CClinicalTrials.gg
CompletedNCT07384858Updated Aug 18, 2026

Effects of Attentional Focus Strategies During Isokinetic Quadriceps Training on Strength and Functional Performance in Individuals With Patellofemoral Pain Syndrome.

An interventional study of Internal focus group and External focus in Patellofemoral Pain, PFP, sponsored by Istanbul University - Cerrahpasa. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-08-18.

Sponsored by Istanbul University - Cerrahpasa · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
36
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
All
01

Study summary

Patellofemoral pain syndrome (PFPS) is a multifactorial musculoskeletal condition that is common particularly among young and physically active individuals, negatively affecting activities of daily living and physical performance. Although exercise therapy is considered the gold standard in the management of PFPS, there is limited evidence regarding the effectiveness of motor learning strategies applied during exercise. This study aims to shed light on how motor learning approaches can be optimized in clinical rehabilitation by comparing the effects of internal and external focus strategies used during exercise on muscle activation, functional performance, and pain.

This research will make a methodological contribution to the literature through the objective evaluation of muscle mechanical properties using isokinetic assessment and the MyotonPRO device. The findings are expected to clarify the effects of attentional focus strategies on therapeutic outcomes in PFPS rehabilitation and have the potential to provide an evidence-based guide for physiotherapy practice. In this way, the study may contribute to the development of new approaches aimed at improving both clinical effectiveness and patient adherence.

02

Conditions studied

  • Patellofemoral Pain, PFP
03

In context

Patellofemoral Pain Syndrome

295 studies on the registry are indexed under Patellofemoral Pain Syndrome; 75 are open to participants now.

This study's enrollment of 36 is below the median of 45 across 242 interventional studies indexed under Patellofemoral Pain Syndrome.

Browse Patellofemoral Pain Syndrome studies →

Lead sponsor

Istanbul University - Cerrahpasa is the lead sponsor of 680 studies on the registry; 208 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Aged between 18 and 45 years.
  • Diagnosed with patellofemoral pain syndrome (PFPS).
  • Anterior or retropatellar knee pain persisting for at least four weeks with a VAS score > 3.
  • Pain exacerbated by at least two functional activities (e.g., squatting, stair climbing, prolonged sitting).
  • Willing to regularly participate in the 6-week program throughout the study period.

Exclusion criteria

Exclusion Criteria:

  • History of patellar subluxation or dislocation.
  • Anterior or posterior cruciate ligament insufficiency.
  • Lower extremity fractures.
  • Neurological or systemic musculoskeletal disorders.
  • Rheumatoid arthritis or other inflammatory joint diseases.
  • History of knee surgery, meniscal injury, or any other underlying musculoskeletal condition that would prevent the participant from performing the exercises.
  • Pregnancy or postpartum period.
  • Participation in a similar exercise program within the last 3 months.
  • Radiographic evidence of osteoarthritis classified as Kellgren-Lawrence grade 2 or higher.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
36 participants (actual)

Study arms

  • Experimental
    Internal focus

    Other: Internal focus group

  • Experimental
    External focus

    Other: External focus

Interventions

  • OtherInternal focus group

    Internal focus refers to directing attention to one's own body movements or muscle activity while performing a task (e.g., focusing on contracting a specific muscle). During isokinetic strength exercises, this group is instructed with commands such as: "Tighten your quadriceps" and "Straighten your knee."

  • OtherExternal focus

    External focus refers to directing attention to the effect of a movement on the environment or an external object, rather than on the body itself. During isokinetic exercise, this group is given the instruction: "Increase and maintain the performance indicator on the screen."

06

What researchers measure

Primary outcomes

  1. Kujala Patellofemoral Pain Score

    Kujala Patellofemoral Pain Score is a valid and reliable self-reported outcome measure specific to patellofemoral pain syndrome that assesses knee function and pain-related limitations during daily activities. The total score ranges from 0 to 100, with higher scores indicating better knee function and fewer symptoms.

    Time frame: baseline

  2. Kujala Patellofemoral Pain Score

    Kujala Patellofemoral Pain Score is a valid and reliable self-reported outcome measure specific to patellofemoral pain syndrome that assesses knee function and pain-related limitations during daily activities. The total score ranges from 0 to 100, with higher scores indicating better knee function and fewer symptoms.

    Time frame: Week 3 of the Treatment

  3. Kujala Patellofemoral Pain Score

    Kujala Patellofemoral Pain Score is a valid and reliable self-reported outcome measure specific to patellofemoral pain syndrome that assesses knee function and pain-related limitations during daily activities. The total score ranges from 0 to 100, with higher scores indicating better knee function and fewer symptoms.

    Time frame: Week 6 of the Treatment

Secondary outcomes

  1. Visual Analog Scale

    Visual Analog Scale (VAS) is a simple and reliable tool used to assess the intensity of knee pain. Participants rate their pain on a 0 to 10 cm scale, with higher scores indicating greater pain severity. It was used to evaluate changes in pain before and after exercise.

    Time frame: baseline

  2. Visual Analog Scale

    Visual Analog Scale (VAS) is a simple and reliable tool used to assess the intensity of knee pain. Participants rate their pain on a 0 to 10 cm scale, with higher scores indicating greater pain severity. It was used to evaluate changes in pain before and after exercise.

    Time frame: Week 3 of the Treatment

  3. Visual Analog Scale

    Visual Analog Scale (VAS) is a simple and reliable tool used to assess the intensity of knee pain. Participants rate their pain on a 0 to 10 cm scale, with higher scores indicating greater pain severity. It was used to evaluate changes in pain before and after exercise.

    Time frame: Week 6 of the Treatment

  4. Isokinetic Muscle Strength Assessment (Isoforce)

    Muscle performance will be objectively evaluated by measuring concentric strength values of the quadriceps muscle.

    Time frame: baseline

  5. Isokinetic Muscle Strength Assessment (Isoforce)

    Muscle performance will be objectively evaluated by measuring concentric strength values of the quadriceps muscle.

    Time frame: Week 3 of the Treatment

  6. Isokinetic Muscle Strength Assessment (Isoforce)

    Muscle performance will be objectively evaluated by measuring concentric strength values of the quadriceps muscle.

    Time frame: Week 6 of the Treatment

  7. Muscle Tone

    Muscle tone was assessed using the MyotonPRO device, expressed in Hertz (Hz), with higher values indicating increased resting muscle tone.

    Time frame: baseline

  8. Muscle Tone

    Muscle tone was assessed using the MyotonPRO device, expressed in Hertz (Hz), with higher values indicating increased resting muscle tone.

    Time frame: Week 3 of the Treatment

  9. Muscle Tone

    Muscle tone was assessed using the MyotonPRO device, expressed in Hertz (Hz), with higher values indicating increased resting muscle tone.

    Time frame: Week 6 of the Treatment

  10. Muscle Stiffness

    Muscle stiffness was measured using the MyotonPRO device, expressed in Newton per meter (N/m), with higher values indicating greater muscle stiffness.

    Time frame: baseline

  11. Muscle Stiffness

    Muscle stiffness was measured using the MyotonPRO device, expressed in Newton per meter (N/m), with higher values indicating greater muscle stiffness.

    Time frame: Week 3 of the Treatment

  12. Muscle Stiffness

    Muscle stiffness was measured using the MyotonPRO device, expressed in Newton per meter (N/m), with higher values indicating greater muscle stiffness.

    Time frame: Week 6 of the Treatment

  13. Muscle Elasticity

    Muscle elasticity was evaluated using the MyotonPRO device, expressed as logarithmic decrement, with lower values indicating better elastic properties.

    Time frame: baseline

  14. Muscle Elasticity

    Muscle elasticity was evaluated using the MyotonPRO device, expressed as logarithmic decrement, with lower values indicating better elastic properties.

    Time frame: Week 3 of the Treatment

  15. Muscle Elasticity

    Muscle elasticity was evaluated using the MyotonPRO device, expressed as logarithmic decrement, with lower values indicating better elastic properties.

    Time frame: Week 6 of the Treatment

  16. Step-Down Test

    Step-Down Test was used to assess lower-extremity control and functional performance. Participants were instructed to perform as many step-down repetitions as possible within 30 seconds. Performance was recorded as the number of completed repetitions, with higher scores indicating better functional capacity and dynamic knee stability.

    Time frame: baseline

  17. Step-Down Test

    Step-Down Test was used to assess lower-extremity control and functional performance. Participants were instructed to perform as many step-down repetitions as possible within 30 seconds. Performance was recorded as the number of completed repetitions, with higher scores indicating better functional capacity and dynamic knee stability.

    Time frame: Week 3 of the Treatment

  18. Step-Down Test

    Step-Down Test was used to assess lower-extremity control and functional performance. Participants were instructed to perform as many step-down repetitions as possible within 30 seconds. Performance was recorded as the number of completed repetitions, with higher scores indicating better functional capacity and dynamic knee stability.

    Time frame: Week 6 of the Treatment

  19. Single-Leg Hop Test

    Single-Leg Hop Test was used to assess functional performance and dynamic knee stability. Participants were instructed to perform a maximal forward hop on the affected limb. The hop distance was measured in centimeters (cm), with greater distances indicating better functional performance.

    Time frame: baseline

  20. Single-Leg Hop Test

    Single-Leg Hop Test was used to assess functional performance and dynamic knee stability. Participants were instructed to perform a maximal forward hop on the affected limb. The hop distance was measured in centimeters (cm), with greater distances indicating better functional performance.

    Time frame: Week 3 of the Treatment

  21. Single-Leg Hop Test

    Single-Leg Hop Test was used to assess functional performance and dynamic knee stability. Participants were instructed to perform a maximal forward hop on the affected limb. The hop distance was measured in centimeters (cm), with greater distances indicating better functional performance.

    Time frame: Week 6 of the Treatment

07

Study locations

1 site
  • Istanbul University-Cerrahpasa
    Istanbul, Turkey (Türkiye)
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 18, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07384858
Lead sponsor
Istanbul University - Cerrahpasa
Responsible party
Seda Ateş (physiotherapist, Istanbul University - Cerrahpasa) — Principal investigator
First posted
Feb 3, 2026
Start date
Feb 2, 2026
Primary completion
Jul 30, 2026
Completion
Jul 30, 2026
Last update
Aug 18, 2026

Study contacts

SEZEN KARABÖRKLÜ ARGUT, Assistant Professor
study director · Istanbul University-Cerrahpaşa, Faculty of Health Science

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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