An interventional study of periodontal non-surgical treatment in Periodontitis, Smoking Cessation and Tobacco Dependence, sponsored by University of Liege. Enrolling by invitation at 1 site in Belgium. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-04-22.
Sponsored by University of Liege · Not applicable, Interventional, and Prevention
Impact of nicotine gingival intoxication on the clinical outcomes after periodontitis non surgical treatment
In patients suffured of periodontitis, to evaluate the effect of nicotine gingival tissue intoxication and others smoking indicators on the severity of periodontitis and outcomes after nonsurgical periodontal treatment."
1,637 studies on the registry are indexed under Periodontitis; 327 are open to participants now.
This study's planned enrollment of 56 is above the median of 45 across 1,191 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →University of Liege is the lead sponsor of 242 studies on the registry; 46 are open to participants now.
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Inclusion Criteria: patient suffured of periodontitis, smoker and non-smoker
Exclusion Criteria:
patient who smokes conventionnal cigarette
Procedure: periodontal non-surgical treatment
patient who don't smoke cigarette
Procedure: periodontal non-surgical treatment
The procedure will consist of non-surgical periodontal treatment (NSPT), consisting of the removal of supra- and subgingival plaque using ultrasonic instruments. Prior to the NSPT, all unstimulated saliva will be collected using Eppendorf. During local anesthesia for the NSPT, a gingival tissue biopsy will be performed using a 2mm wide and 4mm deep punch in the maxillary retromolar area behind the last tooth in the arch.
nicotine/cotinine in gum (ng/ml)
concentration cotinine and nicotine (ng/ml)
Time frame: the day of the periodontal non surgical treatment
PD (mm)
periodontal pocket depth (mm) Secondary outcomes: percentage of sites with PD ≥ 6 mm, furcation involvement, mobility assessment, bleeding on probing score (BoP), plaque score (PI).
Time frame: baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after
% PD ≥ 6 mm (%)
percentage of sites with PD ≥ 6 mm
Time frame: baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after
FTND score ( 0 to 9)
Fagerström test for nictnie dependance ( scale from 0 to 9) 0-2: Very low dependence 3-4: Low dependence 5: Medium dependence 6-7: High dependence 8-10: Very high dependence
Time frame: the day of periodontal non-surgical treatment
PY (number/year)
number of packet of cigarettes smoked per year
Time frame: the day of periodontal non-surgical treatment
NCC (0 to 100)
number of cigartes consummed per day * PK: number of packet of cigarettes smoked per year * FTND: Fagerström test for nictnie dependance
Time frame: the day of periodontal non-surgical treatment
Furc (I,II or III)
furcation involvement
Time frame: baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after
periodontal ouctomes
tooth mobility ( 1,2 or 3)
Time frame: baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after
BOP (%)
bleeding on probing
Time frame: baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after
PI (%)
plaque score
Time frame: baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after
Plan to share: No
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University of Liege