An observational study in Liver Cirrhosis, Hepatic Encephalopathy and TIPS, sponsored by The Second Affiliated Hospital of Chongqing Medical University. Active, not recruiting at 1 site in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-02-27.
Sponsored by The Second Affiliated Hospital of Chongqing Medical University · Observational
This study aims to develop a practical tool for identifying cirrhotic patients at high risk of hepatic encephalopathy following transjugular intrahepatic portosystemic shunt (TIPS) placement. A retrospective analysis will be conducted on medical records of 624 cirrhotic patients who underwent TIPS from 2011 to 2021. Statistical methods will be applied to screen preoperative routine indicators associated with post-TIPS hepatic encephalopathy risk. A predictive nomogram will be constructed incorporating the screened indicators to estimate individual preoperative risk. The predictive performance will be compared with conventional clinical scoring systems. This tool is intended to facilitate preoperative risk evaluation and targeted management of high-risk patients undergoing TIPS
Background: Transjugular intrahepatic portosystemic shunt (TIPS) is an important treatment for the complications of portal hypertension. However, hepatic encephalopathy remains a major complication after TIPS, and its independent risk factors are not fully elucidated. The purpose of this study is to investigate the independent risk factors of hepatic encephalopathy (HE) after TIPS in patients with liver cirrhosis, and to construct a nomogram model to identify high-risk patients before TIPS.
Method: This retrospective study will include cirrhotic patients who underwent TIPS at the Second Affiliated Hospital of Chongqing Medical University between 2011 and 2021. Patients will be randomly split into training (70%) and validation (30%) cohorts. Predictors will be selected using LASSO regression with cross-validation and further analyzed via multivariable logistic regression to build a nomogram. Model performance will be evaluated and compared with conventional scores (MELD, MELD-Na, ALBI, FIPS).
Result: To be reported after study completion. Conclusion: A nomogram based on routine preoperative variables is hypothesized to predict HE risk after TIPS. This study intends to provide a tool for preoperative risk stratification and individualized patient management.
Keywords: cirrhosis; transjugular intrahepatic portosystemic shunt; hepatic encephalopathy; prognosis; nomogram
1,642 studies on the registry are indexed under Liver Cirrhosis; 358 are open to participants now.
This study's enrollment of 624 is above the median of 151 across 587 observational studies indexed under Liver Cirrhosis.
Browse Liver Cirrhosis studies →The Second Affiliated Hospital of Chongqing Medical University is the lead sponsor of 98 studies on the registry; 29 are open to participants now.
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This retrospective study included 624 patients with liver cirrhosis who underwent TIPS at the Second Affiliated Hospital of Chongqing Medical University between May 2011 and December 2021
Exclusion Criteria:
Cirrhotic patients who underwent TIPS and were subsequently diagnosed with hepatic encephalopathy within 3 months after the procedure, as identified through a retrospective review of electronic medical records.
Cirrhotic patients who underwent TIPS and remained free from a diagnosis of hepatic encephalopathy throughout the 3-month follow-up period after the procedure, as confirmed by retrospective review of medical records
Occurrence of hepatic encephalopathy within 3 months after TIPS
The development of hepatic encephalopathy, diagnosed based on clinical assessment and medical records during follow-up outpatient visits or hospital readmissions within 3 months after the TIPS procedure. All HE cases in this study occurred within this period.
Time frame: 3-month follow-up after TIPS
Plan to share: No — The individual participant data collected for this observational study contain sensitive personal health information (e.g., detailed clinical outcomes and laboratory results). To protect participant privacy and confidentiality in accordance with local data protection regulations and the approved ethics protocol, the datasets will not be publicly deposited. Data are owned by the chongqing Medical University and may be available upon reasonable request to the corresponding author for purposes of verification or collaborative research, subject to a formal data sharing agreement and institutional approvals.
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This study is active, not recruiting, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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The Second Affiliated Hospital of Chongqing Medical University