An interventional study of electrical acupoint stimulation and electrodes pasted in Anesthesia, Post-induction Hypotension (PIH) and Transcutaneous Electrical Acupoint Stimulation, sponsored by Zhihong LU. Not yet recruiting. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2026-09-15.
Sponsored by Zhihong LU · Not applicable, Interventional, and Treatment
From 15 minutes before to 15 minutes after anesthesia, Transcutaneous Electrical Acupoint Stimulation(TEAS) at different frequencies will be applied at Neiguan and Jian Shi. The changes in blood pressure during the anesthesia induction period will be compared among the high-frequency group ,the low-frequency group and the control group to explore the better frequency to reduce the incidence of post-induction hypotension(PIH) in the elderly.
885 studies on the registry are indexed under Hypotension; 195 are open to participants now.
This study's planned enrollment of 204 is above the median of 87 across 590 interventional studies indexed under Hypotension.
Browse Hypotension studies →Zhihong LU is the lead sponsor of 17 studies on the registry; 7 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
The New York Heart Association’s four classes of how much heart failure limits physical activity.
Studies set their own limit — many outside heart failure leave out class III–IV, while heart failure studies may ask for a particular class. Check the class this study names.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
NYHA class (heart failure)
The New York Heart Association’s four classes of how much heart failure limits physical activity.
Studies set their own limit — many outside heart failure leave out class III–IV, while heart failure studies may ask for a particular class. Check the class this study names.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The electrical stimulation is provided at a frequency of 100Hz
Other: electrical acupoint stimulation · Other: electrodes pasted · Other: high-frequency electrical stimulation
The electrical stimulation is provided at a frequency of 2Hz
Other: electrical acupoint stimulation · Other: electrodes pasted · Other: low-frequency electrical stimulation
Only electrodes are pasted
Other: electrodes pasted
electrical acupoint stimulation are administered at Neiguan and Jian Shi. The stimulation starts at 15 minutes before anesthesia induction and ends at 15 minutes after anesthesia induction.
Electrodes are pasted at Neiguan and Jianshi
The frequency of electrical stimulation is 100Hz
The frequency of electrical stimulation is 2Hz
incidence of hypotension
Hypotension is defined as a Mean arterial pressure (MAP) reduction of more than 20% from baseline or a MAP less than 65 mm Hg for at least 30 seconds. The baseline MAP is measured during the 5 minutes before start of intervention
Time frame: from start of anesthesia induction to 15 minutes after induction
The area under the curve representing the change in mean arterial pressure during the induction period relative to the baseline.
The area under the curve (AUC) below baseline mean arterial pressure (MAP) is calculated as: ∑ (((Si - Sbaseline)+(Si-1 - Sbaseline))/2 × ΔX) where Sbaseline is the baseline MAP, Si is the MAP at the i-th minute (i = 1…15), and ΔX is the time interval between two measurements.
Time frame: from start of induction to 15 minutes after induction
The dosage of vasoactive drugs
Any MAP drop by more than 20% from baseline or a MAP less than 65 mm Hg for at least 1 minute within the first 15 minutes after general anesthesia induction triggered the administration of norepinephrine boluses (5 μg). If hypotension persisted after 2 boluses, a norepinephrine infusion (0.02-0.3 μg/kg/min) was initiated and continued until the MAP became stable and reached 65 mm Hg or higher. If hypotension reoccurred, 2 boluses of norepinephrine were repeated.
Time frame: from start of induction to 15 minutes after induction
lowest MAP
Time frame: from start of induction to 15 minutes after induction
standard deviation of R-R intervals (SDRR)
assessed from the electrocardiography, key index of heart rate variability (HRV)
Time frame: from start of induction to 15 minutes after induction
ratio of low-frequency HRV/high-frequency HRV (LF/HF ratio)
assessed from the electrocardiography,High-frequency HRV (HF-HRV) at 0.15-0.4 Hz and low-frequency HRV (LF-HRV) at 0.04-0.15 Hz
Time frame: from start of induction to 15 minutes after induction
major in-hospital complication incidence within 5 postoperative days
major in-hospital complication incidence within 5 postoperative days
Time frame: from start of anesthesia to the 5 days after anesthesia
No study locations are listed for this record.
Plan to share: Yes — The de-identified data will be available with reasonable request from Dr. Zhihong Lu at deerlu23@163.com
Supporting information: Study protocol
Time frame: after publication
Access criteria: with request to Dr. Zhihong Lu
Start is estimated for Sep 2026; primary completion for Dec 2026, 3 months later.
Of 210 non-industry interventional studies with no phase under Hypotension, half reached primary completion within 12 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 22. This study's planned 3 months is below that.
Counting every sponsor, half of 217 studies reached it within 12 months; a quarter within 6 and three quarters within 22.
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This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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