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Not yet recruitingNCT06521632TREACLEUpdated Jul 26, 2024

Acupoint Stimulation Improves Cognition Under Hypoxia

An interventional study of transcutaneous electrical acupoint stimulation in Cognition, sponsored by Zhihong LU. Not yet recruiting at 1 site in China. Open to male participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-07-26.

Sponsored by Zhihong LU · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Apr 2025, 1 year 6 months ago, but the record still lists the study as not yet recruiting.
Phase
Not applicable
Study type
Interventional
Enrollment
50
Allocation
Randomized
Ages
18 Years to 50 Years
Sex
Male
01

Study summary

Cognitive impairment is common in people who suffer from hypoxia. Acupuncture and related techniques can be used to improve hypoxia and treat cognitive impairment. In this trial the effect of transcutaneous electrical acupoint stimulation on cognitive impairment in people under hypoxia will be investigated.

02

Conditions studied

  • Cognition

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Keywords

  • transcutaneous electrical acupoint stimulation
  • cognition
  • hypoxia
03

In context

Hypoxia

1,076 studies on the registry are indexed under Hypoxia; 213 are open to participants now.

This study's planned enrollment of 50 is above the median of 45 across 769 interventional studies indexed under Hypoxia.

Browse Hypoxia studies →

Lead sponsor

Zhihong LU is the lead sponsor of 17 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 50 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Male, age from 18 to 50 years

Exclusion criteria

Exclusion Criteria:

  • cardiopulmonary dysfunction;
  • History of severe respiratory, circulatory, digestive, blood, ear-nose-throat system diseases;
  • A history of fever or respiratory infection within the last two weeks;
  • Drinking alcohol or poor sleep within the last 24 hours
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double (Investigator, Outcomes assessor)
Enrollment
50 participants (estimated)

Study arms

  • Experimental
    transcutaneous electrical acupoint stimulation

    Electrodes are placed at acupoints and connected to the stimulators. Electrical stimulation is given for 2 hours

    Other: transcutaneous electrical acupoint stimulation

  • No intervention
    Control

    Electrodes are placed at acupoints but no electrical stimulation is given

Interventions

  • Othertranscutaneous electrical acupoint stimulation

    Electrodes are placed at acupoints and connected to the stimulator. Electrical stimulation is given for 2 hours.

06

What researchers measure

Primary outcomes

  1. cognitive function measured by eye-tracking at 1 hour after hypoxia

    Time frame: 1 hour after hypoxia

  2. cognitive function measured by eye-tracking at 2 hours after hypoxia

    Time frame: 2 hours after hypoxia

Secondary outcomes

  1. mean arterial blood pressure

    Time frame: starting from 10 minutes before hypoxia to 2 hours after hypoxia, every 5 minutes for 2 hours and 10 minutes

  2. heart rate

    Time frame: starting from 10 minutes before hypoxia to 2 hours after hypoxia, every 5 minutes for 2 hours and 10 minutes

  3. saturation of pulse oximetry

    Time frame: starting from 10 minutes before hypoxia to 2 hours after hypoxia, every 5 minutes for 2 hours and 10 minutes

  4. Cerebral oxygen saturation

    Time frame: starting from 10 minutes before hypoxia to 2 hours after hypoxia, every 5 minutes for 2 hours and 10 minutes

  5. total sleep time on the first day after hypoxia

    Time frame: the first day after hypoxia, in a total of 24 hours

  6. sleep efficiency(%) on the first day after hypoxia

    sleep efficiency=total sleep time/total recording time

    Time frame: the first day after hypoxia, in a total of 24 hours

  7. number of awake on the first day after hypoxia

    Time frame: the first day after hypoxia, in a total of 24 hours

  8. time of awake on the first day after hypoxia

    Time frame: the first day after hypoxia, in a total of 24 hours

07

Study locations

1 site
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 26, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06521632
Lead sponsor
Zhihong LU
Responsible party
Zhihong LU (Associate professor, Air Force Military Medical University, China) — Sponsor-investigator
First posted
Jul 26, 2024
Start date
Jul 30, 2024 (estimated)
Primary completion
Apr 30, 2025 (estimated)
Completion
May 7, 2025 (estimated)
Last update
Jul 26, 2024

Study contacts

Zhihong Lu
Contact
deerlu23@163.com
+8613891975018

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Jul 2024. You cannot join it, but the record below documents what was studied.

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