Contact
    • Lyna CHAMY, MD · Principal investigator
  • Unité de Neuromodulation / CHU de Tours
    Tours, France
    Recruiting
    • Wissam EL HAGE, MD-PhD · Contact
    • Wissam EL HAGE, MD · Principal investigator
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Started May 2025 (actual). Primary completion is estimated for Nov 2028, 42 months after the start.

How these figures are worked out, and which studies are left out of them.

Registered
Apr 1, 2025
First posted
Apr 8, 2025
StartActual
May 16, 2025
Primary completionEst.
Nov 16, 2028
CompletionEst.
May 16, 2029
Last update
Jul 9, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jul 9, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06917209
Responsible party
Sponsor
First posted
Apr 8, 2025
Start date
May 16, 2025
Primary completion
Nov 16, 2028 (estimated)
Completion
May 16, 2029 (estimated)
Last update
Jul 9, 2026

Study contacts

Alexis VANCAPPEL, PhD
Contact
alexis.vancappel@univ-tours.fr
02.34.37.89.47
Alexis VANCAPPEL, PhD
study chair · Unité de Neuromodulation / CHU de Tours
Wissam EL HAGE, MD-PhD
principal investigator · Unité de Neuromodulation / CHU de Tours

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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