An interventional study of YOGA and physical exercise in Endometriosis, Chronic Pain and Dysmenorrhea, sponsored by Beneficência Portuguesa de São Paulo. Completed at 1 site in Brazil. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-02-24.
Sponsored by Beneficência Portuguesa de São Paulo · Not applicable, Interventional, and Treatment
two-arm randomized parallel-group trial comparing an 8-week online yoga program versus a conventional physical exercise program.
Study Design
Study Type Interventional (Clinical Trial)
Primary Purpose Treatment
Allocation Randomized
Intervention Model Parallel Assignment
Masking None (Open Label)
Number of Arms 2
Interventional Study Model Description (opcional) Two-arm randomized parallel-group trial comparing an 8-week online yoga program versus a conventional physical exercise program.
4. Conditions and Keywords
Condition Endometriosis
Keywords
Endometriosis
Chronic pelvic pain
Dysmenorrhea
Dyspareunia
Yoga
Physical exercise
Quality of life
5. Arms and Interventions Arm 1
Arm Type Experimental
Arm Name Yoga
Arm Description Participants assigned to the yoga arm received eight weekly 30-minute online group sessions delivered via videoconference by trained instructors. Each session included meditation, pranayama breathing techniques and a standardized sequence of seated and standing postures targeting relaxation, body awareness, flexibility and pelvic/lumbopelvic muscle balance.
Intervention Type Other
Intervention Name Yoga program
Intervention Description The yoga program consisted of eight 30-minute sessions delivered once weekly via Zoom or Google Meet. Sessions included an initial brief meditation, followed by pranayama techniques (e.g., Prana Shuddhi, Chandra Bhedana, Bhramari) and postures such as Sukhasana, Paschimottanasana, Gomukhasana, Baddha Konasana, Tadasana, Adho Mukha Svanasana, Anjaneyasana and Eka Pada Rajakapotasana, ending with Savasana. Participants were advised not to engage in other structured physical activity during the intervention period.
Arm 2
Arm Type Active Comparator
Arm Name Conventional Physical Exercise
Arm Description Participants assigned to the physical exercise arm received eight weekly 30-minute online group sessions focusing on functional strengthening and stretching of the hip and pelvis, delivered via videoconference by physical educators or physiotherapists.
Intervention Type Other
Intervention Name Conventional physical exercise program
Intervention Description The physical exercise program consisted of eight 30-minute sessions delivered once weekly via Zoom or Google Meet. Each session included four modules: 8 minutes of hip and lumbopelvic warm-up, 8 minutes of bodyweight squats, 8 minutes of strengthening exercises for hip and pelvic stabilizers (gluteus medius, gluteus maximus, tensor fasciae latae, piriformis, adductors/abductors), and 6 minutes of stretching to improve flexibility and muscle relaxation.
6. Outcome Measures Primary Outcome Measures
Use um desfecho primário claro (o artigo trata dor como foco principal). Exemplo:
Change in dysmenorrhea intensity (VAS 0-10)
Time Frame: Baseline (week 0) to week 8
Description: Difference in dysmenorrhea intensity measured on a 0-10 visual analogue scale (VAS), comparing yoga and physical exercise groups. Higher scores indicate more intense pain.
Change in deep dyspareunia intensity (VAS 0-10)
Time Frame: Baseline to week 8
Description: Difference in deep dyspareunia intensity measured on a 0-10 VAS, comparing yoga and physical exercise groups.
Change in non-cyclical pelvic pain intensity (VAS 0-10)
Time Frame: Baseline to week 8
Description: Difference in acyclical pelvic pain intensity measured on a 0-10 VAS, comparing yoga and physical exercise groups.
(Se o PRS exigir 1 primário apenas, escolha só dysmenorrhea VAS como Primary e marque os outros como Secondary.) Secondary Outcome Measures
Change in cyclic bowel symptom intensity (VAS 0-10)
Time Frame: Baseline to week 8
Description: Change in intensity of cyclic bowel symptoms/dyschezia on a 0-10 VAS.
Change in cyclic urinary symptom intensity (VAS 0-10)
Time Frame: Baseline to week 8
Description: Change in intensity of cyclic urinary symptoms/dysuria on a 0-10 VAS.
Change in SF-36 domain scores
Time Frame: Baseline to week 8
Description: Change in eight domains of the Short-Form 36 (functional capacity, physical role limitation, pain, general health, vitality, social functioning, emotional role limitation, mental health). Higher scores indicate better quality of life.
Change in EHP-30 domain scores
Time Frame: Baseline to week 8
Description: Change in domains of the Endometriosis Health Profile-30 (pain, control, emotional well-being, social support, self-image, work, sexual relations, medical care, treatment, infertility). Higher scores indicate worse health status.
Patient satisfaction with the intervention (Likert scale)
Time Frame: Week 8
Description: Overall satisfaction with the assigned intervention assessed on a Likert scale questionnaire (e.g., very dissatisfied to very satisfied).
Adherence to the intervention protocol
Time Frame: 8 weeks
Description: Proportion of participants who attended all eight scheduled sessions; reasons for non-adherence (scheduling conflicts, non-response, medical or personal reasons).
7. Eligibility Criteria
Inclusion Criteria
Women aged 18 to 45 years
Confirmed diagnosis of endometriosis by pelvic magnetic resonance imaging, transvaginal ultrasound with bowel preparation, or laparoscopy with histological confirmation
Presence of endometriosis-related pain (dysmenorrhea, deep dyspareunia, non-cyclical pelvic pain, dyschezia, or cyclical dysuria) with minimum intensity ≥3 on a 0-10 scale
Ability to participate in online sessions via videoconference
Provision of written informed consent
Exclusion Criteria
Active malignancy
Known infectious or inflammatory disease
Contraindications to practicing physical activity
Scheduled surgery during the 8-week study period
Initiation of new hormonal therapy during the study period
Age older than 45 years
Refusal or inability to provide informed consent
Sex/Gender: Female
Age Limits: 18 Years to 45 Years
Accepts Healthy Volunteers: No
8. Locations and Contacts
Countries of Recruitment Brazil
Facility 1
Name: Hospital BP - A Beneficência Portuguesa de São Paulo
City: São Paulo
Country: Brazil
Facility 2
Name: Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HCFMUSP)
City: São Paulo
Country: Brazil
Overall Official / Principal Investigator
Name: Maurício Simões Abrão, MD
Affiliation: Faculdade de Medicina da Universidade de São Paulo
9. Oversight / Ethics
Human Subjects Review Approved
IRB / Ethics Committee Name Research Ethics Committee of BP - Beneficência Portuguesa de São Paulo and the Endometriosis Outpatient Clinic of HCFMUSP
Ethics Approval Number 6.310.906
920 studies on the registry are indexed under Endometriosis; 266 are open to participants now.
This study's enrollment of 52 is below the median of 67 across 540 interventional studies indexed under Endometriosis.
Browse Endometriosis studies →Beneficência Portuguesa de São Paulo is the lead sponsor of 13 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants assigned to the yoga arm received eight weekly 30-minute online group sessions delivered via videoconference by trained instructors. Each session included meditation, pranayama breathing techniques and a standardized sequence of seated and standing postures targeting relaxation, body awareness, flexibility and pelvic/lumbopelvic muscle balance
Other: YOGA
Participants assigned to the physical exercise arm received eight weekly 30-minute online group sessions focusing on functional strengthening and stretching of the hip and pelvis, delivered via videoconference by physical educators or physiotherapists.
Other: physical exercise
The Yoga program incorporated meditation, pranayama breathing techniques, and physical postures aimed at relaxation, body awareness, and improvement of flexibility and muscle balance
The physical exercise protocol included joint warm-up, strengthening and stabilization exercises for the pelvis and hip, and stretching for mobility and muscle relief, focusing primarily on functional and resistance-based movements rather than aerobic or traditional weight-training components
Change in dysmenorrhea intensity (VAS 0-10)
Difference in dysmenorrhea intensity measured on a 0-10 visual analogue scale (VAS), comparing yoga and physical exercise groups. Higher scores indicate more intense pain.
Time frame: Baseline to week 8
Change in dysmenorrhea intensity (VAS 0-10)
Difference in dysmenorrhea intensity measured on a 0-10 visual analogue scale (VAS), comparing yoga and physical exercise groups. Higher scores indicate more intense pain.
Time frame: Baseline (week 0) to week 8
Plan to share: No
This study is completed, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Beneficência Portuguesa de São Paulo