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CompletedNCT07424300Updated Oct 20, 2026

Olfactory Function and Oral Malodor in Periodontitis Before and After Periodontal Therapy

An interventional study of Scaling and Root Planing (SRP) in Periodontitis, Olfactory Dysfunction and Halitosis, sponsored by Batman University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 55 Years. Per ClinicalTrials.gov, last updated 2026-10-20.

Sponsored by Batman University · Not applicable, Interventional, and Treatment

Updated Oct 20, 2026Eligibility revisedInterventions changed+4 moreGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
101
Allocation
Not applicable
Ages
18 Years to 55 Years
Sex
All
01

Study summary

This prospective cohort study investigated the relationship between oral malodor and olfactory function in adults with generalized periodontitis. A total of 101 patients were evaluated before and after routine nonsurgical periodontal therapy. Volatile sulfur compound (VSC) levels and psychophysical olfactory performance using the Sniffin' Sticks test (TDI score) were measured at baseline and one week after completion of three sessions of scaling and root planing (SRP). The study aimed to determine whether reduction of oral inflammation and halitosis is associated with improvement in olfactory performance.

Read the detailed description

Generalized periodontitis is a chronic inflammatory disease associated with increased production of volatile sulfur compounds (VSCs), contributing to halitosis. Elevated intraoral malodor may interfere with olfactory perception through masking effects and inflammatory mechanisms.

Participants diagnosed with generalized periodontitis and complaining of halitosis underwent routine nonsurgical periodontal therapy consisting of three sessions of scaling and root planing performed at one-week intervals. Olfactory function (threshold, discrimination, identification; total TDI score) and total VSC concentrations were assessed at baseline (prior to first session) and one week after completion of the third session.

The study evaluated changes in chemosensory function and halitosis parameters following periodontal therapy and analyzed correlations between baseline VSC levels and olfactory performance.

02

Conditions studied

  • Periodontitis
  • Olfactory Dysfunction
  • Halitosis
03

In context

Periodontitis

1,231 studies on the registry are indexed under Periodontitis; 295 are open to participants now.

This study's enrollment of 101 is above the median of 44 across 846 interventional studies indexed under Periodontitis.

Browse Periodontitis studies →

Lead sponsor

Batman University is the lead sponsor of 13 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 55 Years
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Inclusion Criteria:

  • Inclusion Criteria:
  • Adults aged 18-55 years
  • Diagnosis of generalized periodontitis
  • Complaint of halitosis
  • At least 15 natural teeth

Exclusion Criteria:

  • Self-reported smell loss or change within 2 weeks prior to baseline
  • Antibiotic or anti-inflammatory drug use for more than 7 days within the previous 6 weeks
  • Presence of upper respiratory tract infection
  • Unrestored advanced dental caries
  • History of COVID-19 infection
  • Pregnancy

Smoking was not an exclusion criterion.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
101 participants (actual)

Study arms

  • Experimental
    Non-Surgical Periodontal Therapy

    All enrolled patients with generalized periodontitis receive non-surgical periodontal therapy consisting of full-mouth scaling and root planing (SRP) administered over three sessions across three weeks.

    Procedure: Scaling and Root Planing (SRP)

Interventions

  • ProcedureScaling and Root Planing (SRP)

    Full-mouth non-surgical periodontal therapy consisting of scaling and root planing (SRP) performed using ultrasonic scalers and hand curettes. The therapy is administered over three sessions spanning three weeks to achieve thorough debridement of subgingival dysbiotic biofilm and calculus, alongside tongue cleaning instruction.

06

What researchers measure

Primary outcomes

  1. Change in Total TDI Score

    Change in psychophysical olfactory performance measured by the Sniffin' Sticks Test (Threshold-Discrimination-Identification composite score). The Sniffin' Sticks Test total TDI score ranges from 1 to 48, calculated as the sum of: * Odor Threshold (1-16). * Odor Discrimination (0-16). * Odor Identification (0-16). Higher scores indicate better olfactory function.

    Time frame: Baseline to 1 week after completion of third SRP session (approximately 4 weeks total)

  2. Change in Total Volatile Sulfur Compound (tVSC) Levels

    Change in total volatile sulfur compound (tVSC) concentration measured using the OralChroma portable gas chromatograph device. tVSC levels are reported in parts per billion (ppb). Higher values indicate greater halitosis severity (worse outcome).

    Time frame: Baseline to 1 week after completion of third SRP session

07

Study locations

1 site
  • Batman University
    Merkez, Batman 72040, Turkey (Türkiye)
08

References and documents

Individual participant data

Plan to share: No — Individual participant data will not be shared due to privacy considerations and institutional data protection policies.

No publications or documents are linked to this record.

09

Timeline

2 registry updates since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedDate before it movedWhere the date was before it movedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Dec 2025 to primary completion in Mar 2026, 3 months.

Of 480 non-industry interventional studies with no phase under Periodontitis, half reached primary completion within 15 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 31. This study's 3 months is below that.

Counting every sponsor, half of 494 studies reached it within 16 months; a quarter within 8 and three quarters within 31.

Since we started tracking on Sep 25, 2026, the dates moved once, on Oct 16, 2026: start Dec 2024 → Dec 2025, primary completion Mar 2025 → Mar 2026 and completion Mar 2025 → Mar 2026.

Earlier changes are on the record history on ClinicalTrials.gov ↗

How these figures are worked out, and which studies are left out of them.

Registered
Feb 13, 2026
First posted
Feb 20, 2026
StartActual
Dec 3, 2025was Dec 2024
Primary completionActual
Mar 20, 2026was Mar 2025
CompletionActual
Mar 20, 2026was Mar 2025
Last update
Oct 20, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Start date
Dec 3, 2024→Dec 3, 2025
Oct 16, 2026
Primary completion
Mar 20, 2025→Mar 20, 2026
Oct 16, 2026
Study completion
Mar 20, 2025→Mar 20, 2026
Oct 16, 2026
Eligibility
Revised
Oct 20, 2026
Interventions
Arms added: Non-Surgical Periodontal Therapy; arms removed: Generalized Periodontitis Patients With Halitosis
Oct 20, 2026
Design
Study type Observational→Interventional
Oct 20, 2026
Show all 2 updates
  1. Oct 20, 2026
    Eligibility Revised
    Interventions Arms added: Non-Surgical Periodontal Therapy; arms removed: Generalized Periodontitis Patients With Halitosis
    Design Study type Observational→Interventional
    + 2 other changes: index terms and identifiers
  2. Oct 16, 2026
    Start date Dec 3, 2024→Dec 3, 2025
    Primary completion Mar 20, 2025→Mar 20, 2026
    Study completion Mar 20, 2025→Mar 20, 2026
    + 1 other change: verification date

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07424300
Lead sponsor
Batman University
Responsible party
Mustafa Baran (Assistant Professor, Batman University) — Principal investigator
First posted
Feb 20, 2026
Start date
Dec 3, 2025
Primary completion
Mar 20, 2026
Completion
Mar 20, 2026
Last update
Oct 20, 2026

Study contacts

Mustafa Baran, Asst. Prof.
principal investigator · Batman University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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