An interventional study of Clear Aligners with Composite Attachments in Malocclusion, Crowded Teeth and Attachment, sponsored by Bezmialem Vakif University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 12 Years and older. Per ClinicalTrials.gov, last updated 2026-01-20.
Sponsored by Bezmialem Vakif University · Not applicable, Interventional, and Treatment
Among 30 studies in Malocclusion with a site in Turkey — 7 open to participants now, 8 under way, none of them phase 3. Malocclusion · Turkey.
Among the 30 studies in Malocclusion with a site in Turkey, this one is the 17th largest by enrollment of the 17 interventional ones, is the only one that started in 2022, is one of 17 with no phase, and was the 23rd registered.
323 studies on the registry are indexed under Malocclusion; 85 are open to participants now.
This study's enrollment of 4 is below the median of 37 across 242 interventional studies indexed under Malocclusion.
Browse Malocclusion studies →7 of the 30 studies in Malocclusion with a site in Turkey are open now, in 1 country. Each count lists the studies.
Of the 42 Malocclusion studies recruiting now, 8 (19%) set no upper age limit and 34 (81%) stop at 75 or younger; 33 take children under 18; 18 take healthy volunteers.
This study: 12 Years and older · all sexes · no healthy volunteers.
The full table on the hub →30 studies; the count open now beside each. This study's row is marked.
First in 2017; this study’s year is marked. 1 started in 2022.
Median enrollment 35 across the 17 interventional studies, 70 across the 13 observational. Of the 22 that completed or were terminated, 0 (0%) have results posted.
None of the 30 has an industry lead sponsor. The 10 most frequent:
Bezmialem Vakif University is the lead sponsor of 354 studies on the registry; 59 are open to participants now.
Bezmialem Vakif University has 2 studies filed under Malocclusion — fewer than ten, so there is no comparison to draw.
2 of the studies in Malocclusion with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07802249Ravan MammadovPeriodontal Health in Adults Treated With Fixed Orthodontic Appliances or Clear Aligners | 2026-12-25 |
| NCT07702448Kırıkkale UniversityChanges in Depression and Esthetic Perception After Orthognathic Surgery | 2027-06-20 |
Among the 30 studies in Malocclusion with a site in Turkey, from their registry updates:
This prospective clinical study evaluated the incidence of composite attachment loss in patients undergoing clear aligner treatment and identified patient-, tooth-, and treatment-related factors associated with attachment debonding. Twenty-one patients were followed for six months, and attachment failures were recorded at routine visits. Outcomes were compared according to attachment type (conventional vs. optimized), attachment size, tooth type, dental arch, and patient-related factors.
Composite attachments are integral to clear aligner therapy for improving force delivery, retention, and control of complex tooth movements. Despite their biomechanical importance, attachment loss remains a common clinical challenge and may compromise treatment efficiency and predictability. In this prospective study, attachments were bonded following the manufacturer's protocol using a high-viscosity composite. Patients were followed for six months, and attachment failures were documented with respect to type, size, tooth position, and patient-related behaviors. The primary objective was to determine the incidence of attachment loss and to identify factors associated with debonding, thereby contributing to clinical strategies that may reduce attachment failure and enhance treatment outcomes.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Permanent dentition. Mild to moderate crowding. No history of previous orthodontic treatment with fixed appliances or clear aligners
Exclusion Criteria:
Poor oral health. Bruxism. Crown restorations. Dental fluorosis. Enamel hypoplasia or other structural abnormalities affecting attachment bonding
Participants received clear aligner therapy (Invisalign®) with composite attachments bonded according to the manufacturer's protocol. Both conventional and optimized attachment types were used as part of the planned orthodontic treatment, and attachment loss was prospectively evaluated over a 6-month follow-up period.
Device: Clear Aligners with Composite Attachments
Participants received clear aligner therapy (Invisalign®, Align Technology, San Jose, CA, USA). Composite attachments were bonded according to the manufacturer's protocol using a high-viscosity composite. Both conventional and optimized attachment types were used as part of the planned orthodontic treatment, and attachment loss was prospectively evaluated during a 6-month follow-up period.
Attachment Loss Rate
Proportion of composite attachments exhibiting complete detachment or partial debonding (irregular residual composite) during routine follow-up visits. Attachment loss was assessed by direct intraoral examination and tactile verification using a dental explorer.
Time frame: 6 months
Plan to share: No
No publications or documents are linked to this record.
Ran from Jan 2022 to primary completion in Jun 2022, 5 months.
Of 153 non-industry interventional studies with no phase under Malocclusion, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 30. This study's 5 months is below that.
Counting every sponsor, half of 163 studies reached it within 19 months; a quarter within 10 and three quarters within 32.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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