An interventional study of Transcranial Magnetic Stimulation and general behavioral therapy in Tic Disorders, sponsored by Shanghai Children's Medical Center. Recruiting at 1 site in China. Open to participants aged 5 Months to 18 Years. Per ClinicalTrials.gov, last updated 2026-01-20.
Sponsored by Shanghai Children's Medical Center · Not applicable, Interventional, and Treatment
This study aims to establish a novel personalized closed-loop NiBS/TMS therapeutic strategy and clinical protocol for children with Tic Disorders (TDs) through a series of scientific investigations. Additionally, it seeks to elucidate the underlying neural circuit mechanisms, enhance the therapeutic efficacy of TMS in pediatric TDs, and achieve precision neuromodulation for children with TDs.
102 studies on the registry are indexed under Tic Disorders; 26 are open to participants now.
This study's planned enrollment of 60 is above the median of 50 across 83 interventional studies indexed under Tic Disorders.
Browse Tic Disorders studies →Shanghai Children's Medical Center is the lead sponsor of 38 studies on the registry; 14 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
1: Children and adolescents aged 5 to 18 years
2: Meets diagnostic criteria for Tic Disorders (TDs) with normal EEG findings
3: No prior treatment received for TDs
4: Full-scale intelligence quotient (FIQ) ≥70 on the Wechsler Intelligence Scale for Children-Revised (WISC-R)
Exclusion Criteria:
1: WISC-R Full-Scale Intelligence Quotient (FIQ) \<70
2: Presence of metal implants in the body ，Non-right-handedness
3: Head movement (HM) >2mm during fMRI scanning, including both translational movement (TM) and rotational movement (RM)
4: Any other neurological or psychiatric conditions, including but not limited to autism spectrum disorder (ASD), epilepsy, obsessive-compulsive disorder (OCD), etc
5: Previous head trauma ，Neurological diseases ，Major systemic illnesses
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The child will use a transcranial magnetic stimulator model ZL-N-010 to stimulate preselected targets located in the prefrontal lobe, bilateral temporal lobes, and parietal lobe. The child may rest as needed during the treatment process. Each TMS session lasts approximately 30 minutes. A total of 10 sessions will be administered. They will also use general behavioral therapy.
Device: Transcranial Magnetic Stimulation · Behavioral: general behavioral therapy
The child will receive sham stimulation and general behavioral therapy.
Behavioral: general behavioral therapy
Transcranial magnetic stimulation (TMS) will be administered to the child using a ZL-N-010 model device, targeting predefined sites in the prefrontal, bilateral temporal, and parietal lobes.
Behavioral interventions include avoiding screen time, parental avoidance of scolding or corporal punishment, and steering clear of activities or emotional stimuli that may exacerbate symptoms.
Tic Severity
The severity of the child's clinical tic symptoms assessed via the Yale Global Tic Severity Scale.
Time frame: 10 weeks
Changes in brain region activation intensity and resting-state connectivity before and after treatment.
Based on fMRI imaging, changes in brain region activation intensity (BOLD signals) and resting-state functional connectivity (FC) before and after treatment were compared.
Time frame: 10 weeks
Plan to share: No
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Shanghai Children's Medical Center