An interventional study of wall-squat and wall-squat-tradition in Hypertension (HTN) and Pre Hypertension, sponsored by University of Hartford. Recruiting at 1 site in United States. Open to participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-01.
Sponsored by University of Hartford · Not applicable, Interventional, and Prevention
High blood pressure is a common medical condition that affects the body's arteries. It's also called hypertension. Untreated hypertension increases the risk of heart attack, stroke and other serious health problems. Exercise is a promising tool in hypertension management. Regular participation in exercise improves vascular health, heart and lung function, and multisystem health. However, the direct evidence of the treatment effects of a brief period of exercise on blood pressure in individuals with hypertension is limited. A brief period of exercise refers to an exercise protocol that only lasts for a very short period of time, such as 5-10 minutes.
The study will investigate both acute and long-term effects of a brief exercise on blood pressure. For the acute effect, participants will conduct a single bout of resistance exercise (leg press) with or without blood flow restriction technique. The blood pressure changes from pre- to post-exercise will be monitored. The long-term effect of exercise on blood pressure will be examined through a six to eight weeks home-based intervention program. Participants will conduct two forms of exercise, one is a clustered wall-sit exercise and the other is a scattered wall-sit exercise.
6,114 studies on the registry are indexed under Hypertension; 912 are open to participants now.
This study's planned enrollment of 45 is below the median of 100 across 4,575 interventional studies indexed under Hypertension.
Browse Hypertension studies →University of Hartford is the lead sponsor of 16 studies on the registry; 4 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Current medical history of any of the following:
hyperaldosteronism Diabetes mellitus (Type 1 or type 2) Heart disease Stroke or Peripheral neuropathy Aortic aneurysm and/or peripheral arterial disease If female, pregnancy or currently breast feeding Enrolled in another Clinical Trial of an Interventional Medicinal Product or Medical Device or other interventional study Medical condition that, in the opinion of the investigator, would make the participant unsuitable for the study On long term warfarin Allergies to blood pressure cuff materials or ultrasound gel
Previous medication history of any of the following:
hyperaldosteronism Heart disease Stroke or transient ischemic attack Peripheral neuropathy Aortic aneurysm and/or peripheral arterial disease thromboembolism Infection within limb within 3 months On long term warfarin Allergies to blood pressure cuff materials or ultrasound gel
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A “mini-stroke”: temporary stroke-like symptoms caused by reduced blood flow to part of the brain, spinal cord or eye, without signs of a new stroke on a scan.
Stroke symptoms need emergency care at once, even if they go away.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
TIA (transient ischaemic attack)
A “mini-stroke”: temporary stroke-like symptoms caused by reduced blood flow to part of the brain, spinal cord or eye, without signs of a new stroke on a scan.
Stroke symptoms need emergency care at once, even if they go away.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Behavioral: wall-squat-tradition
Behavioral: wall-squat
the experimental group will complete the four sets of wall-squats at four different times across the day: morning, noon, afternoon, night.
The other exercise group will do 4 sets of wall squat in a continuous way.
24 h blood pressure
The average, peak and variations of 24 h SBP and DBP, daytime SBP and DBP, night time SBP and DBP will be measured before and after the intervention.
Time frame: From the enrollment to the end of the study at six weeks
endothelial function
endothelial function measured by flow mediated dilation
Time frame: at baseline (Day 1) and Week 6
arterial stiffness
arterial stiffness measured by pulse wave velocity
Time frame: at baseline (Day 1) and week 6
Plan to share: Yes — The data and protocol can be shared with other researchers by request after publication.
Supporting information: Study protocol, Statistical analysis plan, Clinical study report
Time frame: The IPD information will be available 1-1-2027 for six months.
No publications or documents are linked to this record.
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