An interventional study of Wiping with wet wipes containing 2% chlorhexidine gluconate (CHG). in Urethral Stricture, sponsored by Second Affiliated Hospital, School of Medicine, Zhejiang University. Not yet recruiting. Open to male participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-04-02.
Sponsored by Second Affiliated Hospital, School of Medicine, Zhejiang University · Not applicable, Interventional, and Prevention
Male urethral stricture is one of the common diseases in urology, with risk factors including a history of hypospadias surgery, indwelling urinary catheterization or instrumental manipulation, trauma, transurethral surgery, and prostate cancer treatment. Its main clinical manifestations are dysuria, weak urinary stream and frequent micturition, which seriously affect patients' quality of life.
Surgery is the main treatment for moderate to severe urethral stricture. Among various surgical procedures, lingual mucosal urethroplasty and end-to-end urethral anastomosis are widely used in clinical practice due to their high long-term patency rates. However, postoperative complications still plague patients. According to reports, the incidence of urinary tract infection within 30 days after surgery ranges from 6.7% to 21%, and the incidence of surgical site infection (SSI) reaches 4.1%. SSI not only impairs surgical efficacy, but also may prolong hospital stay, increase medical costs and even lead to poor prognosis. As defined by the U.S. Centers for Disease Control and Prevention (CDC), SSI refers to surgery-related infections occurring within 30 days after surgery (or up to 1 year if an implant is present), which are specifically classified into three types: superficial incisional SSI, deep incisional SSI, and organ/space SSI. There are significant regional differences in the global incidence of SSI: it is approximately 2.8% in developed countries, while it can be as high as 22.8% in resource-limited regions, indicating an urgent need to optimize perioperative infection prevention and control strategies.
The World Health Organization (WHO) has identified standardized preoperative skin preparation as one of the key measures for preventing SSI. The skin is the main source of bacterial colonization in the surgical area. In particular, the perineum, due to its moist environment, numerous folds and easy accumulation of secretions, is prone to becoming a breeding ground for opportunistic pathogens such as Escherichia coli, Klebsiella pneumoniae, Staphylococcus epidermidis and Enterococcus faecalis-all of which are common pathogenic bacteria causing postoperative infections in male patients with urethral stricture.
Effective preoperative skin cleansing can significantly reduce the local microbial load and the risk of intraoperative contamination, thereby lowering the probability of postoperative infection. Therefore, preoperative skin preparation is not only a routine nursing procedure, but also a crucial component of perioperative infection control. Traditional preoperative skin preparation mostly involves wiping with warm water or normal saline, which can remove surface dirt but lacks sustained antibacterial effects and is difficult to effectively inhibit bacterial regrowth. In recent years, chlorhexidine gluconate (CHG) has gradually become the preferred product for preoperative skin disinfection due to its broad-spectrum antibacterial activity, rapid bactericidal effect and persistent residual action. A number of high-quality studies have confirmed that preoperative showering or local wiping with CHG can significantly reduce the incidence of SSI in orthopedic surgery, cesarean section and implantation of cardiac electronic devices.
However, in the field of urology, especially for complex urethral reconstructive surgeries involving the perineal region (such as lingual mucosal urethroplasty and end-to-end urethral anastomosis), studies on the inhibitory effect of local CHG application on skin bacterial colonization and its clinical value remain scarce. Such surgeries are classified as "clean-contaminated" procedures, characterized by long operative time and extensive tissue exposure. In addition, some surgical techniques require tissue harvesting from the oral cavity, which brings the risk of multiple infection sources and imposes higher requirements for aseptic management of the surgical area. Existing studies mostly take postoperative infection rate as the endpoint indicator, and few focus on the impact of preoperative interventions on the dynamic changes of skin microorganisms. Quantitative detection of colony-forming units (CFU) and bacterial species distribution in key anatomical sites can more objectively evaluate the immediate and sustained bacteriostatic effects of different skin preparation methods, thereby revealing their underlying mechanisms of action.
Therefore, this study intends to conduct a prospective research to compare the bacteriostatic effects of different preoperative skin preparation methods in the target population, so as to provide clinical practice with more evidence-based guidelines for perioperative skin preparation procedures.
72 studies on the registry are indexed under Urethral Stricture; 25 are open to participants now.
This study's planned enrollment of 40 is below the median of 60 across 56 interventional studies indexed under Urethral Stricture.
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Male patients aged ≥18 years with a clinically confirmed diagnosis of urethral stricture, who are scheduled to undergo lingual mucosal urethroplasty or end-to-end urethral anastomosis.
Possess normal cognitive and communication abilities, and be able to cooperate with preoperative cleaning procedures and postoperative follow-up.
No history of topical antimicrobial therapy on the perineal region before surgery, and no systemic antibiotic administration within 1 week prior to surgery.
Voluntarily participate in this study and sign the form.
Exclusion Criteria:
Complicated with severe systemic infectious diseases, or suffering from immunodeficiency diseases (e.g., AIDS, long-term use of ).
Presence of skin damage, ulcers, eczema or other dermatoses on the perineal skin, which may interfere with cleaning procedures and bacterial sample collection.
A definite history of allergy to chlorhexidine gluconate (CHG) or study-related supplies.
Having surgical such as severe hepatic and renal insufficiency, or coagulation dysfunction.
Inability to cooperate with preoperative cleaning procedures, or failure to complete postoperative follow-up due to personal reasons
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Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
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Immunosuppression
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Wiping with wet wipes containing 2% chlorhexidine gluconate (CHG). Frequency and sites of wiping: Twice daily for 3 to 5 days before surgery. The urethral orifice, penis, scrotum and the perineal surrounding skin were disinfected.
Other: Wiping with wet wipes containing 2% chlorhexidine gluconate (CHG).
Wiping with a warm water-soaked towel, with the same wiping frequency and sites as the intervention group.
Wiping with wet wipes containing 2% chlorhexidine gluconate (CHG). Frequency and sites of wiping: Twice daily for 3 to 5 days before surgery. The urethral orifice, penis, scrotum and the perineal surrounding skin were disinfected.
the bacterial load and the identified bacterial species
Sterile cotton swabs moistened with normal saline were used to collect bacterial samples from three sites: the inner surface of the penile foreskin, the penoscrotal junction, and the base of the scrotum. The bacterial load (CFU/cm², a quantitative index expressed as colony-forming units) and the identified bacterial species were recorded.
Time frame: Sampling was performed at three time points: before wiping, after wiping (on the morning of the operation day), and on the 3rd postoperative day (when the wound dressing was removed).
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Plan to share: Undecided
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This study is not yet recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Second Affiliated Hospital, School of Medicine, Zhejiang University →