An interventional study of Corneal Refractive Surgery in Corneal Wavefront Aberration and Refractive Errors, sponsored by Tianjin Eye Hospital. Not yet recruiting. Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-04-08.
Sponsored by Tianjin Eye Hospital · Not applicable, Interventional, and Prevention
To assess subjective visual symptoms using the QoV questionnaire, measure pupil size using the Atongmu Pupillometer, measure wavefront aberrations using the OPD-Scan III Aberrometer, and measure/calculate the effective optical zone using the Pentacam system. The relationships between pupil size, higher-order aberrations (HOAs), effective optical zone after refractive surgery, and subjective visual symptoms will be explored.
The sample size will be calculated using an appropriate sample size calculation formula. Using a random number table method, 1200 subjects scheduled for preoperative examination at the Refractive Surgery Center of Tianjin Eye Hospital between December 1, 2025, and May 1, 2026, will be randomly selected. Data including age, gender, spectacle wear status, uncorrected visual acuity (UCVA), spherical power, cylindrical power, intraocular pressure (IOP), mean keratometry (Km), corneal thickness, axial length, and degree of lens and vitreous opacities will be recorded. Pupil size under photopic, mesopic, and scotopic conditions will be measured using the Atongmu Pupillometer. Wavefront aberrations will be measured using the OPD-Scan III Aberrometer (OPD: Optical Path Difference). Subjects will complete the Quality of Vision (QoV) questionnaire.
Additionally, based on sample size calculation, using a random number table method, 300 subjects undergoing refractive surgery at the Refractive Surgery Center of Tianjin Eye Hospital between December 1, 2025, and May 1, 2026, will be randomly selected and prospectively followed up until 3 months postoperatively. Pupil size under photopic, mesopic, and scotopic conditions will be measured using the Atongmu Pupillometer. Wavefront aberrations will be measured using the OPD-Scan III Aberrometer before and after surgery. The effective optical zone (EOZ) will be measured and calculated using the Pentacam three-dimensional anterior segment analysis system. The QoV questionnaire will be administered postoperatively. Data will be collated and analyzed using statistical methods.
420 studies on the registry are indexed under Refractive Errors; 59 are open to participants now.
This study's planned enrollment of 300 is above the median of 76 across 301 interventional studies indexed under Refractive Errors.
Browse Refractive Errors studies →Tianjin Eye Hospital is the lead sponsor of 53 studies on the registry; 18 are open to participants now.
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Exclusion Criteria:
Corneal refractive surgery aims to correct refractive errors by altering the shape of the anterior surface of the cornea or by changing its refractive properties.
Procedure: Corneal Refractive Surgery
Corneal refractive surgery aims to correct refractive errors by altering the shape of the anterior surface of the cornea or by changing its refractive properties.
Total Higher-Order Aberrations (HOAs)
Root mean square (RMS) of total higher-order aberrations measured using the OPD-Scan III. Units: micrometres (µm)
Time frame: 3 months
Effective Optical Zone Diameter
Effective optical zone diameter measured using the Pentacam system. Units: millimetres (mm)
Time frame: 3 months
Central Corneal Thickness
Central corneal thickness measured using the Pentacam system. Units: micrometres (µm)
Time frame: 3 months
Coma Aberration (RMS)
Coma aberration (root mean square) measured using the OPD-Scan III. Units: micrometres (µm)
Time frame: 3 months
Trefoil Aberration (RMS)
Trefoil aberration (root mean square) measured using the OPD-Scan III. Units: micrometres (µm)
Time frame: 3 months
Spherical Aberration (Zernike Z₄⁰, RMS)
Spherical aberration expressed as Zernike coefficient Z₄⁰ (RMS), measured using the OPD-Scan III. Units: micrometres (µm)
Time frame: 3 months
No study locations are listed for this record.
Plan to share: No
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This study is not yet recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Tianjin Eye Hospital