An observational study in Keratoconus, sponsored by Minia University. Active, not recruiting at 1 site in Egypt. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-11.
Sponsored by Minia University · Observational
Keratoconus is a bilateral and asymmetric disease which results in progressive thinning and steeping of the cornea leading to irregular astigmatism and decreased visual acuity.A typical patient with keratoconus presents in the teens or early twenties with complaints of blurring or distortion in vision and having to change glasses frequently due to changes in refractive error.
Corneal thinning frequently precedes ectasia. In moderate and advance cases, a hemosiderin arc or circle line, known as Fleischer's ring, is frequently seen around the cone base. Vogt's striaes, which are fine vertical lines produced by Descemet's membrane compression, is another characteristic sign. Most patients eventually develop corneal scarring. Munson's sign, a V-shape deformation of the lower eyelid in downward position; Rizzuti's sign, a bright reflection from the nasal area of the limbus when light is directed to the limbus temporal area; and breakages in Descemet's membrane causing acute stromal oedema, known as hydrops, are observed in advanced stages.
Corneal blindness is one of the major causes of reversible blindness, which can be managed with transplantation of a healthy donor cornea. It is the most successful organ transplantation in the human body as cornea is devoid of vasculature, minimizing the risk of graft rejection.
Preoperative clinical evaluation of visual potential after corneal transplantation in the patient with dense corneal opacity remains difficult using only history and biomicroscopic examination. Some studies found that electrophysiologic tests were good predictors of visual prognosis prior to corneal transplantation.
Electrophysiology is an objective functional test of the visual pathway and allows the location of visual dysfunctions to be detected. Full-field electroretinography (ERG) is an established clinical technique used to evoke and record mass responses of the retina to flashes of light. The ISCEV Standard full-field ERGs assess generalized retinal function under dark-adapted (DA) and light-adapted (LA) conditions.The visual evoked potential (VEP) is a cortical response and serves as a functional test of the entire visual pathway from the eye to the visual system of the brain.
Aim of the Study To assess the effect of different stages of keratoconus on electrophysiology test results.
All patients will undergo a comprehensive ocular examination including:
All subjects will be examined using:
307 studies on the registry are indexed under Keratoconus; 56 are open to participants now.
This study's planned enrollment of 50 is below the median of 130 across 94 observational studies indexed under Keratoconus.
Browse Keratoconus studies →Minia University is the lead sponsor of 356 studies on the registry; 115 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Study participants will be : from 18 to 40 years old:
50 eyes of control patients 50 eyes of patients who had KC
Exclusion criteria:
Patients with different stages of keratoconus
patients whose pentacam doesn't show any keratoconus findings or any other abnormalities
Measuring the amplitude of P100 wave in pattern visual evoked potential
Measuring the amplitude of P100 wave of pattern visual evoked potential in mico-voltage in different stages of keratoconus using the (Roland Consult Supercolor Ganzfeld Q450 SC)
Time frame: 6 months
Measuring the Latency of P100 wave of pattern evoked potential
Measuring the latency of P100 wave of pattern visual evoked potential in mico-second in different stages of keratoconus using the (Roland Consult Supercolor Ganzfeld Q450 SC)
Time frame: 6 months
Measuring the Amplitude of P2 of Flash visual evoked potential
Measuring the amplitude of P2 wave of Flash visual evoked potential in mico-voltage in different stages of keratoconus using the (Roland Consult Supercolor Ganzfeld Q450 SC)
Time frame: 6 months
measuring the latency of P2 wave of Flash visual evoked potential
Measuring the latency of P2 wave of Flash visual evoked potential in mico-second in different stages of keratoconus using the (Roland Consult Supercolor Ganzfeld Q450 SC)
Time frame: 6 months
Measuring the Amplitude of a wave of Full Field Flash Electroretinography
Measuring the amplitude of a wave of full field flash ERG in mico-voltage in different stages of keratoconus using the (Roland Consult Supercolor Ganzfeld Q450 SC)
Time frame: 6 months
measuring the implicit time of a wave of Full Field Flash Electroretinography
Measuring the Implicit time of a wave of full field flash ERG in mico-second in different stages of keratoconus using the (Roland Consult Supercolor Ganzfeld Q450 SC)
Time frame: 6 months
Measuring the amplitude of b wave of Full Field Flash Electroretinography
Measuring the amplitude of b wave of full field flash ERG in mico-voltage in different stages of keratoconus using the (Roland Consult Supercolor Ganzfeld Q450 SC)
Time frame: 6 months
Measuring the implicit time of b wave of Full Field Flash Electroretinography
Measuring the implicit time of b wave of full field flash ERG in mico-second in different stages of keratoconus using the (Roland Consult Supercolor Ganzfeld Q450 SC)
Time frame: 6 months
Plan to share: Undecided
This study is active, not recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Minia University