An interventional study of Cowhage (Mucuna Pruriens) and Histamine in Itching, sponsored by Aalborg University. Completed at 1 site in Denmark. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-09.
Sponsored by Aalborg University · Not applicable, Interventional, and Other
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Among 25 studies in Pruritus by Aalborg University — 4 open to participants now, 6 under way, none of them phase 3. Pruritus · Aalborg University.
Among the 25 studies in Pruritus by Aalborg University, this one is the 9th largest by enrollment, is the only one that started in 2026, is one of 25 with no phase, and was the 25th registered.
491 studies on the registry are indexed under Pruritus; 94 are open to participants now.
Browse Pruritus studies →4 of the 25 studies in Pruritus by Aalborg University are open now, in 1 country. Recruiting first, the newest first:
Aalborg University · Sites in Denmark
Ages 18–60 · Healthy volunteers
Aalborg University · Sites in Denmark
Ages 18–60 · Healthy volunteers
Aalborg University · Sites in Denmark
Ages 18–60 · Healthy volunteers
Aalborg University · Sites in Denmark
Ages 18–80 · Healthy volunteers
By country, each count listing its studies:
Of the 54 Pruritus studies recruiting now, 22 (41%) set no upper age limit and 24 (44%) stop at 75 or younger; 15 take children under 18; 10 take healthy volunteers.
This study: 18 Years to 60 Years · all sexes · healthy volunteers too.
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25 studies; the count open now beside each. This study's row is marked.
First in 2014; this study’s year is marked. 1 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 28 is below the median of 60 across 423 interventional studies indexed under Pruritus.
Median enrollment 25 across the 25 interventional studies. Of the 16 that completed or were terminated, 0 (0%) have results posted.
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Aalborg University is the lead sponsor of 183 studies on the registry; 32 are open to participants now.
2 of the studies in Pruritus by Aalborg University that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06997926Aalborg UniversityIdentification of the Mechanism of Non-histaminergic Itch Inducing Epigenetic Changes | 2026-12-31 |
| NCT07122973Aalborg UniversityTopographical Distribution of Itch and Pain Receptors | 2026-12-31 |
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Among the 25 studies in Pruritus by Aalborg University, from their registry updates:
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This project aims to create a reliable, long-lasting itch model by synergistically combining thermal pre-conditioning with the application of histamine or cowhage.
Two areas (4x4 cm, one on each forearm), will be selected. Initially, superficial blood perfusion will be measured in each area, followed by pruritogens application. During the 10 minutes of the application of the pruritogens, itch will be continuously monitored using a VAS scale. After the pruritogens application, assessment of the superficial blood perfusion (SBP), mechanical sensitivity, and thermal sensitivity will be conducted. The session will be identical to the first session, but pre-heat conditioning will be applied prior to pruritogens application.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Heath will be applied prior pruritogens application
Other: Cowhage (Mucuna Pruriens) · Other: Histamine · Other: Heat
The spicules will be manually inserted. Approximately 30-35 spicules are gently rubbed into a 1 cm diameter skin area on the forearm/face
To deliver histamine, standard allergy skin prick test (SPT) lancets are applied
45 °C x 5 min
Measuring pain by computerized Visual Analog Scale Scoring
We will ask the subjects to rate the sensation of pain on a 100
Time frame: Day 1
Measuring Itch by computerized Visual Analog Scale Scoring
We will ask the subjects to rate the sensation of itch on a 100
Time frame: Day 1
Measuring pain by computerized Visual Analog Scale Scoring
We will ask the subjects to rate the sensation of pain on a 100
Time frame: Day 2
Measuring Itch by computerized Visual Analog Scale Scoring
We will ask the subjects to rate the sensation of itch on a 100
Time frame: Day 2
Superficial blood perfusion
Superficial blood perfusion (SBP) is measured by a Speckle contrast imager
Time frame: Day 1
Superficial blood perfusion
Superficial blood perfusion (SBP) is measured by a Speckle contrast imager
Time frame: Day 2
Alloknesis
Measured using a standardized sensory brush exerting a force of 200 to 400 mN.
Time frame: Day 1
Alloknesis
Measured using a standardized sensory brush exerting a force of 200 to 400 mN.
Time frame: Day 2
Mechanically evoked itch (MEI)
MEI is measured by using mildly pruritic, non-painful von Frey nylon filaments of a predetermined intensity (generally 5-30 miliNewton of force).
Time frame: Day 1
Mechanically evoked itch (MEI)
MEI is measured by using mildly pruritic, non-painful von Frey nylon filaments of a predetermined intensity (generally 5-30 miliNewton of force).
Time frame: Day 2
Mechanical Pain Thresholds (MPT)
This test is conducted using a pinprick set. The set consists of 7 needles each with a diameter of 0.6 mm and different force applications: 8, 16, 32, 64, 128, 256, and 512 mN.
Time frame: Day 1
Mechanical Pain Thresholds (MPT)
This test is conducted using a pinprick set. The set consists of 7 needles each with a diameter of 0.6 mm and different force applications: 8, 16, 32, 64, 128, 256, and 512 mN.
Time frame: Day 2
Mechanical Pain Sensitivity (MPS)
This test is conducted with the same pinprick set used to test the MPT.
Time frame: Day 1
Mechanical Pain Sensitivity (MPS)
This test is conducted with the same pinprick set used to test the MPT.
Time frame: Day 2
Cold Detection Thresholds (CDT)
The tests of thermal sensation will all be conducted using a PATHWAY ATS (Medoc Ltd, Israel) thermal sensory testing device
Time frame: Day 1
Cold Detection Thresholds (CDT)
The tests of thermal sensation will all be conducted using a PATHWAY ATS (Medoc Ltd, Israel) thermal sensory testing device
Time frame: Day 2
Warm Detection Thresholds (WDT)
The tests of thermal sensation will all be conducted using a PATHWAY ATS (Medoc Ltd, Israel) thermal sensory testing device
Time frame: Day 1
Warm Detection Thresholds (WDT)
The tests of thermal sensation will all be conducted using a PATHWAY ATS (Medoc Ltd, Israel) thermal sensory testing device
Time frame: Day 2
Cold Pain Thresholds (CPT)
The tests of thermal sensation will all be conducted using a PATHWAY ATS (Medoc Ltd, Israel) thermal sensory testing device
Time frame: Day 1
Cold Pain Thresholds (CPT)
The tests of thermal sensation will all be conducted using a PATHWAY ATS (Medoc Ltd, Israel) thermal sensory testing device
Time frame: Day 2
Heat Pain Thresholds (HPT)
The tests of thermal sensation will all be conducted using a PATHWAY ATS (Medoc Ltd, Israel) thermal sensory testing device
Time frame: Day 1
Heat Pain Thresholds (HPT)
The tests of thermal sensation will all be conducted using a PATHWAY ATS (Medoc Ltd, Israel) thermal sensory testing device
Time frame: Day 2
Pain to Supra-threshold Heat Stimuli (STHS)
The tests of thermal sensation will all be conducted using a PATHWAY ATS (Medoc Ltd, Israel) thermal sensory testing device
Time frame: Day 1
Pain to Supra-threshold Heat Stimuli (STHS)
The tests of thermal sensation will all be conducted using a PATHWAY ATS (Medoc Ltd, Israel) thermal sensory testing device
Time frame: Day 2
Ran from Feb 2026 to primary completion in Sep 2026, 7 months.
Of 85 non-industry interventional studies with no phase under Pruritus, half reached primary completion within 7 months of starting (the median), counting those still running; a quarter within 4 and three quarters within 14. This study's 7 months is close to that.
Counting every sponsor, half of 101 studies reached it within 7 months; a quarter within 3 and three quarters within 13.
Since we started tracking on Sep 25, 2026, the dates moved once, on Nov 9, 2026: primary completion Dec 2028 → Sep 2026 and completion Dec 2029 → Sep 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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