An interventional study of Scaling and root planing and Photodynamic Therapy with Conventional Methylene Blue in Type 2 Diabetes, Halitosis and Periodontitis, sponsored by University of Sao Paulo. Recruiting at 1 site in Brazil. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-03-16.
Sponsored by University of Sao Paulo · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to evaluate the effectiveness of periodontal treatment associated with the use of a tongue scraper, compared with the same treatment combined with antimicrobial photodynamic therapy (aPDT), in reducing halitosis in individuals with periodontal disease and type 2 diabetes mellitus. The main question it aims to answer is: aPDT treatment is more effective in treating halitosis? aPDT treatment is more effective in periodontitis? Researchers will compare aPDT treatment to conventional treatment (scaling and root planning and tongue scraper) to see if aPDT has additional effects in reducing halitosis and improving periodontal health.
10,371 studies on the registry are indexed under Diabetes Mellitus, Type 2; 1,406 are open to participants now.
This study's planned enrollment of 32 is below the median of 80 across 8,350 interventional studies indexed under Diabetes Mellitus, Type 2.
Browse Diabetes Mellitus, Type 2 studies →University of Sao Paulo is the lead sponsor of 1,035 studies on the registry; 95 are open to participants now.
Of its 8 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Treatment of scaling and root planning plus antimicrobial photodynamic therapy in periodontal pockets. Antimicrobial photodynamic therapy on tongue.
Procedure: Photodynamic Therapy with Conventional Methylene Blue
Treatment of periodontal pockets with scaling and root planing and tongue with tongue scraper
Procedure: Scaling and root planing
Mechanical removal of biofilm in periodontal pockets and tongue
Antimicrobial photodynamic therapy in periodontal pockets and tongue
Halitosis
Measurement of oral volatile compounds by gas chromatography
Time frame: From enrollment to the end of treatment at 6 months
Probing depth
Measurement in milimeters of the periodontal pocket
Time frame: From enrollment to the end of treatment at 6 months
Clinical Attachment level
Measuremet in milimeters from cementoenamel junction to bottom of the pocket
Time frame: From enrollment to the end of treatment at 6 months
Plan to share: Undecided
Start is estimated for Apr 2026; primary completion for Jan 2027, 9 months later.
Of 2,066 non-industry interventional studies with no phase under Diabetes Mellitus, Type 2, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 40. This study's planned 9 months is below that.
Counting every sponsor, half of 2,243 studies reached it within 21 months; a quarter within 10 and three quarters within 39.
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