An observational study in Pemphigus Vulgaris (PV) and Periodontal Diseases, sponsored by Saglik Bilimleri Universitesi. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-07.
Sponsored by Saglik Bilimleri Universitesi · Observational
The aim of this study is to evaluate the relationship between the severity of Pemphigus Vulgaris (a chronic autoimmune skin disease) and periodontal (gum) health, and to compare the findings with those of a systemically healthy control group. Researchers will assess disease activity using the Oral Disease Severity Score (ODSS) for oral lesions and measure serum Desmoglein 1 and 3 levels through blood tests. These findings will be compared with clinical periodontal parameters, such as probing pocket depth and clinical attachment levels, in both groups. The study intends to determine how the clinical and biochemical severity of Pemphigus Vulgaris impacts periodontal tissues and overall oral health, as well as identify potential differences in periodontal status between patients with Pemphigus Vulgaris and systemically healthy individuals.
76 studies on the registry are indexed under Pemphigus; 18 are open to participants now.
This study's enrollment of 25 is below the median of 60 across 21 observational studies indexed under Pemphigus.
Browse Pemphigus studies →Saglik Bilimleri Universitesi is the lead sponsor of 453 studies on the registry; 140 are open to participants now.
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The criteria were revised on the registry on Oct 7, 2026. See what changed
The study population consists of adult patients diagnosed with Pemphigus Vulgaris who are receiving treatment or follow-up at the dermatology clinic.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A comprehensive oral examination including ODSS scoring and periodontal measurements (PPD, CAL, PI, GI). Additionally, serum Desmoglein 1 and 3 levels will be retrieved from the patients' medical records for biochemical correlation.
Other: Clinical Periodontal and Oral Evaluation
Systemically healthy individuals without a diagnosis of Pemphigus Vulgaris will be included in the control group. Participants will undergo a clinical periodontal examination, including assessment of probing pocket depth, clinical attachment level, and other relevant periodontal parameters. The periodontal status of the control group will be compared with that of patients with Pemphigus Vulgaris to evaluate differences in periodontal health. No therapeutic intervention will be administered as part of the study.
Other: Clinical Periodontal and Oral Evaluation
"Participants will undergo a comprehensive oral examination. The severity of oral mucosal involvement will be recorded using the Oral Disease Severity Score (ODSS). Clinical periodontal parameters, including Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL), will be measured at six sites per tooth using a periodontal probe. Additionally, current serum Desmoglein 1 and 3 levels will be retrieved from the patients' medical records for clinical correlation."
Oral Disease Severity Score (ODSS)
A clinical scoring system used to assess the severity of oral mucosal involvement in patients with Pemphigus Vulgaris. It evaluates the site and extent of lesions in the oral cavity.
Time frame: Baseline
Serum Desmoglein 1 and 3 Levels
Anti-desmoglein 1 and anti-desmoglein 3 autoantibody titers as recorded in the patients' medical laboratory results. Values are measured in Relative Units per milliliter (RU/mL).
Time frame: Baseline
Clinical Attachment Level (CAL)
Measurement of the distance from the cemento-enamel junction to the base of the periodontal pocket in millimeters. Higher values indicate greater attachment loss.
Time frame: Baseline
Probing Pocket Depth (PPD)
Measurement of the distance from the gingival margin to the base of the periodontal pocket in millimeters using a periodontal probe.
Time frame: Baseline
Plaque Index (PI)
An index used to assess the thickness of plaque at the gingival margin. It evaluates oral hygiene status on a scale from 0 to 3 for each tooth surface, measured according to the criteria of Silness and Löe.
Time frame: Baseline
Gingival Index (GI)
A clinical index used to assess the severity of gingival inflammation and bleeding tendency. It evaluates the color, consistency, and bleeding of the gums on a scale from 0 to 3, measured according to the criteria of Silness and Löe.
Time frame: Baseline
Plan to share: No — To protect participant privacy and maintain confidentiality, there are no plans to share individual participant data.
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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