An observational study in Cardiac Arrest (CA), Extracorporeal Cardiopulmonary Resuscitation and Acute Brain Injury, sponsored by Capital Medical University. Completed at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-04-13.
Sponsored by Capital Medical University · Observational
Timely identification of acute brain injury (ABI) patterns in patients with extracorporeal cardiopulmonary resuscitation (ECPR) is essential for prognostic assessment and optimization of clinical management, particularly anticoagulation strategies. This study aimed to evaluate the safety and feasibility of early 0.23-T MRI examination in ECPR patients. The investigators further assessed the image quality of the 0.23-T MRI and investigated the incidence and patterns of ABI, as well as their associations with neurological outcomes. This prospective observational study was conducted in the emergency intensive care unit (EICU) of Beijing Chaoyang Hospital, a high-volume ECPR center. The primary outcome was the feasibility of performing 0.23-T MRI in patients undergoing ECPR, defined as successful completion of the examination without serious adverse events (AEs).
966 studies on the registry are indexed under Heart Arrest; 227 are open to participants now.
This study's enrollment of 36 is below the median of 200 across 383 observational studies indexed under Heart Arrest.
Browse Heart Arrest studies →Capital Medical University is the lead sponsor of 283 studies on the registry; 92 are open to participants now.
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Enrolled patients were those with out-of-hospital cardiac arrest of presumed cardiac cause, supported by ECPR, who achieved ROSC but remained unconscious and unable to obey verbal commands.
Exclusion Criteria:
Feasibility of 0.23-T MRI examination
Defined as the percentage of participants who successfully complete the MRI examination without experiencing serious adverse events (AEs). AEs include a decrease in ECMO flow \> 10%, a change in mean arterial pressure of ± 20%, or a change in minute ventilation \> 20%.
Time frame: From the initiation of the MRI scan until 6 hours after its completion.
Image Quality
Assessment of the diagnostic quality of 0.23-T MRI images by board-certified neuroradiologists to evaluate noise, artifacts, and anatomical clarity.
Time frame: Within 6 hours after the completion of the MRI scan.
Incidence of Acute Brain Injury (ABI)
The proportion of patients identified with ABI patterns (such as ischemic stroke, intracranial hemorrhage, or cerebral edema) based on 0.23-T MRI findings.
Time frame: From the onset of cardiac arrest to the completion of the MRI scan
The association between ABI and neurological outcomes
Neurological outcomes were assessed at 3 months after ROSC using the Glasgow-Pittsburgh Cerebral Performance Category (CPC) scale. The CPC scale ranges from 1 to 5, with 1 indicating good performance, 2 indicating moderate disability, 3 indicating severe disability, 4 indicating vegetative state and 5 indicating brain death or death. The neurological outcomes were categorized as favorable prognosis (CPC 1-2) and poor prognosis (CPC 3-5).
Time frame: 3 months after ROSC.
Plan to share: No — Data supporting the findings of this study could be obtained from the corresponding author upon reasonable request.
This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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