An interventional study of Low-sodium salt substitute in Hypertension, sponsored by Johns Hopkins University. Recruiting at 1 site in Bangladesh. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-21.
Sponsored by Johns Hopkins University · Not applicable, Interventional, and Treatment
The goal of this pre-post study is to assess the risk of hyperkalemia in adults with hypertension on medication in Bangladesh. The main questions it aims to answer are:
Is the risk of hyperkalemia after the initiation of Low Sodium Salt Substitute (LSSS) in people on antihypertensive medication (especially RASi) large enough to be concerned about its broad use in this population?
Does initiation of LSSS correct hypokalemia in people on antihypertensive medication (especially RASi) with low serum potassium levels?
Participants will be asked to reduce overall salt intake and to use LSSS on every occasion where regular salt would normally be used, including as cooking salt.
6,689 studies on the registry are indexed under Hypertension; 965 are open to participants now.
This study's planned enrollment of 607 is above the median of 90 across 4,995 interventional studies indexed under Hypertension.
Browse Hypertension studies →Johns Hopkins University is the lead sponsor of 1,783 studies on the registry; 313 are open to participants now.
Of its 203 completed or terminated interventional studies of FDA-regulated products, 140 (69%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants are asked to reduce overall salt intake and to use LSSS on every occasion where regular salt would normally be used, including as cooking salt
Dietary Supplement: Low-sodium salt substitute
The low sodium salt substitute contains 25% potassium chloride (KCl range; 20%-35%)
Incident hyperkalemia (K ≥5.5 mmol/L)
Time frame: 4 and 8 weeks
Proportion of the correction of hypokalemia (from K <3.5 mmol/L to 3.5-5.0 mmol/L)
Time frame: 4 and 8 weeks
Change in serum potassium levels
Time frame: 4 and 8 weeks
Change in systolic and diastolic blood pressure (mmHg)
Time frame: 4 and 8 weeks
Number of Participants Adherent to LSSS use
Time frame: 4 and 8 weeks
Plan to share: No — Individual participant data will not be shared due to institutional review board restrictions and participant privacy considerations.
No publications or documents are linked to this record.
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