An observational study in Host and Microbiome, Pregnancy Outcomes and Pregnancy Complications, sponsored by Guangzhou Women and Children's Medical Center. Recruiting at 1 site in China. Per ClinicalTrials.gov, last updated 2026-09-16.
Sponsored by Guangzhou Women and Children's Medical Center · Observational
The long-term goal of the Human Genes and Microbiota in Early Life (HuGME) is to explore the short- and long-term effects of maternal microbiota during pregnancy and the microbiota colonization of their offspring early in life and their interaction with the host on maternal-offspring health consequences in later life in the born in Guangzhou cohort study in China. Identification of the effect of microbiota in early life, as well as environmental factors and microbe-host interaction, will lead to a better understanding of disease pathogenesis and provide a foundation for targeted mechanistic investigation into the consequences of microbial-host crosstalk for long-term health. It also can result in new strategies to predict and prevent diseases in later life.
Prenatal and early postnatal life represent critical windows for growth and cognitive and immune system development. In addition to genetics and host biology, the environment plays a critical role in the health of a child. One key player in this process is the maternal and infant gut microbiomes. The establishment and progression of the intestinal microbiota from birth to childhood are dependent on a range of factors, including maternal microbiota, diet, environment, and medical exposures. The host-microbial crosstalk during this time is thought to be involved in the pathobiology of later-life diseases, such as allergic disease, obesity, and neurodevelopmental delay. Although the microbiome and its importance for health have been extensively studied, it remains unclear how maternal microbiota-fetal interaction, the establishment, and progression of microbiota in infant adaptation to postnatal environmental exposures, and microbial-host crosstalk affect the health of the children in later life.
Hypotheses:
411 studies on the registry are indexed under Pregnancy Complications; 113 are open to participants now.
This study's planned enrollment of 20,000 is above the median of 400 across 198 observational studies indexed under Pregnancy Complications.
Browse Pregnancy Complications studies →Guangzhou Women and Children's Medical Center is the lead sponsor of 58 studies on the registry; 30 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Pregnant women attending their first routine antenatal examinations (usually around week 16) and their partners and offsrping
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Pregnant women with \< 20 weeks of gestation Pregnant women intended to eventually deliver in Guangzhou Women and Children's medical center Permanent residengts of families intended to remain in Guangzhou with their child for ≥3 years
Exclusion Criteria:
Refuses to have blood and stool samples stored at Born in Guangzhou cohort study Biobank.
No treatment
Other: No intervention
No intervention
Numbers of participants with Childhood diseases. Including:
Obesity，asthma，allergic diseases，Delayed neural development，type 1 diabetes，maturity-onset diabetes of the young（MODY), hypertension
Time frame: 42 days, 6 months, 1, 3, 6, 8-9, 14, and18 years of age
Numbers of participants with maternal diseases. Including:
Obesity，asthma，allergic diseases，type 1 diabetes，type 2 diabetes, hypertension , cardiovascular diseases，and obstetric complications，including gestational diabetes，pregnancy induced hypertension, ect.
Time frame: during pregnancy, 42 days, 6 months, 1, 3, 6, 8-9, 14, and18 years after delivery
Neurodevelopment during early childhood
Including adaptive, gross motor, fine motor,language,and social function; assessed using Gesell Developmental Schedules
Time frame: at age of 3 years
Neurodevelopment during early childhood
Including adaptive, gross motor, fine motor,language,and social function; assessed using Ages and Stages Questionnaire
Time frame: at age of 3 years
Neurodevelopment during preschool age
Including solving skills, pattern perception, and logical thinking；assessed using Raven's Standard Progressive Matrices
Time frame: at age of 6 years
Neurodevelopment during preschool age
Including solving skills, pattern perception, and logical thinking；assessed using Peabody Picture Vocabulary Test
Time frame: at age of 6 years
Neurodevelopment during preadolescence
Including higher-level cognitive processes such as attention, perseverance, WM, abstract thinking, CF, and set shifting;assessed using Raven's Standard Progressive Matrices
Time frame: at age of 8-9 years
Neurodevelopment during preadolescence
Including higher-level cognitive processes such as attention, perseverance, WM, abstract thinking, CF, and set shifting;assessed using Wsiconsin card sorting test
Time frame: at age of 8-9 years
maternal and childhood abnormal glucose metabolism after delivery
blood glucose level：glycosylated hemoglobin，fasting blood glucose, 1-hour glucose, 2-hour glucose, ect.
Time frame: 3, 6 and 9 years after delivery
maternal and childhood abnormal lipid metabolism after delivery
Lipid level : total cholesterol, triglycerides, LDL, HDL, etc.
Time frame: 3, 6 and 9 years after delivery
Plan to share: No
Started Apr 2019 (actual). Primary completion is estimated for Dec 2038, 236 months after the start.
Of 113 non-industry observational studies under Pregnancy Complications, half reached primary completion within 60 months of starting (the median), counting those still running; a quarter within 30 and three quarters within 201. This study's planned 236 months is above that.
Counting every sponsor, half of 121 studies reached it within 60 months; a quarter within 30 and three quarters within 151.
How these figures are worked out, and which studies are left out of them.
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Guangzhou Women and Children's Medical Center