An observational study in Scoliosis, sponsored by Istanbul University. Not yet recruiting. Open to participants aged 8 Years to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-27.
Sponsored by Istanbul University · Observational
Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that may affect musculoskeletal development and posture in children. Spinal involvement, including scoliosis, is not routinely evaluated in clinical practice despite its potential impact on functional status and quality of life.
This cross-sectional study aims to assess the presence of scoliosis in children with JIA and to investigate its association with functional status, postural alignment, and disease activity. Clinical and functional parameters will be analyzed to better understand the impact of spinal deformities in this population.
Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that may negatively affect musculoskeletal development, posture, and overall physical function in children. Although peripheral joint involvement is well characterized, axial and postural abnormalities, including scoliosis, are not routinely assessed during follow-up despite their potential clinical significance.
This cross-sectional study aims to evaluate the presence of scoliosis in children with JIA and to investigate its relationship with disease activity, functional status, pain, and postural alignment. Comprehensive clinical assessments, including physical examination, disease activity scores, and functional evaluation tools, will be performed. Where applicable, postural analysis and imaging findings will also be considered.
By identifying the frequency and clinical impact of scoliosis in JIA, this study seeks to improve awareness of spinal involvement and to provide a basis for early recognition and multidisciplinary management strategies, including targeted physiotherapy interventions.
594 studies on the registry are indexed under Scoliosis; 139 are open to participants now.
This study's planned enrollment of 200 is above the median of 89 across 233 observational studies indexed under Scoliosis.
Browse Scoliosis studies →Istanbul University is the lead sponsor of 496 studies on the registry; 79 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 1 (20%) have results posted.
Counted across the registry records on this site, refreshed daily.
The study population consists of children and adolescents aged 8-18 years diagnosed with juvenile idiopathic arthritis (JIA) according to ILAR criteria and followed up at a tertiary pediatric rheumatology center. Participants will be recruited consecutively during routine outpatient visits. The aim of the study is to evaluate the prevalence and severity of scoliosis, as defined by Cobb angle measurements on physical examination and, if necessary, standing spinal radiographs, and to examine its relationship with clinical and functional parameters. Both patients with and without scoliosis will be included in the study.
Exclusion Criteria
Children diagnosed with juvenile idiopathic arthritis (JIA) who have scoliosis, defined by a Cobb angle of ≥10 degrees on standing spinal radiographs. Clinical characteristics, disease activity parameters, and functional assessments including postural and plantar pressure analyses will be evaluated. No intervention will be applied; this group will be observationally assessed.
Children diagnosed with juvenile idiopathic arthritis (JIA) without evidence of scoliosis (Cobb angle \<10 degrees). Participants will undergo the same clinical, laboratory (if applicable), and functional assessments as the scoliosis group. This is an observational group with no intervention.
Prevalence of Scoliosis in Children With Juvenile Idiopathic Arthritis
Proportion of participants with scoliosis, defined as a Cobb angle ≥10° measured on standing spinal radiographs.
Time frame: At baseline (single study visit)
Scoliosis Severity (Cobb Angle)
Cobb angle (degrees) measured on standing spinal radiographs. Scoliosis defined as Cobb angle ≥10°.
Time frame: At baseline (single study visit)
Health-Related Quality of Life (PedsQL)
Health-related quality of life assessed using the Pediatric Quality of Life Inventory (PedsQL) total score (and physical and psychosocial subscale scores, if available). Scores are transformed to a 0-100 scale (range: 0-100), with higher scores indicating better health-related quality of life.
Time frame: At baseline (single study visit)
No study locations are listed for this record.
Plan to share: Undecided — The decision to share individual participant data (IPD) has not yet been finalized. Data sharing may be considered upon reasonable request after publication, subject to institutional policies, ethical approvals, and data protection regulations.
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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Istanbul University